A5101725133- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Erythrocyte Function and Pathophysiology
- RNA Interference and Gene Delivery
- Asymmetric Synthesis and Catalysis
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Organometallic Complex Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Hepatitis B Virus Studies
- Cerebrovascular and Carotid Artery Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Carbon dioxide utilization in catalysis
- Nitric Oxide and Endothelin Effects
- Oxidative Organic Chemistry Reactions
- NF-κB Signaling Pathways
- interferon and immune responses
- Vascular Malformations Diagnosis and Treatment
- Cell Adhesion Molecules Research
Kyushu University
1994-2025
Tokyo University of Pharmacy and Life Sciences
2015-2024
Niigata University Medical and Dental Hospital
2024
Osaka University of Pharmaceutical Sciences
2021-2024
Ajinomoto (Japan)
2024
Suzuki (Japan)
2024
Fukuoka City Hospital
2022-2023
Anjo Kosei Hospital
2023
Osaka University
1998-2022
Niigata University
2022
Apoptotic cells expose phosphatidylserine and are swiftly engulfed by macrophages. Milk fat globule epidermal growth factor (EGF) 8 (MFG-E8) is a protein that binds to apoptotic recognizing enhances the engulfment of We report tingible body macrophages in germinal centers spleen lymph nodes strongly express MFG-E8. Many lymphocytes were found on MFG-E8-/- macrophages, but they not efficiently engulfed. The mice developed splenomegaly, with formation numerous centers, suffered from...
Hematopoietic stem cells (HSCs) reside in specialized bone marrow (BM) niches regulated by the sympathetic nervous system (SNS). Here, we have examined whether mononuclear phagocytes modulate HSC niche. We defined three populations of BM that include Gr-1hi monocytes (MOs), Gr-1lo MOs, and macrophages (MΦ) based on differential expression Gr-1, CD115, F4/80, CD169. Using MO MΦ conditional depletion models, found reductions led to reduced CXCL12 levels, selective down-regulation retention...
To elucidate the cellular mechanism by which angiotensin II (ANG II) induces cardiac hypertrophy, we investigated possible autocrine/paracrine role of endogenous endothelin-1 (ET-1) in ANG II-induced hypertrophy neonatal rat cardiomyocytes use synthetic ET-1 receptor antagonist and antisense oligonucleotides to preproET-1 (ppET-1) mRNA. Northern blot analysis situ hybridization revealed that ppET-1 mRNA was expressed cardiomyocytes, but, a lesser extent, nonmyocytes as well. upregulated...
We examined whether apoptosis occurs in cardiomyocytes by hypoxia vitro. Neonatal rat and nonmyocytes were cultured 95% N2-5% CO2 atmosphere to produce hypoxic conditions. DNA fragmentation into integer multiples of the internucleosomal length was observed as early 12 hours, whereas did not show up 72 hours. induced also confirmed nick-end labeling situ. Messenger RNA for Fas antigen, a mediator apoptotic cell death, expressed both revealed Northern blotting situ hybridization. In condition,...
It has been believed that the Fas expressed on human peripheral blood T cells (PBT) is nonfunctional, because these are insensitive to agonistic anti-Fas/Apo-1 mAbs efficiently kill in vitro–activated and many Fas-expressing cell lines. Here, we demonstrate membrane-bound ligand (FasL) kills both fresh PBT, indicating PBT functional. In contrast, soluble FasL only latter. Naive umbilical cord do not express Fas, but can be induced by IFN-γ or a combination of IL-2 anti-CD28 mAb, after which...
Journal Article Human Fas ligand: gene structure, chromosomal location and species specificity Get access Tomohiro Takahashi, Takahashi Search for other works by this author on: Oxford Academic PubMed Google Scholar Masato Tanaka, Tanaka Johji Inazawa, Inazawa 1Department of Hygiene, Kyoto Prefectural University MedicineKamigyo-ku, 602, Japan Tatsuo Abe, Abe Takashi Suda, Suda Shigekazu Nagata Correspondence to: S. International Immunology, Volume 6, Issue 10, October 1994, Pages 1567–1574,...
Injection of apoptotic cells can induce suppression immune responses to cell-associated antigens. Here, we show that intravenous injection expressing a fragment myelin oligodendrocyte glycoprotein (MOG) reduced MOG-specific T cell response and prevented the development EAE. Since injected accumulated initially in splenic marginal zone (MZ), role macrophages MZ was examined using transgenic mice which these could be transiently deleted by diphtheria toxin (DT) injection. DT-treated became...
Lamina propria (LP) macrophages are constantly exposed to commensal bacteria, and refractory those antigens in an interleukin (IL)-10-dependent fashion. However, the mechanisms that discriminate hazardous invasion by bacteria from peaceful co-existence with them remain elusive. Here we show CD169(+) reside not at villus tip, but bottom-end of LP microenvironment. Following mucosal injury, recruit inflammatory monocytes secreting CCL8. Selective depletion or administration neutralizing...
The present study was aimed to test the role of endothelin-1 (ET-1) as a possible autocrine/paracrine growth factor for cardiac fibroblasts, and examine its interaction with natriuretic hormones. Expression preproET-1 (ppET-1) mRNA by cultured fibroblasts from neonatal rats demonstrated Northern blot analysis using cDNA rat ppET-1 probe. Angiotensin II (ANG II) ET-1 transiently (30 min) increased steady-state levels in fibroblasts. Both ANG significantly stimulated [3H] thymidine...
Apoptotic cells are rapidly phagocytosed by professional phagocytes, such as macrophages and dendritic cells. This process prevents the release of potentially noxious or immunogenic intracellular materials from dying cells, is thought to play a critical role for maintenance normal functions in surrounding tissues. Milk fat globule-EGF-factor 8 (MFG-E8), secreted activated immature links apoptotic promotes phagocytosis Here, we report that an MFG-E8 mutant, designated D89E, carrying point...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonylation of hydrocarbons via carbon-hydrogen activation catalyzed by RhCl(CO)(PMe3)2 under irradiationToshiyasu Sakakura, Touru Sodeyama, Koushi Sasaki, Keisuke Wada, and Masato TanakaCite this: J. Am. Chem. Soc. 1990, 112, 20, 7221–7229Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://doi.org/10.1021/ja00176a022RIGHTS & PERMISSIONSArticle...
Abstract Apoptotic cell clearance by dendritic cells (DCs) plays a crucial role in the maintenance of self-tolerance. In spleen, CD8α+ DCs are thought to be responsible for this phenomenon phagocytosing circulating apoptotic cells. However, as believed predominantly localized T zone, it remains unclear how these phagocytose blood-borne accumulated marginal zone (MZ). study, we identified subpopulation tolerance induction cell-associated Ags. Among splenic DCs, CD103+,CD207+ subset was...