A5016225060- Marine Toxins and Detection Methods
- Synthetic Organic Chemistry Methods
- Microwave Engineering and Waveguides
- Oxidative Organic Chemistry Reactions
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
- Cyclization and Aryne Chemistry
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- Advanced Antenna and Metasurface Technologies
- Viral Infections and Immunology Research
- Acoustic Wave Resonator Technologies
- X-ray Diffraction in Crystallography
- Breast Cancer Treatment Studies
- Antenna Design and Analysis
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Cardiomyopathy and Myosin Studies
- Microwave and Dielectric Measurement Techniques
- Nitric Oxide and Endothelin Effects
- Cancer Treatment and Pharmacology
Inoue Hospital
2012-2025
Nagoya University
2015-2024
Tokyo Women's Medical University
2009-2020
Tokyo Women's Medical University Hospital
2008-2016
Yamaguchi University
2013
Okayama University
2006-2013
Okayama Shoka University
2011
Kitami Institute of Technology
2011
Chulabhorn Research Institute
2011
National Tsing Hua University
2011
We examined whether apoptosis occurs in cardiomyocytes by hypoxia vitro. Neonatal rat and nonmyocytes were cultured 95% N2-5% CO2 atmosphere to produce hypoxic conditions. DNA fragmentation into integer multiples of the internucleosomal length was observed as early 12 hours, whereas did not show up 72 hours. induced also confirmed nick-end labeling situ. Messenger RNA for Fas antigen, a mediator apoptotic cell death, expressed both revealed Northern blotting situ hybridization. In condition,...
Objective To elucidate the direct role of human T cells in induction osteoclastogenesis rheumatoid arthritis (RA), by studying monocytes and pathogenetic roles receptor activator nuclear factor κB ligand (RANKL), RANK, osteoprotegerin (OPG). Methods Synovial tissue obtained at total knee replacement was stained immunohistologically using anti-RANKL, CD3, CD4 antibodies. Synovial fluid from patients with RA, osteoarthritis (OA), gout, or trauma. Concentrations soluble form RANKL...
To elucidate the direct role of human T cells in induction osteoclastogenesis rheumatoid arthritis (RA), by studying monocytes and pathogenetic roles receptor activator nuclear factor kappaB ligand (RANKL), RANK, osteoprotegerin (OPG).Synovial tissue obtained at total knee replacement was stained immunohistologically using anti-RANKL, CD3, CD4 antibodies. Synovial fluid from patients with RA, osteoarthritis (OA), gout, or trauma. Concentrations soluble form RANKL (sRANKL) OPG synovial were...
Dielectric materials are continuing to play a very important role in the microwave communication systems. These key realization of low-loss temperature-stable resonators and filters for satellite broadcasting equipment, many other devices. High dielectric-constant critical miniaturization wireless systems, both terminals base-stations, as well handsets. In this paper, sequential evolution dielectric applications devices will be reviewed. This includes waveguides, ceramic materials,...
Tetrodotoxin, a toxic principle of puffer fish poisoning, is one the most famous marine natural products because complex structure having many functional groups and its potent biological activity leading to death. Since elucidation in 1964, this toxin has been recognized as formidable target molecule for total synthesis. We have recently achieved first asymmetric synthesis from 2-acetoxy-tri-O-acetyl-d-glucal chiral starting material. The highly hydroxylated cyclohexane ring was constructed...
Even though tetrodotoxin (TTX) is a widespread toxin in marine and terrestrial organisms, very little known about the biosynthetic pathway used to produce it. By describing chemical structures of natural analogs TTX, we can start identify some precursors that might be important for TTX biosynthesis. In present study, an analog 5,11-dideoxyTTX, was identified first time sources, ovary pufferfish pharynx flatworm (planocerid sp. 1), by comparison with totally synthesized (−)-5,11-dideoxyTTX,...
Background —Remodeling of the coronary artery lesions in Kawasaki disease has been observed longitudinal angiographic studies. However, mechanisms such remodeling have not yet elucidated. Methods and Results —We examined formalin-fixed specimens arteries immunohistochemically by using antibodies against vascular growth factors (GFs) their receptors 7 children with disease, 9 no 3 adults atherosclerosis. In thickened intima at stenotic sites recanalized vessels extensive expression GFs, as...
Tenascin-C (TNC), an extracellular matrix glycoprotein, plays important roles in tissue remodeling. TNC is not normally expressed adults but reappears under pathologic conditions. The present study was designed to clarify the contribution of ventricular remodeling after myocardial infarction. We examined expression experimental infarction rat by immunohistochemistry and situ hybridization. Within 24 hours permanent coronary ligation, interstitial fibroblasts border zone started express mRNA....
Background Excess amounts of NO produced by an inducible synthase (iNOS) in response to cytokines may be cytotoxic and can destructive tissue. We investigated the role development myocardial damage effects aminoguanidine (AG), inhibitor iNOS, on experimental autoimmune myocarditis rats. Methods Results Autoimmune was induced 20 Lewis rats injection porcine cardiac myosin. Ten were administered AG. The severity evaluated measuring size myocarditic lesion serum levels CK-MB. Serum determined...
An efficient and convenient method for one step conversion of trimethylsilylacetylenes into haloacetylenes has been developed. This is sufficiently mild to apply a variety substrates having many kinds functional group. The validity this demonstrated in the synthesis simple model compound esperamicin/calicheamicin aglycon.
