Helena Brenes-Chacón
A5049906373- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- Congenital Diaphragmatic Hernia Studies
- Venomous Animal Envenomation and Studies
- Neonatal Respiratory Health Research
- Rabies epidemiology and control
- Pneumonia and Respiratory Infections
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Tracheal and airway disorders
- Mosquito-borne diseases and control
- Vaccine Coverage and Hesitancy
- Antibiotic Use and Resistance
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Child and Adolescent Health
- Hepatitis B Virus Studies
- Mechanical Circulatory Support Devices
- Parvovirus B19 Infection Studies
- Antibiotics Pharmacokinetics and Efficacy
- Cervical Cancer and HPV Research
- Clostridium difficile and Clostridium perfringens research
Costa Rican Department of Social Security
2019-2025
Hospital Nacional de Niños
2019-2025
Nationwide Children's Hospital
2020-2024
The Ohio State University
2023
Western University
2022
Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud
2021
Centers for Disease Control and Prevention
2021
Immunité et Cancer
2020
Universidad de Ciencias Medicas
2020
<h3>Background:</h3> SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought investigate risk factors for admission the intensive care unit (ICU) and explored changes disease severity over time. <h3>Methods:</h3> obtained data from chart reviews of younger than 18 years with confirmed or probable MIS-C who were admitted 15 hospitals Canada, Iran Costa Rica between Mar. 1, 2020, 7, 2021. Using multivariable analyses, we evaluated whether date other...
Abstract Background Respiratory syncytial virus (RSV) infection is associated with significant morbidity in infants. Risk factors for severe disease beyond the first 2 years of life have not been fully defined. Methods Children <5 hospitalized virologically confirmed RSV were identified over six respiratory seasons (10/2012–4/2018) and their medical records manually reviewed. Multivariable analyses performed to define age‐specific (<6, 6–24, >24–59 months) risk oxygen...
<ns4:p>Introduction Zero-dose children (ZDC) are defined as those that have never been reached by routine immunization services. In Latin America, almost 2.7 million infants younger than 1 year of age, incomplete vaccination schedules, and vaccine preventable diseases such measles or polio increase worldwide. ZDC reported to reside in high risk fragile settings, including remote-rural areas, urban slums, conflict-affected areas. Identifying the problem settings each country is mandatory...
Abstract Background Studies have analyzed the contribution of host and viral factors to RSV disease pathogenesis severity in children, but role RSV/viral co-detection is poorly understood. We investigated relationship between co-detection, loads, mucosal cytokine concentrations young children with acute respiratory infection (ARI). Methods enrolled a convenience sample previously healthy &lt; 2 years age ARI that were either hospitalized or managed as outpatients at large pediatric...
In August 2020, the World Health Assembly approved global strategy to eliminate cervical cancer, envisioning a world where it seizes be public health problem. The cancer elimination initiative reinforces commitment fulfilling rights of adolescent girls and women by reducing both economic inequities in poorest populations that have more limited access timely effective services. This improves quality life their families protecting them from disease causes disability preventing avoidable...
The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs low- and middle-income countries (LMICs). PROUD (Preventing RespiratOry virUs unDerdeveloped countries) Taskforce 24 RSV worldwide experts assessed key needs for prevention LMICs, including vaccine newer preventive measures.A global, survey-based study was undertaken 2021. An online questionnaire developed following three meetings the panellists wherein factors related to infection, its...
To identify risk factors for severe disease in children hospitalised SARS-CoV-2 infection.Multicentre retrospective cohort study.18 hospitals Canada, Iran and Costa Rica from 1 February 2020 to 31 May 2021.Children<18 years of age symptomatic PCR-positive infection, including multisystem inflammatory syndrome (MIS-C).Severity on the WHO COVID-19 Clinical Progression Scale was used ordinal logistic regression analyses.We identified 403 hospitalisations. Median 3.78 (IQR 0.53-10.77). At least...
