A5059986913- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Glycosylation and Glycoproteins Research
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Cell Adhesion Molecules Research
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- HIV Research and Treatment
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- Genomic variations and chromosomal abnormalities
- Drug Transport and Resistance Mechanisms
University of Cambridge
2015-2024
Wellcome Trust
1998-2016
Addenbrooke's Hospital
2003-2014
Oslo University Hospital
1993-2014
Institute for Medical Research
2013
Papworth Hospital
2012
King's College London
2012
Pulmonary Associates
2012
Amsterdam UMC Location University of Amsterdam
2011
Japan Patent Office
2010
Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply blood due to failure trophoblast invasion. There evidence that condition has immunological basis. The only known polymorphic histocompatibility antigens on fetal are HLA-C molecules. We tested idea recognition these molecules by killer immunoglobulin receptors (KIRs) maternal decidual NK cells key factor development preeclampsia. Striking differences were observed when ligand: receptor pairs...
The ≈1-Mb leukocyte receptor complex at 19q13.4 is a key polymorphic immunoregion containing all of the natural killer-receptor KIR and related ILT genes. When organization was compared from two haplotypes, gene content in region varied dramatically, with framework loci flanking regions widely variable content. genes were more stable number except for 6, which present only one haplotype. Analysis Alu repeats comparison sequences, are over 90% identical, consistent recent origin. genesis...
Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone calreticulin, interact transporter associated antigen processing (TAP) through a molecule called tapasin. The molecular cloning of tapasin revealed it to be transmembrane glycoprotein encoded by an MHC-linked gene. It is member immunoglobulin superfamily probable cytoplasmic retention signal. Up four MHC I–tapasin complexes were found bind each TAP molecule. Expression...
Following the decision to hold their next full meeting after 14th International Histocompatibility Workshop in 2005, WHO Nomenclature Committee for Factors of HLA System has decided publish an interim report listing updated tables alleles including those assigned since publication last 2002 (1). The named during period follow principles established previous reports (1–17). As emphasized reports, there are required conditions acceptance new sequences official names. Where a sequence is...
DC-SIGN is a C-type lectin, highly expressed on the surface of immature dendritic cells (DCs), that mediates efficient infection T in trans by its ability to bind HIV-1, HIV-2, and SIV. In addition, adhesion molecules surfaces naïve endothelium also suggests involvement T-cell activation DC trafficking. To gain further insights into range expression potential functions DC-SIGN, we performed detailed analysis adult fetal tissues analyzed regulated cultured DCs macrophages. First, show...
The large-scale chromatin organization of the major histocompatibility complex and other regions chromosome 6 was studied by three-dimensional image analysis in human cell types with differences transcriptional activity. Entire gene clusters were visualized fluorescence situ hybridization multiple locus-specific probes. Individual genomic showed distinct configurations relation to terrritory. Large loops containing several megabases DNA observed extending outwards from surface domain defined...