A5010799165- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Melanoma and MAPK Pathways
- Nanoplatforms for cancer theranostics
- HER2/EGFR in Cancer Research
- Brain Metastases and Treatment
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- T-cell and B-cell Immunology
- Vascular Tumors and Angiosarcomas
University of Toronto
2016-2025
Sunnybrook Health Science Centre
2016-2025
Sunnybrook Research Institute
2015-2024
Health Sciences Centre
2008-2023
Moores Cancer Center
2023
Institute of Biophysics
2023
Sunnybrook Hospital
2012-2020
Canada Research Chairs
2017
Georg Speyer Haus
2013-2016
Technion – Israel Institute of Technology
2009-2016
Various conventional chemotherapeutic drugs can block angiogenesis or even kill activated, dividing endothelial cells. Such effects may contribute to the antitumor efficacy of chemotherapy in vivo and delay prevent acquisition drug-resistance by cancer We have implemented a treatment regimen that augments potential antivascular chemotherapy, is devoid obvious toxic side effects, obstructs development drug resistance tumor Xenografts 2 independent neuroblastoma cell lines were subjected...
Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and β1-6-linked branching complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAcβ1-6Manα1-6Manβ1-). However, little is known about the relevant glycoproteins or how these transformation-related oligosaccharide biosynthesis may affect malignant phenotype. Here it reported that glycoprotein, gp130, major target expression...
The Fourth Metronomic and Anti-angiogenic Therapy Meeting was held in Milan 24-25 June 2014. meeting a true translational where researchers clinicians shared their results, experiences, insights order to continue gathering useful evidence on metronomic approaches. Several speakers emphasised that exact mechanisms of action, best timing, optimal dosage are still not well understood the field would learn lot from ancillary studies performed during clinical trials chemotherapies. From...
Activated EGF receptor (EGFR) plays an oncogenic role in several human malignancies. Although the intracellular effects of EGFR are well studied, its ability to induce and modulate tumor angiogenesis is less understood. We found previously that can be shed from cancer cells as cargo membrane microvesicles (MVs), which interact with surfaces other cells. Here we report MVs produced by harboring activated (A431, A549, DLD-1) taken up cultured endothelial cells, they elicit EGFR-dependent...
The contribution of bone marrow-derived circulating endothelial progenitor cells (CEPs) to tumor angiogenesis has been controversial, primarily because their low numbers in blood vessels untreated tumors. We show that treatment tumor-bearing mice with vascular disrupting agents (VDAs) leads an acute mobilization CEPs, which home the viable rim characteristically remains after such therapy. Disruption this CEP spike by antiangiogenic drugs or genetic manipulation resulted marked reductions...
For more than 50 years, a major goal of research in cancer therapeutics has been to develop universally effective agents that render cells sensitive cytotoxic chemotherapy without substantially increasing toxicity normal cells. The results recent clinical trials indicate certain antiangiogenic drugs may produce this long-sought effect. Here, I describe three distinct mechanisms help explain the chemosensitizing activity these drugs: normalizing tumor vasculature, preventing rapid cell...
Recent studies have demonstrated the importance of E-cadherin, a homophilic cell–cell adhesion molecule, in contact inhibition growth normal epithelial cells. Many tumor cells also maintain strong intercellular adhesion, and are growth-inhibited by cell– cell contact, especially when grown three-dimensional culture. To determine if E-cadherin could mediate contact-dependent nonadherent EMT/6 mouse mammary carcinoma that lack we transfected these with an exogenous expression vector. resulted...