ABSTRACT: Background and Objectives: Neurological involvement associated with SARS-CoV-2 infection is increasingly recognized. However, the specific characteristics prevalence in pediatric patients remain unclear. The objective of this study was to describe neurological a multinational cohort hospitalized SARS-CoV-2. Methods: This multicenter observational children <18 years age confirmed or multisystemic inflammatory syndrome (MIS-C) laboratory evidence children, admitted 15 tertiary...
Background: Age-dependent differences in clinical presentation and viral loads infants young children with respiratory syncytial virus (RSV) infection, their correlation disease severity are poorly defined. Methods: Previously healthy <2 years old mild (outpatients) severe (inpatients) RSV infection were enrolled measured by polymerase chain reaction nasopharyngeal swabs. Patients stratified age 0–<3, 3–6 >6–24 months, multivariable analyses performed to identify factors associated...
This cohort study evaluates respiratory syncytial virus (RSV)–related hospitalizations and disease severity from 2012 to 2023 in children younger than 5 years.
Coagulopathy and thrombosis associated with SARS-CoV-2 infection are well defined in hospitalized adults leads to adverse outcomes. Pediatric studies limited.An international multicentered (n = 15) retrospective registry collected information on the clinical manifestations of multisystem inflammatory syndrome (MIS-C) children from February 1, 2020 through May 31, 2021. This sub-study focused coagulopathy. Study variables included patient demographics, comorbidities, presentation, hospital...
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections in children around world. The post-pandemic era has resulted a notable increase reported cases RSV infections, co-circulation other viruses, shifts epidemiology, altered season timing, and increased healthcare demand. Low- middle-income countries are responsible for highest burden disease, contributing significantly to health expenses during seasons RSV-associated mortality children. Until recently,...
Although devastating acute effects associated with snake envenoming are well described, the long-term sequelae resulting from these envenomings have not been adequately addressed, especially in paediatric population. The aim of our study is to describe clinical characteristics among patients Costa Rica who developed secondary snakebite envenoming.Retrospective descriptive under 13 years were admitted a history recent at National Children's Hospital January 2001 December 2014.We enrolled 74...
Abstract BACKGROUND SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We investigated risk factors for severe disease and explored changes severity over time. METHODS Children up 17 years of age admitted March 1, 2020 through 7 th , 2021 15 hospitals Canada, Iran Costa Rica with confirmed or probable MIS-C were included. Descriptive analysis comparison by diagnostic criteria, country, admission date was performed. Adjusted absolute average risks (AR)...
Secondary bacterial infections following Viperidae snakebite envenomation in children are common. Among 75 patients admitted because of snakebites at the only pediatric hospital Costa Rica, 16 (21.3%) had a culture-confirmed secondary infection. Morganella morganii (37.5%), Aeromonas hydrophila (31.2%), and Providencia rettgeri (18.7%) were most common pathogens. Empiric prophylaxis is still recommended should be based on local etiological agents antimicrobial susceptibilities.
Background: Knowledge about neurological manifestations of SARS-CoV-2 in children is limited. We describe an international cohort hospitalized pediatric patients.Methods: This a multi-national observational study involving tertiary healthcare institutions Canada, Costa Rica and Iran. included patients 1 day-18 years admitted for any medical reason February 1, 2020-January 31, 2021 with laboratory evidence infection by RT-PCR or serological testing. Descriptive analyses logistic regression...
<ns4:p>Introduction Zero-dose children (ZDC) are defined as those that have never been reached by routine immunization services. In Latin America, almost 2.7 million infants younger than 1 year of age, incomplete vaccination schedules, and vaccine preventable diseases such measles or polio increase worldwide. ZDC reported to reside in high risk fragile settings, including remote-rural areas, urban slums, conflict-affected areas. Identifying the problem settings each country is mandatory...
Influenza behavior depends on several characteristics: the agent itself, host response, and environmental changes that determine seasonality, presentation, disease severity, lethality, intensity of contagion. Vulnerable populations, such as elderly, people with underlying diseases, incomplete vaccination status, can influence presentation epidemiology. These information are necessary for existing surveillance systems. Special human animal diseases is necessary, considering recent outbreaks...