Ana S. González-Reiche
A5062180261- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Long-Term Effects of COVID-19
- COVID-19 epidemiological studies
- Bacillus and Francisella bacterial research
- Craniofacial Disorders and Treatments
- Poxvirus research and outbreaks
- Biosensors and Analytical Detection
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- interferon and immune responses
- Herpesvirus Infections and Treatments
- dental development and anomalies
- Viral Infections and Outbreaks Research
- vaccines and immunoinformatics approaches
- Congenital heart defects research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
Icahn School of Medicine at Mount Sinai
2018-2025
Universidad del Valle de Guatemala
2010-2022
City University of Seattle
2022
New York Proton Center
2021
Mount Sinai Health System
2021
University of Georgia
2016-2018
University of London
2018
Universidad de Salamanca
2018
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018
La Trobe University
2018
The recent emergence of B.1.1.529, the Omicron variant
Blighted Gotham Deaths caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in New York City (NYC) during the spring of 2020 have vastly exceeded those reported China and many other countries. What were early events that led to such a outbreak? Gonzalez-Reiche et al. sampled some patients seeking assistance February March at Mount Sinai Health System. Phylogenetic analysis virus sequences these people, who drawn from across NYC, showed had been independently introduced...
We report the spillover of highly pathogenic avian influenza A(H5N1) into marine mammals in northeastern United States, coincident with H5N1 sympatric wild birds. Our data indicate monitoring both coastal birds and will be critical to determine pandemic potential A viruses.
Despite great efforts put forward worldwide to combat the current coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome 2 (SARS-CoV-2) continues be a human health and socioeconomic threat. Insights into pathogenesis of SARS-CoV-2 contribution viral proteins outcome remain elusive.
Abstract Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been reported in immune-compromised individuals and people undergoing immune-modulatory treatments. Although intrahost evolution has documented, direct evidence of subsequent transmission continued stepwise adaptation is lacking. Here we describe sequential persistent SARS-CoV-2 three that led to the emergence, forward transmission, a new Omicron sublineage, BA.1.23, over an eight-month period....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins that inhibit host interferon responses. Among these, ORF6 antagonizes signaling by disrupting nucleocytoplasmic trafficking through interactions with the nuclear pore complex components Nup98-Rae1. However, roles and contributions of during physiological infection remain unexplored. We assessed role using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. plays key...
BackgroundThe efficacy of public health measures to control the transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not been well studied in young adults.MethodsWe investigated SARS-CoV-2 infections among U.S. Marine Corps recruits who underwent a 2-week quarantine at home followed by second supervised closed college campus that involved mask wearing, social distancing, and daily temperature symptom monitoring. Study volunteers were tested for means quantitative...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in domestic and wild cats. However, little is known about natural viral infections of cats, although their importance for modelling disease spread, informing strategies managing positive human-animal relationships prevention. Here, we describe the SARS-CoV-2 infection a household two human adults sibling cats (one male females) using real-time RT–PCR, an ELISA test, sequencing, virus isolation. On May 5th, 2020,...
Abstract Despite the development and deployment of antibody vaccine countermeasures, rapidly-spreading SARS-CoV-2 variants with mutations at key antigenic sites in spike protein jeopardize their efficacy. The recent emergence B.1.1.529, Omicron variant1,2, which has more than 30 protein, raised concerns for escape from protection by vaccines therapeutic antibodies. A test potential countermeasures against B.1.1.529 is activity pre-clinical rodent models respiratory tract disease. Here, using...
Gastrointestinal symptoms are common in COVID-19 patients but the nature of gut immune response to SARS-CoV-2 remains poorly characterized, partly due difficulty obtaining biopsy specimens from infected individuals. In lieu tissue samples, we measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses stool samples a cohort 44 hospitalized patients. RNA was detected 41% more frequently with diarrhea. Patients who survived had lower fecal than those...
Monkeypox virus (MPXV) is a zoonotic orthopoxvirus within the Poxviridae family. MPXV endemic to Central and West Africa. However, world currently witnessing an international outbreak with no clear epidemiological links travel or animal exposure ever-increasing numbers of reported cases worldwide. Here, we evaluated validated new, sensitive, specific real-time PCR-assay for diagnosis in humans compare performance this novel assay against Food & Drug Administration-cleared pan-Orthopox RT-PCR...
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1–3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling >15,000 longitudinal blood nasal samples 540 participants the using 14 distinct assays. These unbiased analyses identify cellular molecular signatures present within 72 h hospital admission that...
Highly pathogenic H5N1 avian influenza viruses (HPAIV) belonging to lineage 2.3.4.4b emerged in Chile December 2022, leading mass mortality events wild birds, poultry, and marine mammals one human case. We detected HPAIV 7,33% (714/9745) of cases between 2022-April 2023 sequenced 177 virus genomes from mammals, a human, birds spanning >3800 km Chilean coastline. were closely related Peru's outbreak, consistent with north-to-south spread down the Pacific One nine mammal had rare PB2 D701N...
ABSTRACT New York City (NYC) has emerged as one of the epicenters current SARS-CoV2 pandemic. To identify early events underlying rapid spread virus in NYC metropolitan area, we sequenced causing COVID19 patients seeking care at Mount Sinai Health System. Phylogenetic analysis 84 distinct genomes indicates multiple, independent but isolated introductions mainly from Europe and other parts United States. Moreover, find evidence for community transmission suggested by clusters related viruses...
Craniofacial abnormalities often involve sutures, the growth centers of skull. To characterize organization and processes governing their development, we profile murine frontal suture, a model for sutural fusion, at tissue- single-cell level on embryonic days (E)16.5 E18.5. For wild-type bulk RNA sequencing (RNA-seq) analysis identifies mesenchyme-, osteogenic front-, stage-enriched genes biological processes, as well alternative splicing events modifying extracellular matrix. Single-cell...
BackgroundHighly efficacious vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed. However, the emergence of viral variants that are more infectious than earlier SARS-CoV-2 strains is concerning. Several these potential to partially escape neutralizing antibody responses, warranting continued immune-monitoring.MethodsWe used a panel 30 post-mRNA vaccination sera determine neutralization and RBD spike binding activity number emerging variants. The...
Abstract The recent incursion of Highly Pathogenic Avian Influenza A (H5N1) virus into North America and subsequent dissemination across the continent, has had significant adverse impacts on domestic poultry, led to widespread mortality in many wild bird species. Here we report spillover H5N1 marine mammals northeastern United States, with associated a regional scale. This is coincident second wave sympatric birds also experiencing events. Viral sequences derived from both seal avian hosts...