Noriko Nakajima
A5101504047- Influenza Virus Research Studies
- Respiratory viral infections research
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- HIV Research and Treatment
- Eosinophilic Esophagitis
- Sepsis Diagnosis and Treatment
- Viral Infections and Vectors
- Lung Cancer Treatments and Mutations
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Whipple's Disease and Interleukins
- Radiomics and Machine Learning in Medical Imaging
- Clinical Nutrition and Gastroenterology
- Esophageal and GI Pathology
- SARS-CoV-2 detection and testing
National Institute of Infectious Diseases
2015-2024
The University of Tokyo
1998-2024
National Center for Global Health and Medicine
2020-2023
University of Wisconsin–Madison
2017-2023
Tokyo University of Science
2023
Kyoto University Hospital
2018-2022
Toyooka Hospital
2022
Fujita Health University
2021
Nihon University
2007-2020
Tokyo Metropolitan Institute of Public Health
2020
Significance Since SARS-CoV-2 emerged in China, it has spread rapidly around the world. Effective vaccines and therapeutics for SARS-CoV-2−induced disease (coronavirus 2019;COVID-19) are urgently needed. We found that isolates replicate efficiently lungs of Syrian hamsters cause severe pathological lesions these animals similar to commonly reported imaging features COVID-19 patients with pneumonia. SARS-CoV-2−infected mounted neutralizing antibody responses were protected against rechallenge...
The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral pathogenesis and transmissibility remain unclear. We engineered a SARS-CoV-2 variant containing this substitution. exhibits more efficient infection, replication, competitive fitness primary human airway epithelial cells maintains similar morphology vitro neutralization properties, compared with the ancestral...
Background. Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. This article describes the first identified patient retrospective study on Japan.
The recent emergence of B.1.1.529, the Omicron variant
Abstract An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome 2 antigen epithelial cells and macrophages. Coronavirus is essentially lower tract characterized by direct viral injury cells.
In parallel with vaccination, oral antiviral agents are highly anticipated to act as countermeasures for the treatment of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Oral medication demands not only high activity but also target specificity, favorable bioavailability, and metabolic stability. Although a large number compounds have been identified potential inhibitors SARS-CoV-2 infection in vitro, few proven be effective vivo....
Abstract Context.—An outbreak of severe acute respiratory syndrome (SARS), an infectious disease attributed to a novel coronavirus, occurred in Singapore during the first quarter 2003 and led 204 patients with diagnosed illnesses 26 deaths by May 2, 2003. Twenty-one percent these required admission medical intensive care unit. During this period, Center for Forensic Medicine, Health Sciences Authority, Singapore, performed total 14 postmortem examinations probable suspected SARS. Of these, 8...
Abstract Context.—An outbreak of severe acute respiratory syndrome (SARS), an infectious disease attributed to a novel coronavirus, occurred in Singapore during the first quarter 2003 and led 204 patients with diagnosed illnesses 26 deaths by May 2, 2003. Twenty-one percent these required admission medical intensive care unit. During this period, Center for Forensic Medicine, Health Sciences Authority, Singapore, performed total 14 postmortem examinations probable suspected SARS. Of these, 8...
<h3>Background and aims:</h3> The effect of adiponectin on colorectal carcinogenesis has been proposed but not fully investigated. We investigated the deficiency development cancer. <h3>Methods:</h3> generated three types gene-deficient mice (adiponectin-deficient, receptor 1-deficient, 2-deficient) chemical-induced colon polyp formation cell proliferation in epithelium. Western blot analysis was performed to elucidate mechanism which affected by deficiency. <h3>Results:</h3> numbers polyps...
Metformin is a biguanide derivative that widely used in the treatment of diabetes mellitus. One pharmacological targets metformin adenosine monophosphate-activated protein kinase (AMPK). We investigated effect on suppression intestinal polyp formation ApcMin/+ mice. Administration (250 mg/kg) did not reduce total number formations, but significantly reduced formations larger than 2 mm diameter To examine indirect metformin, index insulin resistance and serum lipid levels mice were assessed....
ABSTRACT Proteolytic cleavage of the hemagglutinin (HA) protein is essential for influenza A virus (IAV) to acquire infectivity. This process mediated by a host cell protease(s) in vivo . The type II transmembrane serine protease TMPRSS2 expressed respiratory tract and capable activating variety viruses, including low-pathogenic (LP) IAVs possessing single arginine residue at site. Here we show that plays an role proteolytic activation LP IAVs, recently emerged H7N9 subtype, We generated...
<h3>Background and aims</h3> Obesity increases the risk of colorectal cancer (CRC). Serum leptin levels are markedly elevated in obese individuals, but involvement CRC growth remains unclear. We explored hypothesis that signalling regulates CRC, by examining effects deficiency on murine colon tumour growth. <h3>Methods</h3> used genetic (leptin-deficient receptor-deficient) models obesity investigated carcinogen-induced polyp formation cell proliferation colonic epithelium. Colonic tissues...
Abstract Despite the development and deployment of antibody vaccine countermeasures, rapidly-spreading SARS-CoV-2 variants with mutations at key antigenic sites in spike protein jeopardize their efficacy. The recent emergence B.1.1.529, Omicron variant1,2, which has more than 30 protein, raised concerns for escape from protection by vaccines therapeutic antibodies. A test potential countermeasures against B.1.1.529 is activity pre-clinical rodent models respiratory tract disease. Here, using...
Significance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are of concern, with the P.1 dominating in Brazil. Brazil is now seeing a record number deaths. Here, we report that pathogenicity hamsters variant similar to nonvariant SARS-CoV-2. However, it has an expanded host range as shown by its replication mice. Prior infection SARS-CoV-2 strains efficiently prevented lower tract upon reinfection. Convalescent sera from patients infected nonvariants or messenger RNA...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic caused by a tick-borne banyangvirus and associated high fatality. Despite increasing incidence of SFTS serious public health concerns in East Asia, the pathogenesis lethal virus (SFTSV) infection humans not fully understood. Numbers postmortem examinations to determine target cells viral have so far been limited. Here we showed that B differentiating into plasmablasts macrophages secondary lymphoid organs were...
Pandemic 2009 influenza A virus (A/H1N1/2009) has emerged globally. In this study, we performed a comprehensive detection of potential pathogens by de novo sequencing using next-generation DNA sequencer on total RNAs extracted from an autopsy lung patient who died viral pneumonia with A/H1N1/2009. Among 9.4×106 40-mer short reads, more than 98% appeared to be human, while 0.85% were identified as A/H1N1/2009 (A/Nagano/RC1-L/2009(H1N1)). Suspected bacterial reads such Streptococcus pneumoniae...
ABSTRACT Ferrets and mice are frequently used as animal models for influenza research. However, ferrets demanding in terms of housing space handling, whereas not naturally susceptible to infection with human A or B viruses. Therefore, prior adaptation viruses is required their use mice. In addition, there no mouse-adapted variants the recent H3N2 viruses, because these do replicate well this study, we investigated susceptibility Syrian hamsters a view using hamster model an alternative mouse...
Abstract The D614G substitution in the S protein is most prevalent SARS-CoV-2 strain circulating globally, but its effects viral pathogenesis and transmission remain unclear. We engineered variants harboring with or without nanoluciferase. variant replicates more efficiency primary human proximal airway epithelial cells fit than wildtype (WT) virus competition studies. With similar morphology to WT virion, also sensitive neutralizing antibodies. Infection of ACE2 transgenic mice Syrian...