A5052639161- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Systemic Lupus Erythematosus Research
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Axon Guidance and Neuronal Signaling
- Hemoglobin structure and function
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Colorectal Cancer Treatments and Studies
- Protein Kinase Regulation and GTPase Signaling
- Neonatal Health and Biochemistry
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
Kyushu University
2012-2023
Saitama International Medical Center
2004-2014
Fukuoka University
2007-2014
National Center for Global Health and Medicine
2002-2012
Istituto Giannina Gaslini
2010
Ontario Institute for Cancer Research
1994-2010
Center for Global Health
2002-2010
Montefiore Medical Center
2008
Albert Einstein College of Medicine
2008
University Medical Center Utrecht
2006
Point mutations that activate the Ki- ras proto-oncogene are present in about 50 percent of human colorectal tumors. To study functional significance these mutations, activated genes two colon carcinoma cell lines, DLD-1 and HCT 116, were disrupted by homologous recombination. Compared with parental cells, cells at gene morphologically altered, lost capacity for anchorage-independent growth, grew more slowly both vitro nude mice, showed reduced expression c- myc . Thus, plays a key role...
The requirements with respect to HLA compatibility and the relative importance of matching for individual class I II alleles in transplantation hematopoietic stem cells from unrelated donors have not yet been established.
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a high-risk infectious pathogen. In the proposed model of failure, SARS-CoV down-regulates its receptor, angiotensin-converting enzyme 2 (ACE2), but mechanism involved unknown. We found that spike protein (SARS-S) induced TNF-α-converting (TACE)-dependent shedding ACE2 ectodomain. The modulation TACE activity by SARS-S depended on cytoplasmic domain ACE2, because deletion mutants lacking carboxyl-terminal region did not induce or...
Following the decision to hold their next full meeting after 14th International Histocompatibility Workshop in 2005, WHO Nomenclature Committee for Factors of HLA System has decided publish an interim report listing updated tables alleles including those assigned since publication last 2002 (1). The named during period follow principles established previous reports (1–17). As emphasized reports, there are required conditions acceptance new sequences official names. Where a sequence is...
Personalized cancer medicine is based on the concept that targeted therapies are effective subsets of patients whose tumors carry specific molecular alterations. Several mammalian target rapamycin (mTOR) inhibitors in preclinical or clinical trials for cancers, but basis sensitivity resistance to these among largely unknown. Here we have identified oncogenic variants phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) and KRAS as determinants response mTOR inhibitor everolimus....
Targeted disruption of the single mutant K- ras allele in two human colorectal carcinoma cell lines (DLD-1 and HCT-116) leads to loss tumorigenic competence nude mice with retention ability grow indefinitely monolayer culture. Because expression oncogene these is associated marked up-regulation vascular endothelial growth factor/vascular permeability factor (VEGF/VPF), we sought determine whether this potent angiogenesis inducer plays a role K-ras-dependent competence. Transfection VEGF 121...
Genetic factors have been suggested to contribute the etiology of moyamoya disease. The authors previously reported an association between disease and several alleles for human leukocyte antigens (HLA). To further specify genetic component disease, a linkage study using markers on chromosome 6, where HLA gene is located, was performed. 15 microsatellite 6 were studied in 20 affected sibling pairs. From identical-by-descent analysis these markers, allele with possible identified. Sharing...
Neutrophils are highly motile leukocytes, and they play important roles in the innate immune response to invading pathogens. Neutrophil chemotaxis requires Rac activation, yet activators functioning downstream of chemoattractant receptors remain be determined. We show that DOCK2, which is a mammalian homologue Caenorhabditis elegans CED-5 Drosophila melanogaster Myoblast City, regulates motility polarity during neutrophil chemotaxis. Although DOCK2-deficient neutrophils moved toward source,...