A5100362107- Wnt/β-catenin signaling in development and cancer
- Connective Tissue Growth Factor Research
- Liver physiology and pathology
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Genetics and Neurodevelopmental Disorders
- Autophagy in Disease and Therapy
- Cardiovascular Effects of Exercise
- Organ Transplantation Techniques and Outcomes
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Phytase and its Applications
- PI3K/AKT/mTOR signaling in cancer
- Hedgehog Signaling Pathway Studies
- Galectins and Cancer Biology
- TGF-β signaling in diseases
- Quinazolinone synthesis and applications
- FOXO transcription factor regulation
- Phytochemical compounds biological activities
- Medicinal plant effects and applications
- Kruppel-like factors research
Anhui Medical University
2014-2023
China Agricultural University
2022
Second Hospital of Anhui Medical University
2021
Ministry of Education of the People's Republic of China
2013-2019
Army Medical University
2012-2018
Sun Yat-sen University
2018
Third Affiliated Hospital of Sun Yat-sen University
2018
Institute of Immunology
2018
Capital Medical University
2015-2017
National Clinical Research Center for Digestive Diseases
2016-2017
Abstract Inflammation can cause endoplasmic reticulum (ER) stress and therefore activates the unfolded protein response (UPR). ER consequent UPR have potential to activate NF-κB. However, factors mediating crosstalk between NF-κB pathway remain unclear. Here, we determined that inducible Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases inflammatory disease models. caused MANF relocalize nuclei. interacted with DNA binding domain of p65...
It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. However, precise mechanisms underlying oncogenic role of TFAP4 remain largely unknown. Methods: expression levels hepatocellular carcinoma (HCC) cells tissues were detected by quantitative real-time PCR (qPCR) immunohistochemistry (IHC). In vitro vivo assays performed to investigate function tumor-initiating cell...
Abstract Peroxisome proliferator-activated receptor (PPAR)-γ is involved in both normal physiological processes and pathology of various diseases. The purpose this study was to explore the function underlying mechanisms PPAR-γ rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) proliferation migration. In present study, we found expression remarkably reduced RA synovium patient compare with OA normal, as well it low-expression Adjuvant-induced (AA). Moreover, inhibition by T0070907...
A number of macrophage phenotypes have been previously identified as crucial regulators in the progression hepatic fibrosis (HF). Cytokines from macrophages or Kupffer cells (KCs) also to be important HF. Blocking Kv1.3 models HF, regulating polarization and cytokine secretion not yet assessed potential treatments options for this condition. In current study, a model carbon tetrachloride (CCl4)‑induced HF was established examined effects margatoxin (MgTX; an inhibitor Kv1.3) on Hematoxylin...
Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus schistosome infections. Hepatic (HF) may develop either slowly or rapidly schistosome-infected subjects. This depends, part, on a major genetic control exerted by genes chromosome 6q23. A gene (connective tissue growth factor [CTGF]) located that region encodes strongly fibrogenic molecule. We show single nucleotide polymorphism (SNP) rs9402373 lies close to CTGF associated...
Abnormal activation of the canonical Wnt signaling pathway has been implicated in carcinogenesis. Transcription target genes is regulated by nuclear β-catenin, whose over-expression observed Hepatocellular Carcinoma (HCC) tissue. Cyr61, a member CCN complex family multifunctional proteins, also found over-expressed many types tumor and plays dramatically different roles tumorigenesis. In this study, we investigated relationship between Cyr61 β-catenin HCC. We that while protein was not...
Abstract Low-density lipoprotein receptor-related protein 6 (LRP6) is a Wnt co-receptor in the canonical Wnt/β-catenin signalling. Here, we report scaffold function of LRP6 gap junction formation cardiomyocytes. Cardiac spatially restricted to intercalated discs and binds connexin 43 (Cx43). A deficiency disrupts Cx43 thereby impairs cell-to-cell coupling, which independent The defect resulting from reduction attributable defective traffic de novo proteins endoplasmic reticulum Golgi...
Adiponectin, an adipocyte-derived hormone, exerts pleiotropic biological effects on metabolism, inflammation, vascular homeostasis, apoptosis and immunity. Recently, adiponectin has been suggested to attenuate the progression of human dermal fibrosis. Connective tissue growth factor (CTGF) is induced in keloids thought be participated formation keloid However, roles played by remain unclear. In this study, we explored CTGF-induced cell proliferation, migration deposition extracellular matrix...