A5007054708- RNA modifications and cancer
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Liver physiology and pathology
- Genetics and Neurodevelopmental Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- HVDC Systems and Fault Protection
- Organ Transplantation Techniques and Outcomes
- Mitochondrial Function and Pathology
- Atrial Fibrillation Management and Outcomes
- RNA regulation and disease
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Neonatal Respiratory Health Research
- Adipokines, Inflammation, and Metabolic Diseases
Anhui Medical University
2015-2025
Second Hospital of Anhui Medical University
2015-2025
Feed Research Institute
2022-2024
Chinese Academy of Agricultural Sciences
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
XinHua Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
First Affiliated Hospital of Anhui Medical University
2023-2024
Nanjing Medical University
2020-2024
University Hospital Carl Gustav Carus
2024
Abstract In addition to their use in relieving the symptoms of various diseases, ketogenic diets (KDs) have also been adopted by healthy individuals prevent being overweight. Herein, we reported that prolonged KD exposure induced cardiac fibrosis. rats, or frequent deep fasting decreased mitochondrial biogenesis, reduced cell respiration, and increased cardiomyocyte apoptosis Mechanistically, levels ketone body β-hydroxybutyrate (β-OHB), an HDAC2 inhibitor, promoted histone acetylation Sirt7...
Abstract Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, compared healthy controls, display reduced succinate dehydrogenase complex iron sulfur subunit (SDHB) DNA methylation, elevated SDHB expression, levels, indicating low levels correlate with...
Heart failure is associated with a high rate of mortality and morbidity, ventricular remodeling invariably precedes heart failure. Ventricular fundamentally driven by mechanotransduction that regulated both the nervous system immune system. However, it remains unknown which key molecular factors govern neuro/immune/cardio axis underlies during remodeling. Here, we investigated whether mechanosensitive Piezo cation channel-mediated neurogenic inflammatory cascade remodeling-related...
With the rapid advancement of genetic and protein engineering, proteins peptides have emerged as promising drug molecules for therapeutic applications. Consequently, there has been a growing interest in field chemical modification technology to address challenges associated with their clinical use, including clearance from circulation, immunogenicity, physical instabilities (such aggregation, adsorption, deamination, clipping, oxidation, etc.), enzymatic degradation. Polyethylene glycol...
The aberrant expression of transforming growth factor (TGF)-beta1 in the tumor microenvironment and fibrotic lesions plays a critical role progression tissue fibrosis by inducing epithelial-mesenchymal transition (EMT). EMT promotes cell motility invasiveness. How affects invasion is not well understood. Here we report that HDAC6 novel modulator TGF-beta1-induced EMT. microtubule-associated deacetylase predominantly deacetylates nonhistone proteins, including alpha-tubulin, regulates...
Dysregulated mitochondrial metabolism occurs in several pathological processes characterized by cell proliferation and migration. Nonetheless, the role of fission is not well appreciated cardiac fibrosis, which accompanied enhanced fibroblast We investigated causes consequences fibrosis using cultured cells, animal models, clinical samples. Increased METTL3 expression caused excessive fission, resulting migration fibroblasts that lead to fibrosis. Knockdown suppressed inhibiting for...
Mitochondrial metabolism plays a pivotal role in various cellular processes and fibrosis. However, the mechanism underlying mitochondrial metabolic function liver fibrosis remains poorly understood. In this study, we determined whether mediates using cells, animal models, clinical samples to elucidate potential effects of We report that AlkB Homolog 5 (ALKBH5) decreases membrane (MMP) oxygen consumption rate (OCR), suppresses fission hepatic stellate cell (HSC) proliferation migration...
Folate deficiency is an independent risk factor for congenital heart disease (CHD); however, the maternal plasma folate level paradoxically not a good diagnostic marker. Genome-wide surveys have identified variants of nonfolate metabolic genes associated with level, suggesting that these genetic polymorphisms are potential factors CHD.To examine effects concentration-related variations on CHD in Han Chinese population, we performed 3 case-control studies including total 1489 patients and...