A5069728869- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Cancer Cells and Metastasis
- Platelet Disorders and Treatments
- Circadian rhythm and melatonin
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dietary Effects on Health
- Blood disorders and treatments
- Multiple Myeloma Research and Treatments
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- Phagocytosis and Immune Regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
Kyushu University
2015-2025
Kyushu University Hospital
2015-2025
Albert Einstein College of Medicine
2010-2017
California Institute for Regenerative Medicine
2014
Institute for Stem Cell Biology and Regenerative Medicine
2013
Yeshiva University
2012-2013
Institute of Cell Biology
2013
Children's Hospital of Philadelphia
2013
Icahn School of Medicine at Mount Sinai
2008-2010
Tisch Hospital
2009
The intermediate filament protein Nestin labels populations of stem/progenitor cells, including self-renewing mesenchymal stem cells (MSCs), a major constituent the hematopoietic cell (HSC) niche. However, intracellular location prevents its use for prospective live isolation. Hence it is important to find surface markers specific Nestin+ cells. In this study, we show that expression PDGFRα and CD51 among CD45− Ter119− CD31− mouse bone marrow (BM) stromal characterizes large fraction...
How HSCs populate the fetal liver Hematopoietic stem cells (HSCs) undergo dramatic expansion in before migrating to their definitive site bone marrow. Khan et al. identify portal vessel–associated Nestin + NG2 pericytes as critical HSC niche components (see Perspective by Cabezas-Wallscheid and Trumpp). The vessel expand according fractal geometries, suggesting that cells—rather than factors expressed niche—drive proliferation. After birth, arterial vessels transform into veins, lose...
Neutrophils are highly motile leukocytes, and they play important roles in the innate immune response to invading pathogens. Neutrophil chemotaxis requires Rac activation, yet activators functioning downstream of chemoattractant receptors remain be determined. We show that DOCK2, which is a mammalian homologue Caenorhabditis elegans CED-5 Drosophila melanogaster Myoblast City, regulates motility polarity during neutrophil chemotaxis. Although DOCK2-deficient neutrophils moved toward source,...
Acute graft-versus-host disease (GVHD) results from the attack of host tissues by donor allogeneic T cells and is most serious limitation hematopoietic cell transplantation (allo-HCT). Host antigen-presenting are thought to control priming alloreactive induction acute GVHD after allo-HCT. However, whereas role DC in has been established, contribution macrophages not clearly addressed. We show that, contrast DC, reducing macrophage pool recipient mice increased expansion aggravated mortality...
Compounds targeting the circadian clock have been identified as potential treatments for clock-related diseases, including cancer. Our cell-based phenotypic screen revealed uncharacterized clock-modulating compounds. Through affinity-based target deconvolution, we GO289, which strongly lengthened period, a potent and selective inhibitor of CK2. Phosphoproteomics multiple phosphorylation sites inhibited by GO289 on proteins, PER2 S693. Furthermore, exhibited cell type-dependent inhibition...
The activation of β-catenin plays critical roles in normal stem cell function, and, when aberrantly activated, the maintenance and enhancement cancer stemness many solid cancers. Aberrant is also observed acute myeloid leukemia (AML), crucially contributes to self-renewal propagation leukemic cells (LSCs) regardless mutations contrast with such tumors. In this study, we showed that AML-specific autocrine loop comprised T-cell immunoglobulin mucin-3 (TIM-3) its ligand, galectin-9 (Gal-9),...