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTImproved Conditions for Facile Overman Rearrangement1Toshio Nishikawa, Masanori Asai, Norio Ohyabu, and Minoru IsobeView Author Information Laboratory of Organic Chemistry, School Bioagricultural Sciences, Nagoya University, Chikusa, 464-01, Japan Cite this: J. Org. Chem. 1998, 63, 1, 188–192Publication Date (Web):January 9, 1998Publication History Received28 July 1997Published online9 January 1998Published inissue 1...
Myocardial fat is often seen at cardiac computed tomography (CT) and magnetic resonance (MR) imaging of healthy adults patients with myocardial diseases. Physiologic develops aging commonly CT in the anterolateral right ventricular (RV) free wall RV outflow tract normal or thickened myocardium a normal-sized elderly patients. Pathologic conditions include healed infarction (MI); arrhythmogenic cardiomyopathy dysplasia (ARVC); others, such as lipoma, lipomatous hypertrophy interatrial septum,...
Background: Myocarditis (MC) is an important cause of cardiac dysfunction in children. Fulminant MC sometimes fatal, and sequelae may develop during follow-up. We conducted a nationwide survey to determine the clinico-epidemiological features Japanese children adolescents. Methods Results: Survey questionnaires were mailed 627 hospitals, which asked if they had treated patients aged between 1 month 17 years period from January 1997 through December 2002. Responses collected until 2005, data...
Abstract Tenascin‐C (TNC) is an extracellular matrix protein which appears at active sites of tissue remodelling during embryogenesis or cancer invasion. In normal heart, TNC only present the early stages development but reappears in pathological states. This study examined diagnostic value for assessing disease activity myocarditis. Expression was myosin‐induced autoimmune myocarditis mouse models. Sequential changes amount, localization and producing cells were analysed by reverse...
The toxic principle of puffer-fish poison, (−)-tetrodotoxin (1), has been recognized as a formidable synthetic target since its structure elucidation in 1964. An efficient total synthesis 1 via the intermediate 2, which was used previously for 11-deoxytetrodotoxin, is described. Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460293_s.pdf or from author. Please note: publisher not responsible content functionality any supporting...
To elucidate the intracellular localization of atrial natriuretic peptide (ANP) and brain (BNP) in human cardiac myocytes, an immunocytochemical study was carried out by a double immunogold technique using antisera highly specific for ANP BNP. Surgical autoptic tissue specimens heart were studied. In localized almost all secretory granules, whereas BNP colocalized with some granules. Although very few granules observed ventricular colocalization basically same as myocytes. No immunoreactive...
C-Glycosidation is of great significance in the organic synthesis optically active materials, since it allows introduction carbon chains to sugar chirons and use nuclei as a chiral pool well source. Silylacetylenes are sufficiently reactive form ‘sugar acetylenes’ for selective various acetylenic groups an alpha-axial manner at anomeric position D-hexopyranose rings. 1,4-Anti induction, on other hand, gives different stereochemical outcome case C-glycosidation pentopyranose glycals. The...
A precise measurement method for the temperature coefficient of dielectric resonator material was developed. The error decreased from 0.5 ppm/°C to 0.05 compared with conventional method. This made techniques improving stability possible, such as filters, multiplexer and oscillators.
Background and Purpose The development of subtype‐selective ligands to inhibit voltage‐sensitive sodium channels (VSSCs) has been attempted with the aim developing therapeutic compounds. Tetrodotoxin (TTX) is a toxin from pufferfish that strongly inhibits VSSCs. Many TTX analogues have identified marine terrestrial sources, although their specificity for particular VSSC subtypes not investigated. Herein, we describe binding 11 human Na v 1.1–Na 1.7. Experimental Approach Each subtype was...
Tetrodotoxin (TTX, 1) is a potent neurotoxin that widely found in both terrestrial and marine animals; however, the biosynthetic pathway genes for TTX have not yet been elucidated. Previously, we proposed originated from monoterpene; this hypothesis was based on structures of cyclic guanidino compounds are commonly toxic newts. However, these detected organisms. Instead, series deoxy analogues were thus, further screened TTX-related animals. Herein, report seven novel spiro bicyclic 2-8...
Cats anoint themselves with plant metabolites that confer mosquito repellence.
症例は68歳,男性.胸腔鏡補助下にて右下葉切除とリンパ節郭清を施行した.術後2日目にドレーンを抜去,3日目より右前胸部に狭窄音が出現した.CT検査では右上葉,中葉気管支の狭窄及び右上葉に浸潤影,すりガラス影を認め,上葉が背側,中葉が腹側に位置していた.また,中下葉間を切離した際の中葉のステープルラインを上中葉間に認めた.気管支鏡検査では右上葉及び中葉気管支入口部に軽度の狭窄を認め,中葉捻転を疑い再手術を施行した.中葉は気管支を軸に90度時計方向に捻転,上葉が背側,中葉が腹側に位置しており中葉捻転と診断,捻転解除を施行した.下葉切除後にも中葉捻転が起こりうること,中葉捻転では中葉以外の部位に異常を認める場合があることを認識しておくことが重要であると考えられた.また,診断にはステープルラインの位置に着目すること,治療方針決定には造影CT検査が有用であると考えられた.