Jethro Herberg
A5073032257- Kawasaki Disease and Coronary Complications
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- Neonatal and Maternal Infections
- Emergency and Acute Care Studies
- Streptococcal Infections and Treatments
- Coronary Artery Anomalies
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Bacterial Identification and Susceptibility Testing
- Bacterial Infections and Vaccines
- Hematological disorders and diagnostics
- Complement system in diseases
- interferon and immune responses
- Antibiotic Use and Resistance
- Neonatal Respiratory Health Research
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Infectious Encephalopathies and Encephalitis
- Biosensors and Analytical Detection
- Viral Infections and Outbreaks Research
- Neonatal and fetal brain pathology
Imperial College London
2016-2025
St Mary's Hospital
2016-2024
Royal College of Paediatrics and Child Health
2021-2024
The London College
2024
MRC Unit the Gambia
2024
University of Zurich
2024
St Mary's Hospital
2020-2023
Wright Institute
2023
Imperial College Healthcare NHS Trust
2019-2023
St. Mary's Hospital
2020-2023
In communities with high rates of coronavirus disease 2019, reports have emerged children an unusual syndrome fever and inflammation.
Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes by HBV-specific CD8 cells has been assumed to be central mechanism causing both liver damage control. To understand role cytotoxic T in pathogenesis HBV infection, we used functional assays that require cell expansion vitro human histocompatibility leukocyte antigen (HLA)-peptide tetramers allow direct ex vivo quantification circulating liver-infiltrating cells. Two groups patients with persistent...
Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone calreticulin, interact transporter associated antigen processing (TAP) through a molecule called tapasin. The molecular cloning of tapasin revealed it to be transmembrane glycoprotein encoded by an MHC-linked gene. It is member immunoglobulin superfamily probable cytoplasmic retention signal. Up four MHC I–tapasin complexes were found bind each TAP molecule. Expression...
Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated severe acute respiratory coronavirus 2.We performed an international observational cohort study of clinical and outcome data regarding suspected MIS-C that had been uploaded by physicians onto a Web-based database. We used inverse-probability weighting generalized linear models evaluate intravenous immune globulin (IVIG) as reference, compared IVIG plus...
Improving the quality of hospital antibiotic use is a major goal WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed present data on patterns paediatric AWaRe be used for local national interventions.1-day point prevalence survey prescription were combined from two independent networks: Global Antimicrobial...
IMPORTANCEBecause clinical features do not reliably distinguish bacterial from viral infection, many children worldwide receive unnecessary antibiotic treatment, while infection is missed in others.OBJECTIVE To identify a blood RNA expression signature that distinguishes febrile children. DESIGN, SETTING, AND PARTICIPANTSFebrile presenting to participating hospitals the United Kingdom, Spain, Netherlands, and States between 2009-2013 were prospectively recruited, comprising discovery group...
BackgroundAlthough therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy low-income middle-income countries is unclear. We aimed to examine whether alongside optimal supportive intensive care moderate severe south Asia.MethodsWe did a multicountry open-label, randomised controlled trial seven tertiary units India, Sri Lanka, Bangladesh. enrolled infants born at 36 weeks of gestation with need for continued...
An outbreak of acute hepatitis unknown aetiology in children was reported Scotland1 April 2022 and has now been identified 35 countries2. Several recent studies have suggested an association with human adenovirus this outbreak, a virus not commonly associated hepatitis. Here we report detailed case–control investigation find between adeno-associated 2 (AAV2) infection host genetics disease susceptibility. Using next-generation sequencing, PCR reverse transcription, serology situ...
Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little known about determinants influencing outcome. We characterized children admitted with community-acquired sepsis European PICUs and studied risk factors mortality disability. Data were collected within collaborative Seventh Framework Programme (FP7)-funded EUCLIDS study, which a prospective multicenter cohort study aiming evaluate genetic susceptibility and/or severity in sepsis....
The Kobayashi score (KS) predicts intravenous immunoglobulin (IVIG) resistance in Japanese children with Kawasaki disease (KD) and has been used to select patients for early corticosteroid treatment. We tested the ability of KS predict IVIG coronary artery abnormalities (CAA) 78 treated KD our UK centre. 19/59 were non-responsive. This was not predicted by a high (11/19 non-responders, compared 26/40 responders, had ≥4; p=0.77). CAA (12/20 vs 25/39 normal echo p=0.78). Low albumin...
OBJECTIVES: To describe presentation, hospital course, and predictors of bad outcome in multisystem inflammatory syndrome children (MIS-C). METHODS: Retrospective data review a case series meeting the published definition for MIS-C who were discharged or died between March 1, 2020, June 15, from 33 participating European, Asian, American hospitals. Data collected through Web-based survey included clinical, laboratory, electrocardiographic, echocardiographic findings treatment management....
To date, there is no diagnostic test for Kawasaki disease (KD). Diagnosis based on clinical features shared with other febrile conditions, frequently resulting in delayed or missed treatment and an increased risk of coronary artery aneurysms.To identify a whole-blood gene expression signature that distinguishes children KD the first week illness from conditions.The case-control study comprised discovery group included training set validation comparator illness. The setting was pediatric...
Cellular intrinsic immunity, mediated by the expression of an array interferon-stimulated antiviral genes, is a vital part host defense. We have previously used bioinformatic screen to identify two genes (ISG) with poorly characterized function, interferon-induced protein 44 (IFI44) and 44-like (IFI44L), as potentially being important in respiratory syncytial virus (RSV) infection. Using overexpression systems, CRISPR-Cas9-mediated knockout, knockout mouse model, we investigated capability...
Background The prescription rate of antibiotics is high for febrile children visiting the emergency department (ED), contributing to antimicrobial resistance. Large studies at European EDs covering diversity in antibiotic and broad-spectrum prescriptions all are lacking. A better understanding variability its relation with viral or bacterial disease essential development implementation interventions optimise use. As part PERFORM (Personalised Risk assessment Febrile illness Optimise...
Appropriate treatment and management of children presenting with fever depend on accurate timely diagnosis, but current diagnostic tests lack sensitivity specificity are frequently too slow to inform initial treatment. As an alternative pathogen detection, host gene expression signatures in blood have shown promise discriminating several infectious inflammatory diseases a dichotomous manner. However, differential diagnosis requires simultaneous consideration multiple diseases. Here, we show...
Background Sepsis is defined as dysregulated host response to infection that leads life-threatening organ dysfunction. Biomarkers characterising the in sepsis are lacking. We aimed develop gene expression signatures predict dysfunction children with bacterial or viral infection. Methods This cohort study was done emergency departments and intensive care units of four hospitals Queensland, Australia, recruited aged 1 month 17 years who, upon admission, underwent a diagnostic test, including...
Importance Induced hypothermia, the standard treatment for hypoxic-ischemic encephalopathy (HIE) in high-income countries (HICs), is less effective low-income populations South Asia, who have highest disease burden. Objective To investigate differences blood genome expression profiles of neonates with HIE from an HIC vs Asia. Design, Setting, and Participants This case-control study analyzed data (1) a prospective observational involving moderate or severe underwent whole-body hypothermia...
To assess characteristics and outcomes of children with suspected or confirmed infection requiring emergency transport PICU admission to explore the association between 2024 Phoenix Sepsis Score (PSS) criteria mortality. Retrospective analysis curated data from a 2014-2016 multicenter cohort study. following in South East England, United Kingdom, April 2014 December 2016. Children 0-16 years old (n = 663) whom 444 (67%) had infection. None. The PSS was calculated as sum four individual organ...