A5015889303- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Malaria Research and Control
- Pneumonia and Respiratory Infections
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Vaccine Coverage and Hesitancy
- Gut microbiota and health
- T-cell and B-cell Immunology
- Vibrio bacteria research studies
- Viral Infections and Immunology Research
- COVID-19 and Mental Health
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Receptor Mechanisms and Signaling
- Bacterial Infections and Vaccines
University of Michigan–Ann Arbor
2016-2025
Ann Arbor Center for Independent Living
2023
Michigan United
2015-2022
St. Jude Children's Research Hospital
2020
University of California, Berkeley
2007-2018
Sustainable Sciences Institute
2015-2018
University of Hong Kong
2018
Florida State University
2016
Ministerio de Salud
2015
Fogarty International Center
2009-2012
For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown enhance viral replication in vitro and severe disease animal models. Although suspected, such antibody-dependent enhancement not occur humans. Using multiple statistical approaches study long-term pediatric cohort Nicaragua, we show that risk is highest within narrow preexisting anti-DENV titers. By contrast, observe protection from all symptomatic at high Thus, immune correlates must be evaluated...
The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly due to altered antibody evasion properties deriving from their additional spike mutations. Here, we report that neutralization BQ.1, BQ.1.1, XBB, XBB.1 by sera vaccinees infected persons was markedly impaired, including individuals boosted with a WA1/BA.5 bivalent mRNA vaccine. Titers against were lower 13- 81-fold 66- 155-fold, respectively, far beyond what had been observed date. Monoclonal antibodies...
The rapid spread of dengue is a worldwide public health problem. In two clinical studies in Managua, Nicaragua, we observed an abrupt increase disease severity across several epidemic seasons virus serotype 2 (DENV-2) transmission. Waning DENV-1 immunity appeared to the risk severe subsequent DENV-2 infections after period cross-protection. coincided with replacement Asian/American NI-1 clade new clade, NI-2B. vitro analyses viral isolates from clades and analysis viremia patient blood...
Four dengue virus serotypes (DENV1-4) circulate globally, causing more human illness than any other arthropod-borne virus. Dengue can present as a range of clinical manifestations from undifferentiated fever to Fever severe, life-threatening syndromes. However, most DENV infections are inapparent. Yet, little is known about determinants inapparent versus symptomatic infection outcome. Here, we analyzed over 2,000 2004 2011 in prospective pediatric cohort study Managua, Nicaragua. Symptomatic...
Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates effect on duration viral shedding within household transmission Managua, Nicaragua, over 3 seasons (2015–2017). Symptomatic obese adults were shown to shed A 42% longer than nonobese (adjusted event time ratio [ETR], 1.42; 95% confidence interval [CI], 1.06–1.89); no association was observed with B...
The Zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (DENV1 -4) extend the closely related (ZIKV). We investigated prospective pediatric cohorts Nicaragua that experienced sequential DENV1 -3 (2004 2015), (2016 2017), and DENV2 (2018 2020) epidemics. Risk of symptomatic infection severe disease was elevated by one prior ZIKV infection, DENV or followed compared with being flavivirus-naïve. By contrast, multiple infections reduced risk....
BackgroundRespiratory syncytial virus (RSV) infection is an important cause of pneumonia mortality in young children. However, clinical data for fatal RSV are scarce. We aimed to identify and socioeconomic characteristics children aged younger than 5 years with RSV-related using individual patient data.MethodsIn this retrospective case series, we developed online questionnaire obtain who died community-acquired between Jan 1, 1995, Oct 31, 2015, through leading research groups child...
Zika virus (ZIKV) emerged in northeast Brazil 2015 and spread rapidly across the Americas, populations that have been largely exposed to dengue (DENV). The impact of prior DENV infection on ZIKV outcome remains unclear. To study this potential impact, we analyzed large 2016 epidemic Managua, Nicaragua, a pediatric cohort with well-characterized histories.Symptomatic infections (Zika cases) were identified by real-time reverse transcription PCR serology community-based follows approximately...
COVID-19 vaccines have recently been updated to specifically encode or contain the spike protein of SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet be fully evaluated and reported, particularly against emergent viruses that are rapidly expanding. We now report administration an monovalent mRNA vaccine booster (XBB.1.5 MV) previously uninfected individuals boosted serum virus-neutralizing antibodies significantly not only (27.0-fold increase) EG.5.1 (27.6-fold also...
To combat the evolving SARS-CoV-2 Omicron variants, bivalent COVID-19 mRNA vaccines, encoding both ancestral and BA.5 spikes, have replaced monovalent vaccines in numerous countries. However, fourth doses of either vaccine result similar neutralizing antibody titers against subvariants, raising possibility immunological imprinting. address this, we investigate responses 72 participants given three a vaccine, followed by or booster, those with breakthrough infections BQ. Bivalent boosters do...
Summary COVID-19 vaccines have recently been updated with the spike protein of SARS-CoV-2 XBB.1.5 subvariant alone, but their immunogenicity in humans has yet to be fully evaluated and reported, particularly against emergent viruses that are rapidly expanding. We now report administration an monovalent mRNA vaccine (XBB.1.5 MV) uninfected individuals boosted serum virus-neutralization antibodies significantly not only (27.0-fold) currently dominant EG.5.1 (27.6-fold) also key like HV.1,...
Infection with any of the four dengue virus serotypes (DENV1-4) can protect against or enhance subsequent depending on preexisting antibodies and infecting serotype. Additionally, primary infection related flavivirus Zika (ZIKV) is associated increased risk DENV2 disease. Here, we measured how prior DENV ZIKV immunity influenced disease caused by DENV1-4 in a pediatric Nicaraguan cohort. Of 3412 participants 2022, 10.6% experienced cases DENV1 (