A5024477800- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Parasitic Diseases Research and Treatment
- Fractal and DNA sequence analysis
- Lysosomal Storage Disorders Research
- Vector-Borne Animal Diseases
- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Bacteriophages and microbial interactions
- Calcium signaling and nucleotide metabolism
- Evolution and Genetic Dynamics
- Child Nutrition and Water Access
- Cytomegalovirus and herpesvirus research
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Eosinophilic Disorders and Syndromes
- Genomics and Rare Diseases
- Parasite Biology and Host Interactions
- Leptospirosis research and findings
Institut de Recherche pour le Développement
2016-2025
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2016-2025
Université de Montpellier
2018-2025
Interactions hotes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides
2008-2024
Biologie et Génétique des Interactions Plante-Parasite
2013-2024
Institut de Recherche Agronomique de Guinée
2014-2023
Ministère de la Santé
2023
Pan African Tsetse and Trypanosomiasis Eradication Campaign
2019-2020
Inserm
2000-2017
Aix-Marseille Université
2009-2017
H3Africa is developing capacity for health-related genomics research in Africa
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have regarded primarily blood-dwelling organisms. Intriguingly, infections with low or undetected blood are common, particularly the case Human African Trypanosomiasis caused by Trypanosoma brucei gambiense. We hypothesise, therefore, represents an anatomic reservoir infection. Here we definitively show that substantial quantities trypanosomes exist...
IL-17 and IL-22 have been shown to increase protection against certain bacteria fungal pathogens in experimental models. However, no human studies demonstrated a crucial role of infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates differentiation Th17 cells, produce IL-17, IL-22, IFN-gamma. Analysis Th1, Th2, cytokine responses by cultured PBMCs from individuals cohort subjects who developed KA or were protected during...
The final outcome of infection by Trypanosoma brucei gambiense, the main agent sleeping sickness, has always been considered as invariably fatal. While scarce and old reports have mentioned cases self-cure in untreated patients, these studies suffered from lack accurate diagnostic tools available at that time. Here, using most specific sensitive to date, we report on a long-term follow-up (15 years) cohort 50 human African trypanosomiasis (HAT) patients Ivory Coast among whom 11 refused...
Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney risk, named G1 and G2, occur at high frequency. APOL1 is trypanolytic protein that confers innate resistance most trypanosomes, but not Trypanosoma brucei rhodesiense or T.b. gambiense, which cause human trypanosomiasis. this case-control study, we test prevailing hypothesis these reduce...
Background Control of gambiense sleeping sickness, a neglected tropical disease targeted for elimination by 2020, relies mainly on mass screening populations at risk and treatment cases. This strategy is however challenged the existence undetected reservoirs parasites that contribute to maintenance transmission. In this study, performed in Boffa focus Guinea, we evaluated value adding vector control medical surveys measured its impact burden. Methods The was divided into two parts (screen...
Evolutionary theory predicts that the lack of recombination and chromosomal re-assortment in strictly asexual organisms results homologous chromosomes irreversibly accumulating mutations thus evolving independently each other, a phenomenon termed Meselson effect. We apply population genomics approach to examine this effect an important human pathogen, Trypanosoma brucei gambiense. determine T.b. gambiense is asexually derived from single progenitor, which emerged within last 10,000 years....
Human African trypanosomiasis, or sleeping sickness caused by Trypanosoma brucei gambiense, occurs in Western and Central Africa. T. s.l. displays a huge diversity of adaptations host specificities, questions about its reproductive mode, dispersal abilities, effective size remain under debate. We have investigated genetic variation at 8 microsatellite loci b. gambiense strains isolated from human trypanosomiasis patients the Ivory Coast Guinea, with aim knowing how information was...
Important control efforts have led to a significant reduction of the prevalence human African trypanosomiasis (HAT) in Côte d'Ivoire, but disease is still present several foci. The existence an animal reservoir Trypanosoma brucei gambiense may explain persistence these foci where breeding important source income (AAT) unknown. aim this study was identify trypanosome species circulating domestic animals both Bonon and Sinfra HAT endemic foci.552 (goats, pigs, cattle sheep) were included....
Abstract Background The diagnosis of gambiense human African trypanosomiasis (gHAT) typically involves 2 steps: a serological screen, followed by the detection living trypanosome parasites in blood or lymph node aspirate. Live can, however, remain undetected some seropositive individuals, who, we hypothesize, are infected with Trypanosoma brucei their extravascular dermis. Methods To test this hypothesis, conducted prospective observational cohort study gHAT focus Forecariah, Republic...
Sleeping sickness, or Human African Trypanosomiasis (HAT), is caused by two distinct parasites. In East and Southern Africa, Trypanosoma brucei rhodesiense causes the Rhodesian form of disease (about 2% all reported cases [1]). Central West T. b. gambiense Gambian (G-HAT—about 98% The normally affects remote rural communities. people most at risk are those working outdoors for long periods, as they exposed to bite tsetse fly (Glossina spp.: Diptera), which transmits comparable diseases occur...
Human African trypanosomiasis (HAT), or sleeping sickness, is a fatal disease found throughout sub-Saharan Africa. The close to elimination in many areas, although it was similarly once before and subsequently reemerged, despite seemingly low rates of transmission. Determining how these foci persisted overcame an apparent transmission paradox key finally eliminating HAT. By assessing clinical, laboratory, mathematical data, we propose that asymptomatic infections contribute through the...
Strategies to detect Human African Trypanosomiasis (HAT) cases rely on serological screening of populations exposed trypanosomes. In Guinea, mass medical surveys performed with the Card Agglutination Test for have been progressively replaced by door-to-door approaches using Rapid Diagnostic Tests (RDTs) since 2016. However, RDTs availability represents a major concern and teams must often adapt, even in absence prior RDT performance evaluation. For last 5 years, Guinean HAT National Control...
ABSTRACT Babesia and Hepatozoon infections of dogs in a village eastern Sudan were analyzed by using single PCR sequencing. Among 78 dogs, 5 infected with canis rossi 2 others B. vogeli . Thirty-three positive for Hepatozoon. was detected sequence analysis.
Background Because of its high sensitivity and ease use in the field, card agglutination test for trypanosomiasis (CATT) is widely used mass screening sleeping sickness. However, CATT exhibits false-positive results (i) raising question whether CATT-positive subjects who are negative parasitology truly exposed to infection (ii) making it difficult evaluate Trypanosoma brucei (T.b.) gambiense still circulating areas low endemicity. The objective this study was assess value immune trypanolysis...
Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while rhodesiense causes an acute eastern Africa. g-HAT targeted for elimination as a public health problem 2020 0 transmission 2030 [1,2]. Control largely based on identification treatment infected individuals, supplemented control tsetse fly vectors [3]. There has been growing evidence that when both case activities are carried out...
Abstract Background Serological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis (gHAT). Presently, they preselect individuals for microscopic confirmation, but in future “screen and treat” strategies will identify treatment. Variability reported specificities, the development of new rapid diagnostic (RDT) hypothesis that malaria infection may decrease RDT specificity led us evaluate 5 gHAT tests. Methods During active screening, venous blood samples...
There is accumulating evidence for the involvement of genetic factors in human response to malaria infection, mostly based on results obtained studies severe clinical malaria. The role major gene(s) controlling blood parasitemia levels has also been detected by means segregation analysis. To confirm and localize such gene(s), we performed a sib-pair linkage analysis investigating five candidate chromosomal regions: 6p21 (HLA-tumor necrosis factor region), 2q13-q21 (genes coding interleukin-1...