A5002957631- Vector-borne infectious diseases
- Virus-based gene therapy research
- Viral Infections and Vectors
- Cancer-related Molecular Pathways
- Veterinary Oncology Research
- Vector-Borne Animal Diseases
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- T-cell and B-cell Immunology
- Animal Virus Infections Studies
- Hedgehog Signaling Pathway Studies
- Cell Adhesion Molecules Research
- Rabies epidemiology and control
- Animal Genetics and Reproduction
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Toxin Mechanisms and Immunotoxins
- Telomeres, Telomerase, and Senescence
- Insect and Pesticide Research
- Leptospirosis research and findings
- Immunodeficiency and Autoimmune Disorders
- Oral and Maxillofacial Pathology
Yamaguchi University
2015-2024
Osaka University Hospital
2024
The University of Tokyo
1993-2024
Tsuda University
2017
Hiroshima University
2010-2012
Institut de Neurobiologie de la Méditerranée
2002-2005
Sciences pour L’Œnologie
2005
Zenyaku Kogyo (Japan)
2001
Ministry of Education, Culture, Sports, Science and Technology
2001
Nihon University
1980-2001
Background. Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. This article describes the first identified patient retrospective study on Japan.
The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed the caninized anti-canine PD-1 (ca-4F12-E6) and evaluated its therapeutic properties dogs with advance-staged oral malignant melanoma (OMM), however, their effects on other types canine tumors remain unclear.
ABSTRACT Babesia and Hepatozoon infections of dogs in a village eastern Sudan were analyzed by using single PCR sequencing. Among 78 dogs, 5 infected with canis rossi 2 others B. vogeli . Thirty-three positive for Hepatozoon. was detected sequence analysis.
ABSTRACT Detection and analysis of Babesia species from ticks recovered dogs in Japan were attempted by PCR nucleotide sequence based on the 18S rRNA gene, respectively. A total 1,136 examined for DNA rRNA-based sequencing. Partial sequences canis vogeli detected six Aomori, Nara, Hiroshima, Oita, Okinawa Prefectures; gibsoni Asia-1 was also four Osaka, Miyazaki, Prefectures. Unique 1,678 bp obtained Ixodes ovatus Akita Fukui The similar to those odocoilei (97.7%) divergens (97.6%). This is...
The concentration of feline serum amyloid A (fSAA) was determined by a direct enzyme-linked immunosorbent assay (ELISA) using fSAA specific monoclonal antibodies, to evaluate the as an inflammatory marker in cats. mean ± standard deviation found be 0.60 1.06 μg/m l and 33.65 67.59 μg/ml samples from normal cats (n=45) (n=312) with various diseases disorders, respectively. significant difference (p<0.001) between two groups. It also that begins increase rapidly at approximately 3-6 hr after...
Abstract. The species of ixodid ticks (Acari: Ixodidae) recovered from domestic dogs in Japan between September to November 2000 and April June 2001 were identified. A total 4122 ticks, including 1624 larvae, 1200 nymphs, 1016 females 282 males removed 1221 during these periods. Haemaphysalis longicornis (Neumann) was the most frequently found (40.3% dogs), followed by H. flava (16.1% Rhipicephalus sanguineus (Latreille) (4.8% dogs) Ixodes ovatus (4.1% dogs). Small numbers hystricis...
Abstract Objective —To evaluate aberrations of the p53 tumor suppressor gene in naturally developing tumors dogs. Sample Population —Tumor specimens from 15 dogs with various tumors, including malignant lymphoma (7 dogs), monocytic leukemia (1), mammary gland adenoma benign mixed rhabdomyosarcoma colon cancer and osteosarcoma (3). Procedure —Aberrations these tissues were examined by reverse transcriptase- polymerase chain reaction single-strand conformation polymorphism analysis, using 3...
Abstract Purpose: Recent studies have reported that centrosome hyperamplification (CH) is closely related to chromosomal instability in bladder cancer. In this study, we investigated whether CH could be used as a prognostic biomarker for patients with Experimental Design: was evaluated by immunohistochemistry 50 cancers (≤pT1: 43; ≥pT2: 7). addition, numerical aberrations of chromosomes 7, 9, and 17 gain 20q13, on which the Aurora-A gene located, were fluorescence situ hybridization, DNA...
To investigate the bioactivities of fresh garlic and its processed product, black garlic, we conducted comparative analyses antioxidant, anti-inflammatory, innate immune activation, anti-cancer activities in addition to chemical composition (sugar, amino acid, polyphenol contents) these materials. Simultaneous assay using neutrophil-like cells showed that exhibited antioxidant immunostimulatory activities, whereas displayed a potent anti-inflammatory effect. The activity index was correlated...
To determine the distribution of Babesia gibsoni infection in dogs eastern part Japan, an epidemiological survey suspected having B. was attempted using polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA). Thirty-five 115 such (30.4%) were positive by PCR and/or ELISA. The 35 consisted 28 Tosa dogs, 4 American Pit Bull Terriers, 3 mongrel Aomori, Fukushima, Ibaraki, Gunma, Chiba, Tokyo, Kanagawa, Nagano Prefectures. had a significantly lower rate tick exposure...
Elimination of the regulatory mechanism underlying numeral homeostasis centrosomes, as seen in cells lacking p53, results abnormal amplification which increases frequency chromosome segregation errors, and thus contributes to instability frequently observed cancer cells. We have previously reported that p53(-/-) mouse prolonged culture undergo genomic convergence similar during tumor progression; early-passage are karyotypically heterogeneous due extensive associated with centrosome...
ABSTRACT Canine DNA samples from South Africa were found to contain 16S rRNA gene nucleotide and citrate synthase deduced amino acid sequences that most similar Anaplasma phagocytophilum : 98%, 66%, 69% similarity, respectively. This suggests a new species closely related A. occurs in Africa.
The importance of CD4+CD25+Foxp3 + regulatory T cells (Treg cells) in immune response is increasingly being recognized. However, to date, only a few studies on these have been conducted canine species, partly because the unavailability appropriate antibodies detect this cell population. In study, crossreactivities anti-human CD25 antibody (clone ACT-1) and anti-mouse Foxp3 FJK16s) Foxp3, respectively, were confirmed using lines overexpressing either genes. By antibodies, we determined if...
ABSTRACT The 1,670-bp nucleotide sequence of the heat shock operon groESL and 1,236-bp citrate synthase gene ( gltA ) Anaplasma Ehrlichia platys were determined. topology groEL - -based phylogenetic tree was similar to that derived from 16S rRNA analyses with distances. Both PCRs specific A. also developed based upon alignment data.