A5102992576- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- S100 Proteins and Annexins
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Immune cells in cancer
- Tracheal and airway disorders
- Oral Health Pathology and Treatment
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Radiomics and Machine Learning in Medical Imaging
- DNA Repair Mechanisms
- Neuroblastoma Research and Treatments
- Voice and Speech Disorders
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- Chinese history and philosophy
- Foreign Body Medical Cases
- Chemokine receptors and signaling
Central South University
2011-2025
Xiangya Hospital Central South University
2011-2025
Hunan Provincial Center for Disease Control and Prevention
2021-2025
Guangxi University
2025
Fujian University of Technology
2024
Hubei Academy of Agricultural Sciences
2020-2024
Ministry of Agriculture and Rural Affairs
2024
China United Network Communications Group (China)
2024
Xiamen University of Technology
2023
Hunan Provincial Science and Technology Department
2023
Abstract Background and Objective Previous studies suggest interaction between periodontitis thyroid function, while the causality has not yet been established. We applied Mendelian randomization (MR) method to assess bidirectional causal association thyroid‐related traits, including free thyroxine (FT4), stimulating hormone (TSH), hypothyroidism, hyperthyroidism autoimmune disease (AITD). Methods Genetic instruments were extracted from large‐scale genome‐wide on normal‐range FT4 ( N = 49...
Abstract Metastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of head neck (SCCHN). However, mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine key microRNA their functional involved metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used quantify level miR‐30e‐5p its clinical significance further analyzed. A series vitro vivo experiments were applied...
Quantum key distribution (QKD) has attracted much attention on secure communications across global networks. QKD over satellite networks can overcome the limitations of terrestrial optical networks, such as large attenuation long distance fiber channel and difficulty intercontinental domain communications. Different (around world) intercommunicate through quantum satellites, leading to a network in near future. This raises new resource allocation management problem involving multiple layers...
Abstract The canonical Wnt/β‐catenin signalling pathway and autophagy play critical roles in cancer progression. However, the role of Wnt‐mediated radioresistance remains unclear. In this study, we found that irradiation activated autophagic pathways squamous cell carcinoma head neck (SCCHN). Wnt3a is a classical ligand pathway, induced decreased sensitivity SCCHN to both vitro vivo. Further mechanistic analysis revealed promoted via protective autophagy. Finally, expression protein was...
Invasion and metastasis represent the primary causes of therapeutic failure in patients diagnosed with squamous cell carcinoma head neck (SCCHN). Therefore, disease prediction inhibition invasion are critical for enhancing survival SCCHN. Our previous study revealed that increased expression miR-93-5p is associated poor prognosis SCCHN; however, mechanism underlying oncogenic functions SCCHN migration remains unclear. Using qPCR analyses, transwell assays, scratch tests, we demonstrated...
Previous studies have revealed that Epstein-Barr virus (EBV) was closely associated with nasopharyngeal carcinoma (NPC). This study aimed to characterize the global pathways affected in EBV-associated NPC. Combined microdissection, gene expression profiles 22 NPCs and 10 non-tumor epithelial (NPE) tissue samples were analyzed. All NPC specimens served microarray analysis positive for EBV, as judged by identification of EBV nuclear antigen 1 (EBNA1). Through set enrichment (GSEA), we found...
Epidermal growth factor receptor (EGFR) has been reported to downregulate E-cadherin (E-cad); however, whether the downregulation of E-cad any effect on EGFR expression not elucidated. Our previous studies have found an inverse correlation between and in tissue specimens squamous cell carcinoma head neck (SCCHN). To understand biological mechanisms underlying this clinical observation, we knocked down utilizing siRNA four SCCHN lines.It was observed that upregulated compared with control...
To build an automatic pathological diagnosis model to assess the lymph node metastasis status of head and neck squamous cell carcinoma (HNSCC) based on deep learning algorithms.A retrospective study.A diagnostic integrating two-step networks was trained analyze in 85 images HNSCC nodes. The tested a test set 21 with 29 without metastasis. All were scanned from sections stained hematoxylin-eosin (HE).In set, overall accuracy, sensitivity, specificity reached 86%, 100%, 75.9%, respectively.Our...
The study aims to establish a pre-academic diagnostic tool based on deep learning and conventional radiomics features guide the clinical decision-making of parapharyngeal space (PPS) tumors. This retrospective included 217 patients with PPS tumors, from two medical centers in China March 1, 2011, October 2023. cohort was divided into training set (n = 145) test 72). A (DL) model (Rad) neck MRI were constructed distinguish malignant tumors (MTs) benign (BTs) (DLR) which integrates further...
Therapeutic strategies aimed at harnessing anti-tumor immunity are being intensively investigated as they show promising results in cancer treatment. The PD-1/ PD-L1 pathway is an essential target for restoring functional immune response. BRD7 a candidate tumor suppressor gene and nuclear transcription factor of nasopharyngeal carcinoma (NPC) which was cloned our laboratory. In this paper, we reported that the strongly associated with good prognosis NPC patients negatively regulated...
