A5100714641- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Hepatitis C virus research
- Cardiac Imaging and Diagnostics
- Malaria Research and Control
- Cardiac Arrhythmias and Treatments
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Heart Failure Treatment and Management
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Cardiomyopathy and Myosin Studies
- Clostridium difficile and Clostridium perfringens research
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Antimicrobial Resistance in Staphylococcus
- Liver Disease Diagnosis and Treatment
- Escherichia coli research studies
- HIV/AIDS Research and Interventions
- Antibiotics Pharmacokinetics and Efficacy
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
The University of Tokyo
1975-2025
University of Oxford
2018-2025
Infectious Diseases Data Observatory
2020-2025
Angkor Hospital for Children
2025
University of Tokyo Hospital
1966-2024
Tokyo University of Science
1975-2024
Southern Tohoku General Hospital
2023-2024
Mahidol Oxford Tropical Medicine Research Unit
2018-2024
Shoklo Malaria Research Unit
2018-2024
Mahidol University
2018-2024
Reverse transcription-quantitative PCR (RT-qPCR)-based tests are widely used to diagnose coronavirus disease 2019 (COVID-19). As a result that these cannot be done in local clinics where RT-qPCR testing capability is lacking, rapid antigen (RATs) for COVID-19 based on lateral flow immunoassays diagnosis. However, their sensitivity compared with each other and infectious virus isolation has not been examined. Here, we the among four RATs by using severe acute respiratory syndrome 2...
BackgroundTo develop an effective vaccine against a novel viral pathogen, it is important to understand the longitudinal antibody responses its first infection. Here we performed study of SARS-CoV-2 in symptomatic patients.MethodsSequential blood samples were collected from 39 individuals at various timepoints between 0 and 154 days after onset. IgG or IgM titers receptor binding domain (RBD) S protein, ectodomain N protein determined by using ELISA. Neutralizing measured plaque reduction...
Late gadolinium enhancement (LGE) on contrast-enhanced magnetic resonance imaging (MRI) in hypertrophic cardiomyopathy (HCM) has been reported to be associated with myocardial fibrosis and cardiac events. In patients HCM, two-dimensional (2D) strain can identify subclinical global systolic dysfunction despite normal left ventricular (LV) chamber function. Therefore, this study tested the hypothesis that 2D could detect subtle serve as a novel prognostic parameter HCM...
Significance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are of concern, with the P.1 dominating in Brazil. Brazil is now seeing a record number deaths. Here, we report that pathogenicity hamsters variant similar to nonvariant SARS-CoV-2. However, it has an expanded host range as shown by its replication mice. Prior infection SARS-CoV-2 strains efficiently prevented lower tract upon reinfection. Convalescent sera from patients infected nonvariants or messenger RNA...
Limited knowledge exists on immune markers associated with disease severity or recovery in patients coronavirus 2019 (COVID-19). Here, we elucidated longitudinal evolution of SARS-CoV-2 antibody repertoire acute COVID-19. Differential kinetics was observed for immunoglobulin M (IgM)/IgG/IgA epitope diversity, binding, and affinity maturation "severe" versus "mild" COVID-19 patients. IgG profile demonstrated immunodominant antigenic sequences encompassing fusion peptide receptor binding...
The role of the intestinal microbiota in coronavirus disease 2019 (COVID-19) is being elucidated. Here, we analyzed temporal changes composition and correlation between inflammation biomarkers/cytokines hospitalized COVID-19 patients. We obtained stool specimens, blood samples, patient records from 22 patients performed 16S rRNA metagenomic analysis samples over course onset compared to 40 healthy individual samples. gut plasma proinflammatory cytokine levels. Immediately after admission,...
Abstract Denosumab and romosozumab, a recently approved new drug, are effective widely known molecular-targeted drugs for postmenopausal osteoporosis treatment. However, no studies have directly compared their therapeutic effects or safety in osteoporosis. This retrospective observational registry study the efficacy of 12-month denosumab romosozumab treatment patients. The primary outcome was change bone mineral density (BMD) at lumbar spine. Secondary outcomes included BMD changes total hip...
Antioxidants such as vitamins C and E have been reported to inhibit the progression of ultraviolet (UV) radiation-induced pigmentation in skin hairless mice. However, little is known lightening effect proanthocyanidin, a powerful polyphenolic antioxidant, on UV-induced skin. We investigated oral administration proanthocyanidin-rich grape seed extract (GSE) using guinea pigs with pigmentation. These pigmented were fed diets containing 1% GSE or vitamin (w/w) for 8 weeks. GSE-feeding had an...
The anti-allergic activity of a tomato extract was studied by using an in vitro histamine-release assay. skin exerted the strongest inhibition histamine release. Chlorogenic acid, rutin and naringenin were identified 60% ethanol skin. However, contained unknown compound which strongly inhibited This active as chalcone (trans-2'4'6'4-tetrahydroxychalcone). Naringenin release with IC(50) value 68 microg/ml. next investigated vivo mouse ear-swelling response. We found that showed inhibitory...
Following consecutive 12-wk administration of tablets containing 0, 200 or 400 mg grape seed extract (calculated as proanthocyanidin) to 61 healthy subjects with LDL cholesterol (LDL-C) levels 100 180 mg/dL, effects such treatment compared placebo on malondialdehyde-modified (MDA-LDL), representing one oxidized type LDL, were investigated by a single blind method. MDA-LDL level in the group was significantly (p=0.008) reduced basal level, 12 wk after start administration. In group,...
Enteropathogenic Escherichia coli isolated from diarrheal children and adults were studied. Twenty-two OK groups set up as enteropathogenic Eschericha to include: O26: K60, O28a, 28c : K73, O44: K74, O55: K59, O86: K61, K62, O111: K58, O112a, 112c K66, 0119: K69, O124: K72, O125: K70, O126: K71, O127: K63, O128: K67, O136: K78, O143: Kx1, O144: Kx2, O146: K87, A-D (Alkalescens-Dispar) O1: K1, O2: O3: K2, 04: K3.1. Seven hundred eighty-nine strains of the collected adults. group K72 greatly...