A5009464778- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Viral gastroenteritis research and epidemiology
- Tracheal and airway disorders
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- Respiratory Support and Mechanisms
- Kawasaki Disease and Coronary Complications
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- Streptococcal Infections and Treatments
- Parvovirus B19 Infection Studies
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Cystic Fibrosis Research Advances
- interferon and immune responses
- Neonatal and Maternal Infections
- Antimicrobial Resistance in Staphylococcus
- Tuberculosis Research and Epidemiology
St. Jude Children's Research Hospital
2023-2025
Nationwide Children's Hospital
2015-2024
The Ohio State University
2015-2024
Immunité et Cancer
2011-2024
The Ohio State University Wexner Medical Center
2020-2024
University of Tennessee Health Science Center
2024
Universidad de Málaga
2018-2021
University of Mississippi Medical Center
2020
State Street (United States)
2020
American College of Allergy, Asthma and Immunology
2020
A T cell subset that emerges in blood after seasonal influenza vaccinations correlates with the development of protective antibody responses.
Abstract Each infectious agent represents a unique combination of pathogen-associated molecular patterns that interact with specific pattern-recognition receptors expressed on immune cells. Therefore, we surmised the blood cells individuals different infections might bear discriminative transcriptional signatures. Gene expression profiles were obtained for 131 peripheral samples from pediatric patients acute caused by influenza A virus, Gram-negative (Escherichia coli) or Gram-positive...
Background: The diagnosis of Kawasaki disease (KD) is often difficult to distinguish from HAdV. Objective: 1) To characterize the specific transcriptional profiles KD patients versus acute HAdV infection 2) determine whether molecular distance health (MDTH) score (a that reflects perturbation derived whole genome analysis) correlates with response therapy. Methods: Whole blood RNA samples collected in Tempus tubes were analyzed using Illumina chips and GeneSpring software 7.4 76 pediatric...
Background. Although the epidemiology of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has been explored in many investigations, management this emerging infection not well-studied. For non-methicillin-resistant skin and soft tissue abscesses, incision drainage is generally adequate therapy without use antibiotics, but established for CA-MRSA. Methods. Children presenting to Children’s Medical Center Dallas abscesses caused by culture-proved CA-MRSA were...
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections and hospitalizations in infants worldwide. Known risk factors, however, incompletely explain variability RSV disease severity, especially among healthy children. We postulate that severity infection influenced by modulation host immune response local bacterial ecosystem.To assess whether specific nasopharyngeal microbiota (clusters) are associated with distinct transcriptome profiles children...
In this study, Mejias and colleagues found that specific blood RNA profiles of infants with RSV LRTI allowed for diagnosis, better understanding disease pathogenesis, assessment severity. Please see later in the article Editors' Summary
BACKGROUND: The trends in hospitalization rates and risk factors for severe bronchiolitis have not been recently described, especially after the routine implementation of prophylaxis respiratory syncytial virus (RSV) infections. OBJECTIVES: To define burden hospitalizations related to RSV non-RSV a tertiary-care children's hospital from 2002 2007 identify associated with disease. METHODS: Medical records patients hospitalized were reviewed demographic, clinical, microbiologic, radiologic...
BackgroundRespiratory syncytial virus (RSV) infection is an important cause of pneumonia mortality in young children. However, clinical data for fatal RSV are scarce. We aimed to identify and socioeconomic characteristics children aged younger than 5 years with RSV-related using individual patient data.MethodsIn this retrospective case series, we developed online questionnaire obtain who died community-acquired between Jan 1, 1995, Oct 31, 2015, through leading research groups child...
<h3>Importance</h3> Young febrile infants are at substantial risk of serious bacterial infections; however, the current culture-based diagnosis has limitations. Analysis host expression patterns (“RNA biosignatures”) in response to infections may provide an alternative diagnostic approach. <h3>Objective</h3> To assess whether RNA biosignatures can distinguish aged 60 days or younger with and without infections. <h3>Design, Setting, Participants</h3> Prospective observational study involving...
The postacute sequelae of SARS-CoV-2 infection (PASC) has emerged as a long-term complication in adults, but current understanding the clinical presentation PASC children is limited.To identify diagnosed symptoms, health conditions, and medications associated with children.This retrospective cohort study used electronic records from 9 US children's hospitals for individuals younger than 21 years who underwent antigen or reverse transcriptase-polymerase chain reaction (RT-PCR) testing between...
This national study evaluated trends in illness severity among 82 798 children with coronavirus disease 2019 from March 1, 2020, to December 30, 2021.
Systemic onset juvenile idiopathic arthritis (SoJIA) represents up to 20% of arthritis. We recently reported that interleukin (IL) 1 is an important mediator this disease and IL-1 blockade induces clinical remission. However, lack specificity the initial systemic manifestations leads delays in diagnosis initiation therapy. To develop a specific diagnostic test, we analyzed leukocyte gene expression profiles 44 pediatric SoJIA patients, 94 patients with acute viral bacterial infections, 38...
ABSTRACT Airway epithelial cells (AECs) provide the first line of defense in respiratory tract and are main target viruses. Here, using oligonucleotide protein arrays, we analyze infection primary polarized human AEC cultures with influenza virus syncytial (RSV), show that immune response AECs is quantitatively qualitatively specific. Differentially expressed genes (DEGs) specifically induced by not RSV included those encoding interferon B1 (IFN-B1), type III interferons (interleukin 28A...
Background. Distinguishing between bacterial and viral lower respiratory tract infection (LRTI) remains challenging. Transcriptional profiling is a promising tool for improving diagnosis in LRTI. Methods. We performed whole blood transcriptional analysis 118 patients (median age [interquartile range], 61 [50–76] years) hospitalized with LRTI 40 age-matched healthy controls age, 60 [46–70] years). applied class comparisons, modular analysis, prediction algorithms to identify validate...
Background: Staphylococcus aureus remains the most common etiologic agent of acute osteomyelitis in children. Recently, methicillin-resistant S. (MRSA) has emerged as a major pathogen. Methods: Records all children admitted with from January 1999 to December 2003 were reviewed. For comparative analysis, study population was evenly distributed 2 periods: period A, June 2001; n = 113; and B, July 2001 2003; 177. In addition, clinical findings MRSA compared non-MRSA osteomyelitis, including...
Infection by RNA viruses is detected the host through Toll-like receptors or RIG-I-like receptors. and signal adaptors MyD88 MAVS, respectively, to induce type I IFNs (IFN-I) other antiviral molecules, which are thought be essential for activating adaptive immune system. We investigated role of these in innate responses against respiratory syncytial virus (RSV), a common human pathogen. Deletion Mavs abolished induction IFN-I proinflammatory cytokines RSV. Genome-wide expression profiling...