Characterizing the variety of cell types in tumor microenvironment (TME) and their organization into cellular communities is vital for elucidating biological diversity cancer informing therapeutic strategies. Here, we employed a machine learning-based algorithm framework, EcoTyper, to analyze single-cell transcriptomes from 139 patients with head neck squamous carcinoma (HNSC)and gene expression profiles 983 additional HNSC patients, aiming delineate fundamental states ecosystems integral...
Small and micro enterprises (SMEs) encounter big blows while operating in VUCA (Volatility, Uncertainty, Complexity, Ambiguity) environment as a result of their resource constrains external dependencies. This study build conceptual model that links organized performance to the elements environmental factors, internal resources, resilience capabilities, contribution building SMEs. From systematically reviewing literature on organisational theories, specifies pathways how SMEs adapt thrive...
In addressing the challenges posed by sluggish convergence rate, suboptimal stability, and susceptibility to local optimization in function problems, a multi-strategy-based enhanced slime mold algorithm (MSSMA) has been proposed. This integrates chaotic mapping inverse learning enhance speed of initial population. Additionally, novel balancing factor, B, introduced ensure more equitable distribution algorithm’s exploration exploitation. The Lévy flight strategy elite tangent search have...
Human SPLUNC 1 can suppress nasopharyngeal carcinoma ( NPC ) tumor formation; however, the correlation between 1expression and patient prognosis has not been reported. In present study, we used a large‐scale sample of 1015 tissue cores to detect expression its association with prognosis. was reduced in samples compared nontumor epithelium tissues. Positive predicted better (disease‐free survival, P = 0.034; overall 0.048). Cox's proportional hazards model revealed that could be significant...
Nasopharyngeal carcinoma (NPC) is a head and neck malignant tumor rare throughout most of the world but common in Southeast Asia, especially Southern China. Flotillin-2 (Flot-2) not only an important component cellular membrane, also involves various processes such as membrane trafficking, T cell B activation, regulation several signaling pathways associated with growth transformation, keeping structure junction epidermal cells formation filopodia. Although molecular effects Flot-2 have been...
Atractylodes macrocephala (A. macrocephala), a famous medicinal herb in China, is widely cultivated and consumed China with various beneficial effects. Numerous studies have shown that selenium (Se) plays an important role promoting plant growth, although Se has not been considered essential element for higher plants. The objectives of this research were to determine the effects foliar application (0, 2.5, 5.0, 10.0 20.0 mg m-2 sodium selenite, sprayed monthly from May August) on growth...
To compare the efficacy and safety of remimazolam with those propofol for drug-induced sleep endoscopy (DISE) in patients obstructive apnea-hypopnea syndrome (OSAHS).A prospective, single-center, randomized clinical trial.Xiangya Hospital Central South University.Patients OSAHS receiving DISE were randomly assigned to either or group. The primary outcome was incidence hypoxemia (pulse oxygen saturation [SpO2 ] < 90%) during DISE. secondary outcomes severe (SpO2 80%), minimal value SpO2 ,...
Nanoparticle quantum dots (QDs) are ideal materials for multiplexed biomarker detection, localization, and quantification. Both direct indirect methods available QD-based immunohistofluorescence (QD-IHF) staining; the method, however, has been considered laborious costly. In this study, we optimized compared QD-IHF single staining procedure using QD-secondary antibody conjugates QD-streptavidin conjugates. Problems associated with sequential multiplex were identified quantitatively. A method...
Myeloid cells are a major heterogeneous cell population in the tumor immune microenvironment (TIME). Imbalance of myeloid response remains obstacle to favorable prognosis and successful therapy. Therefore, we aimed construct risk model evaluate contexture, which may facilitate prediction infiltration patients with head neck squamous carcinoma (HNSCC). In our study, six signature genes (including CCL13, CCR7, CD276, IL1B, LYVE1 VEGFC) analyzed from 52 differentially expressed were finally...
In order to study the bending properties of tropical tree species rich in organic extracts, effects temperature and time on performance hydrothermal treatment were investigated. The power under microwave heating conditions It is found that chemical composition does not undergo obvious degradation at 80°C–100°C, gradually becomes better with increase time; when exceeds 4 h, varies time. growth than difference, reaching maximum h. When water 140°C, negatively correlated same, property as...
Migration and invasion are the initial step in metastatic process, while metastasis is responsible for poor prognosis of head neck squamous cell carcinoma (HNSCC). Since miRNA has been found as an important regulator gene expression at post-transcriptional level various diseases including carcinoma, exploring role cancer will facilitate target therapy advanced HNSCC. MiR-328-3p reported to be onco-miRNA or a tumor suppressor several cancers. However, miR-328-3p HNSCC migration remains...
To investigate the role of pre-treatment magnetic resonance imaging (MRI) radiomics for preoperative prediction lymph node (LN) metastasis in patients with hypopharyngeal squamous cell carcinoma (HPSCC).A total 155 HPSCC were eligibly enrolled from single institution. Radiomics features extracted contrast-enhanced axial T-1 weighted (CE-T1WI) sequence. The most relevant LN selected by least absolute shrinkage and selection operator (LASSO) method. Univariate multivariate logistic regression...