A5041911776- Immune Cell Function and Interaction
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- Down syndrome and intellectual disability research
- IL-33, ST2, and ILC Pathways
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Silicon Carbide Semiconductor Technologies
- Pediatric health and respiratory diseases
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Immune responses and vaccinations
- Hepatitis B Virus Studies
- Nanowire Synthesis and Applications
- Lung Cancer Research Studies
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
Benaroya Research Institute
2019-2025
Virginia Mason Medical Center
2022-2025
University of Washington
2025
Texas Children's Hospital
2024
Baylor College of Medicine
2024
Advanced Cell Technology (United States)
2023
Permutational analysis of the immune system reveals advanced aging in individuals with Down syndrome and type 1 diabetes.
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1–3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling >15,000 longitudinal blood nasal samples 540 participants the using 14 distinct assays. These unbiased analyses identify cellular molecular signatures present within 72 h hospital admission that...
<title>Abstract</title> Interleukin-15 (IL15) promotes the survival of T lymphocytes and enhances antitumor properties CAR cells in preclinical models solid neoplasms which have limited efficacy1-4. Glypican-3 (GPC3) is expressed a group cancers5-10, here we report first evaluation humans effects IL15 co-expression on GPC3-CAR cells. Cohort 1 patients (NCT02905188/NCT02932956) received cells, were safe but produced no objective responses reached peak expansion at two weeks. 2...
Maintenance of immune homeostasis involves a synergistic relationship between the host and microbiome. Canonical interferon (IFN) signaling controls responses to acute microbial infection, through engagement STAT1 transcription factor. However, contribution tonic levels IFN in absence infection remains largely unexplored. We report that KO mice spontaneously developed an inflammatory disease marked by myeloid hyperplasia splenic accumulation hematopoietic stem cells. Moreover, these animals...
Abstract Dysregulated differentiation of naïve CD4+ T cells into helper 17 (Th17) is likely a key factor predisposing to many autoimmune diseases. Therefore, better understanding how Th17 regulated essential identify novel therapeutic targets and strategies individuals at high risk developing autoimmunity. Here, we extend our prior work using chemical inhibitors provide mechanistic insight regulator differentiation, the kinase dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A)....
Immune health requires innate and adaptive immune cells to engage precisely balanced pro- anti-inflammatory forces. We employ the concept of chemical immunophenotypes classify small molecules functionally or mechanistically according their patterns effects on primary cells. The high-specificity, low-toxicity cyclin-dependent kinase 8 (CDK8) inhibitor 16-didehydro-cortistatin A (DCA) exerts a distinct tolerogenic profile in both DCA promotes regulatory T (T
ABSTRACT Importance Hepatocellular carcinoma accounts for approximately 80% of liver neoplasms. Globally, hepatocellular ranks as the third most lethal cancer, with number deaths expected to further increase by 2040. In adults, disparities in incidence and survival are well described while pediatric epidemiology is not characterized. Objective To describe (ages 0-19 years) cases compare these measures adults ≥20 diagnosed carcinoma. We evaluated demographic factors clinical characteristics...
Abstract Immune health requires innate and adaptive immune cells to engage precisely balanced pro- anti-inflammatory forces. We employ the concept of chemical immunophenotypes classify small molecules functionally or mechanistically according their patterns effects on primary cells. The high-specificity, low-toxicity cyclin dependent kinase 8 (CDK8) inhibitor DCA exerts a distinct tolerogenic profile in both promotes T reg Th2 differentiation, while inhibiting Th1 Th17 murine human This...
Abstract Maintenance of immune homeostasis involves a synergistic relationship between the host and microbiome. Canonical interferon (IFN) signaling controls responses to acute microbial infection, through engagement STAT1 transcription factor. However, contribution tonic levels IFN in absence infection remains largely unexplored. We report that KO mice spontaneously developed an inflammatory disease marked by myeloid hyperplasia splenic accumulation hematopoietic stem cells. Moreover, these...
Abstract People with Down syndrome show cellular and clinical features of dysregulated aging the immune system, including naïve-memory shift in T cell compartment increased incidence autoimmunity. However, a quantitative understanding how various compartments change age remains lacking. Here we performed deep immunophenotyping cohort individuals across lifespan, selecting for not affected by We simultaneously interrogated age- sex-matched healthy neurotypical controls people type 1 diabetes,...