A5077150072- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Malaria Research and Control
- Liver Disease Diagnosis and Treatment
- Mosquito-borne diseases and control
- Parasite Biology and Host Interactions
- Liver Disease and Transplantation
- Helminth infection and control
- Eosinophilic Disorders and Syndromes
- Parasitic infections in humans and animals
- Cytokine Signaling Pathways and Interactions
- Tuberculosis Research and Epidemiology
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- Parasitic Infections and Diagnostics
- Systemic Sclerosis and Related Diseases
- Asthma and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Trace Elements in Health
- Liver physiology and pathology
- Digestive system and related health
- Global Maternal and Child Health
- Parasitic Diseases Research and Treatment
- Immunodeficiency and Autoimmune Disorders
Inserm
2011-2020
Génétique et Immunologie des Maladies Parasitaires
2005-2020
Aix-Marseille Université
2001-2020
Assistance Publique Hôpitaux de Marseille
2009-2016
Institut de Neurobiologie de la Méditerranée
2001-2015
Hôpital de la Timone
1996-2015
Institut de Microbiologie de la Méditerranée
1999-2009
Institut National de Recherche en Santé Publique
2003-2009
University of Khartoum
2003-2009
Bipar
1999-2008
IL-17 and IL-22 have been shown to increase protection against certain bacteria fungal pathogens in experimental models. However, no human studies demonstrated a crucial role of infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates differentiation Th17 cells, produce IL-17, IL-22, IFN-gamma. Analysis Th1, Th2, cytokine responses by cultured PBMCs from individuals cohort subjects who developed KA or were protected during...
Schistosomiasis, due to Schistosoma mansoni, is a major health problem in many subtropical countries, and efforts are being made define vaccine. In this regard, we have reported that sera from subjects with low susceptibility infection by S. mansoni react larval surface antigen (P-37), having an apparent molecular mass of 37 kD, against which susceptible individuals show little reactivity. We now cloned the cDNA for screening schistosome expression library antibodies purified protein. The...
Abstract In populations exposed to Leishmania braziliensis, certain subjects develop skin ulcers, whereas others are naturally protected against cutaneous leishmaniasis. We have evaluated which cytokines most crucial in the development of lesions. found that active lesions occur with polarized Th2 or mixed Th1/Th2 responses, both associated elevated IL-10 production. was strongly (p = 0.004, odd ratio (OR) 6.8, confidence interval 1.9–25) lesions, excluding IFN-γ, IL-12, TNF, IL-13, and IL-4...
Abstract Hepatic periportal fibrosis, which affects 5–10% of subjects infected by Schistosoma mansoni, is caused the T cell-dependent granuloma that develop around schistosome eggs. Experimental models infection have shown and fibrosis are tightly regulated cytokines. However, it unknown why advanced occurs only in certain subjects. The goal present study was to evaluate cytokine response S. mansoni-infected with liver disease an attempt relate susceptibility abnormal production cytokines...
Human neurocysticercosis (NC) is a parasitic disease caused by <i>Taenia solium</i> when its larvae lodge in the central nervous system. NC prevalence estimates are obscured variable and often asymptomatic clinical picture. While infection depends on exposure, severity possibly related with various host factors (immunity, genes gender). This epidemiological study of cranial CT scans an endemic rural community found that 9.1% apparently healthy subjects had calcified lesions were...
SUMMARY Schistosomula of Schistosoma mansoni , recovered either after penetration cercariae through isolated rat skin or by mechanical transformation cercariae, become fully resistant 24–48 h culture to damage human blood eosinophils in the presence anti-schistosomular sera. Cultured schistosomula are also shown lose their susceptibility attack complement. This resistance is related simultaneous reduction ability antibodies and complement component C3 bind surface cultured larvae. The...
Selective suppression of the total IgE antibody response has been achieved in rats by injection rabbit anti-rat epsilon-chain antibodies. This IgE-specific was maintained during course a natural infection nematode Trichinella spiralis. Depletion resulted marked reduction number eosinophils attracted to T. spiralis larvae encysted striated muscle. Blood eosinophilia following infection, although reaching normal peak levels, abbreviated IgE-suppressed animals. Moreover, IgE-depleted animals...
Previous work (1)(1) has shown that normal human eosinophils show a preferential capacity, in comparison with neutrophils, to bind antibody- coated schistosomula of Schistosoma mansoni. This effect is attributable temperature-dependent function the eosinophil which renders its binding stable and irreversible by aggregated gamma globulin or Staphylococcus aureus protein A. In contrast, neutrophils readily reversible these agents. It now been differences observed between property their...
Interleukin (IL)‐22 acts on epithelia, hepatocytes, and pancreatic cells stimulates innate immunity, tissue protection, repair. IL‐22 may also cause inflammation abnormal cell proliferation. The binding of to its receptor is competed by protein (IL‐22BP), which limit the deleterious effects IL‐22. role IL‐22BP in chronic liver diseases unknown. We addressed this question individuals chronically infected with schistosomes or hepatitis C virus (HCV). first demonstrate that schistosome eggs...
Vanin-1 is a membrane-anchored pantetheinase highly expressed in the gut and liver. It hydrolyzes pantetheine to pantothenic acid (vitamin B5) low-molecular-weight thiol cysteamine. The latter believed be key regulating factor of several essential metabolic pathways, acting through sulfhydryl-disulfide exchange reactions between sulfhydryl groups enzymes oxidized form, cystamine. Its physiological importance remains elucidated, however. To explore this point, we developed Vanin-1–deficient...
Lethal disease in Schistosoma mansoni infections is mostly due to portal hypertension caused by hepatic periportal fibrosis. To evaluate the factors that may determine severe disease, livers and spleens were examined ultrasound a Sudanese population living village where S. endemic. Early (FI), moderate (FII), or advanced (FIII) fibrosis was observed 58%, 9%, 3% of population, respectively. Although FI affected 50%–70% children adolescents, FII prevalence low subjects ⩽20 years old but...
Abstract Millions of humans are exposed to schistosome infections, which cause severe kidney and liver disease 280,000 deaths annually. Th2-mediated immunity is critical human defenses against this pathogen susceptibility infection controlled by a major genetic locus that includes IL4, IL5, IL13 genes. These observations led us evaluate whether certain polymorphisms in or determine infection. The study was performed two Dogon villages where Schistosoma haematobium endemic. Schistosome...
Abstract Schistosome infection is a major public health concern affecting millions of people living in tropical regions Africa, Asia, and South America. Schistosomes cause mild clinical symptoms most subjects, whereas small proportion individuals presents severe disease (as periportal fibrosis (PPF)) that may lead to death. Severe PPF results from an abnormal deposition extracellular matrix proteins the spaces due chronic inflammation triggered by eggs schistosome Ags. Extracellular protein...
Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus schistosome infections. Hepatic (HF) may develop either slowly or rapidly schistosome-infected subjects. This depends, part, on a major genetic control exerted by genes chromosome 6q23. A gene (connective tissue growth factor [CTGF]) located that region encodes strongly fibrogenic molecule. We show single nucleotide polymorphism (SNP) rs9402373 lies close to CTGF associated...
Schistosoma eggs cause chronic liver inflammation and a complex disease characterized by hepatic fibrosis (HF) splenomegaly (SplM). FOXP3+ Tregs could regulate inflammation, but it is unclear where these cells are produced what roles they play in human schistosomiasis. We investigated blood spleen Chinese fishermen with lifelong exposure to japonicum various degrees of disease. accounted for 4.3% CD4+ T 41.2% FOXP3+CD4+ cells; be divided into CD45RA-FOXP3hi effector (eTregs) CD45RA+FOXP3low...