A5060277824- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Formal Methods in Verification
- Advanced Authentication Protocols Security
- User Authentication and Security Systems
- Information and Cyber Security
- Model-Driven Software Engineering Techniques
- Embedded Systems Design Techniques
- Animal Virus Infections Studies
- Cryptographic Implementations and Security
- Security and Verification in Computing
- Advanced Malware Detection Techniques
- SARS-CoV-2 detection and testing
- Software Reliability and Analysis Research
- Network Security and Intrusion Detection
- Gestational Diabetes Research and Management
- VLSI and Analog Circuit Testing
- Access Control and Trust
- Logic, programming, and type systems
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Viral gastroenteritis research and epidemiology
- Business Process Modeling and Analysis
- Logic, Reasoning, and Knowledge
- Real-time simulation and control systems
Icahn School of Medicine at Mount Sinai
2023-2025
Czech Academy of Sciences, Institute of Microbiology
2023
Coalition for Epidemic Preparedness Innovations
2023
University of Massachusetts Amherst
2021
University College London
2011
Hewlett-Packard (United States)
2002-2010
Hewlett-Packard (United Kingdom)
2005
Bristol Laboratories (United Kingdom)
2005
University of Manchester
1991-2002
Manchester University
2002
Abstract Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been reported in immune-compromised individuals and people undergoing immune-modulatory treatments. Although intrahost evolution has documented, direct evidence of subsequent transmission continued stepwise adaptation is lacking. Here we describe sequential persistent SARS-CoV-2 three that led to the emergence, forward transmission, a new Omicron sublineage, BA.1.23, over an eight-month period....
It is thought that mRNA-based vaccine-induced immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wanes quickly, based mostly on short-term studies. Here, we analyzed the kinetics and durability of humoral responses SARS-CoV-2 infection vaccination using >8,000 longitudinal samples collected over a 3-year period in New York City. Upon primary immunization, participants with pre-existing mounted higher antibody faster achieved steady-state titers than naive individuals....
Abstract Sero-monitoring provides context to the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and changes in population immunity following vaccine introduction. Here, we describe results a cross-sectional hospital-based study anti-spike seroprevalence New York City (NYC) from February 2020 July 2022, follow-up period August 2023 October 2023. Samples 55,092 individuals, spanning five epidemiological waves were analyzed. Prevalence ratios (PR)...
Subvariants of the Omicron lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) efficiently escape neutralizing antibody responses induced by both vaccination and infection with antigenically distinct variants. Here, we describe potency breadth binding against a large panel variants following an BA.1 or BA.2 breakthrough in heterogeneous cohort individuals diverse exposure histories. Both infections significantly boost levels broaden reactivity. However, this broader immunity...
Antibodies on mucosal surfaces of the upper respiratory tract have been shown to be important for protection from infection with SARS-CoV-2. Here we investigate induction serum IgG, saliva and sIgA after COVID-19 mRNA booster vaccination or breakthrough infections.
The rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants has emphasized need to identify antibodies with broad neutralizing capabilities inform future monoclonal therapies and vaccination strategies. Herein, we identified S728-1157, a broadly antibody (bnAb) targeting receptor-binding site (RBS) that was derived from an individual previously infected WT SARS-CoV-2 prior spread concern (VOCs). S728-1157 demonstrated cross-neutralization all...
As demonstrated by severe acute respiratory syndrome coronavirus 2, coronaviruses pose a significant pandemic threat. Here, we show that disease 2019 mRNA vaccination can induce levels of cross-reactive antibodies against diverse spike proteins. While these are binding likely have little neutralization capacity and while their contribution to cross-protection is unclear, it possible they may play role in protection from progression with novel coronaviruses.
The evolution of the antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is impacted by nature and number antigenic exposures. First-generation disease 2019 (COVID-19) vaccines encoded an ancestral spike protein. Updated bivalent breakthrough infections have shaped intricate diversity polyclonal specificity individual clones. We others previously showed that containing Omicron (BA.5) spikes induce high levels cross-reactive antibodies but undetectable...
Journal Article A Logical and Computational Theory of Located Resource Get access Matthew Collinson, Collinson HP Labs, Long Down Avenue, Stoke Gifford, Bristol BS34 8QZ, England, UK.E-mail: collinson@hp.com; brian.monahan@hp.com Search for other works by this author on: Oxford Academic Google Scholar Brian Monahan, Monahan David Pym UK; University Bath, BA2 7AY, david.pym@hp.com Logic Computation, Volume 19, Issue 6, December 2009, Pages 1207–1244, https://doi.org/10.1093/logcom/exp021...
Simulation modelling is an important tool for exploring and reasoning about complex systems. Many supporting languages are available. Commonly occurring features of these constructs capturing concepts such as process, resource, location. We describe a mathematical framework that su
The real-world impact of bivalent vaccines for wild type (WA.1) and Omicron variant (BA.5) is largely unknown in immunocompromised patients with Multiple Myeloma (MM). We characterize the humoral cellular immune responses MM before after receiving booster, including neutralizing assays to identify patterns associated continuing vulnerability current variants (XBB1.16, EG5) post-pandemic era.
Abstract The objective of this study was to determine the association between birthweight and risk thyroid autoimmune conditions in a large sample postmenopausal women. Baseline data from Women’s Health Initiative (n = 80,806) were used examine associations category (<6 lbs., 6–7 lbs. 15 oz, 8–9 ≥10 lbs.) prevalent (underactive overactive goiter) (lupus, rheumatoid arthritis (RA), multiple sclerosis, ulcerative colitis/Crohn’s disease) conditions. Follow-up questionnaire incident...
Preterm birth has been associated with insulin resistance and beta-cell dysfunction, a hallmark characteristic of type 2 diabetes. However, studies investigating the relationship between personal history being born preterm diabetes are sparse. We sought to investigate potential association risk for in racially ethnically diverse population. Baseline incident data (>16 years follow-up) from Women's Health Initiative (n = 85,356) were used examine (born 1910-1940s) prevalent (baseline...