A5102850236- Molecular Junctions and Nanostructures
- Spectroscopy and Quantum Chemical Studies
- Synthetic Organic Chemistry Methods
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- Surface Chemistry and Catalysis
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Electrocatalysts for Energy Conversion
- Quantum Dots Synthesis And Properties
- Organic Electronics and Photovoltaics
- Epigenetics and DNA Methylation
- Robotics and Sensor-Based Localization
- Nanowire Synthesis and Applications
- Quantum-Dot Cellular Automata
- Quantum and electron transport phenomena
- Advanced Image and Video Retrieval Techniques
- Ferroptosis and cancer prognosis
- 3D Shape Modeling and Analysis
- Cancer-related molecular mechanisms research
- Methane Hydrates and Related Phenomena
- Genetics and Neurodevelopmental Disorders
- Effects of Radiation Exposure
- Genetic Syndromes and Imprinting
- Image Retrieval and Classification Techniques
Beijing National Laboratory for Molecular Sciences
2021-2025
Peking University
2013-2025
China University of Geosciences (Beijing)
2025
Third Xiangya Hospital
2023-2025
Central South University
2023-2025
Children's Hospital of Fudan University
2023-2025
King University
2025
Zhengzhou Children's Hospital
2025
Zhengzhou University
2025
Imaging Center
2022-2025
An efficient yttrium-catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium-sized lactams. Furthermore, mechanistic rationale for this novel cascade reaction is well supported by variety control experiments.
Ulcerative colitis (UC) is an inflammatory bowel disease that difficult to cure, with rising incidence in recent decades. Probiotics have become a new strategy for UC treatment. In this study, we chose 2 multisource probiotics, Lactobacillus plantarum ZDY2013 from acid beans and Bifidobacterium bifidum WBIN03 infant feces, mixture of both, investigate the anti-inflammatory antioxidant effect on H2O2-induced oxidative damage HT-29 cell model dextran sodium sulfate (DSS)-induced mice. Compared...
An electric field promotes an unprecedented stepwise Diels-Alder cycloaddition reaction mechanism.
Upconversion luminescent materials (UCLMs) have garnered significant attention due to their broad potential applications in fields such as display technology, biological imaging, and optical sensing. However, optimizing crystal phase morphology remains a challenge. This study systematically investigates the effects of transformation control on upconversion properties K3GaF6:Er3+. By comparing different synthesis methods, we found that hydrothermal method effectively facilitated NaxK3-xGaF6...
Abstract An efficient yttrium‐catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium‐sized lactams. Furthermore, mechanistic rationale for this novel cascade reaction is well supported by variety control experiments.
Near-infrared-responsive liquid crystal elastomers are very interesting intelligent deformable materials, which have been intensively studied in many fields such as bionics, actuators, and microrobots. However, the organic near-infrared substances used still limited. Herein, we synthesized a light-absorbing diol, has strong absorption range of 700–900 nm excellent photothermal stability under irradiation (808 nm). Subsequently, polyurethane-based elastomer developed. The obtained displayed...
Background: Nasopharyngeal carcinoma (NPC) is characterized by high programmed death-ligand 1 (PD-L1) expression and abundant infiltration of non-malignant lymphocytes, which renders patients potentially suitable candidates for immune checkpoint blockade therapies. Palate, lung, nasal epithelium clone (PLUNC) inhibit the growth NPC cells enhance cellular apoptosis differentiation. Currently, relationship between PLUNC (as a tumor-suppressor) PD-L1 in unclear.Methods: We collected clinical...
Therapeutic strategies aimed at harnessing anti-tumor immunity are being intensively investigated as they show promising results in cancer treatment. The PD-1/ PD-L1 pathway is an essential target for restoring functional immune response. BRD7 a candidate tumor suppressor gene and nuclear transcription factor of nasopharyngeal carcinoma (NPC) which was cloned our laboratory. In this paper, we reported that the strongly associated with good prognosis NPC patients negatively regulated...
A central goal of chemical mechanism research is to provide a comprehensive interpretation reaction pathways clarify the evolution patterns reactions. In this work, we present an unprecedented monitoring elementary SN1 solvolysis on in-situ real-time single-molecule electrical detection platform. Through precise control oriented external electric field, capture two short-lived protonated intermediates at level and elucidate their roles in reaction. Both temperature- isotope-dependent...
Abstract A central goal of chemical mechanism research is to provide a comprehensive interpretation reaction pathways clarify the evolution patterns reactions. In this work, we present an unprecedented monitoring elementary S N 1 solvolysis on in situ real‐time single‐molecule electrical detection platform. Through precise control oriented external electric fields, capture two short‐lived protonated intermediates at level and elucidate their roles reaction. Both temperature‐...
Advancements in molecular electronics focus on single molecules as key components to create stable and functional devices that meet the requirements of device miniaturization function exploration. However, pioneering concept a diode, all single-molecule rectifiers reported previously are limited by their modest rectification ratios, owing electron transmission off-state, highlighting imperative for performance enhancements. Here, we demonstrate unique method capable realizing reproducible...
Abstract Reaction mechanism studies typically involve the characterization of products, and intermediates are often characterized by (sub)millisecond techniques, such as nuclear magnetic resonance, while femto/attosecond spectroscopies used to elucidate evolution transition states electron dynamics. However, due lack detection techniques in microsecond nanosecond range, well emergent complexity with increasing scale, most proposed have not yet been detected, which significantly hinders...
The enrichment of deep coalbed methane (CBM) in the Jiaxian block Ordos Basin is strongly influenced by sealing capacity coal seam roofs and floors, which play a pivotal role CBM preservation under conditions high temperature pressure. Despite its importance, mechanisms underlying remain poorly understood, their quantitative evaluation rarely explored. This study starts from influence gas transport channels, summarizes key factors that affect capability. And it addresses these gaps...
An accurate single-molecule kinetic isotope effect (sm-KIE) was applied to circumvent the inherent limitation of conventional ensemble KIE by using graphene–molecule–graphene junctions. In situ monitoring reaction trajectories in real time with high temporal resolution has capability characterize deeper information brought KIE. The C–O bond cleavage and C–C formation transition state (TS) were observed Claisen rearrangement through secondary effect, demonstrating detection sensitivity...
Abstract A robust single‐molecule memristor is prepared by covalently integrating one phenol molecule with multiple binding sites into nanogapped graphene electrodes. Multilevel resistance switching realized the electric‐field‐manipulated reconfiguration of acyl moiety on center, that is, Fries rearrangement. In situ measurements reaction trajectories an initial single substrate and intermediate break through limitation macroscopic experiments, therefore unveiling both intramolecular...
Precise tuning of chemical reactions with predictable and controllable manners, an ultimate goal chemists desire to achieve, is valuable in the scientific community. This tunability necessary understand regulate transformations at both macroscopic single-molecule levels meet demands potential application scenarios. Herein, we realise accurate a Mizoroki-Heck reaction via applying gate voltages as well complete deciphering its detailed intrinsic mechanism by employing in-situ electrical...
A robust single-molecule light-emitting diode (SM-LED) with high color purity, linear polarization, and efficiency tunability is prepared by covalently integrating one fluorescent molecule into nanogapped graphene electrodes. Furthermore, Förster resonance energy transfer from the electroluminescent center to different accepters achieved through rational molecular engineering, enabling construction of a multicolor SM-LED. All these characterizations are accomplished in photoelectrical...