A5100352432- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Chinese history and philosophy
- Cancer, Hypoxia, and Metabolism
- Acute Ischemic Stroke Management
- Lung Cancer Treatments and Mutations
- Cerebrovascular and Carotid Artery Diseases
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
- Advanced Breast Cancer Therapies
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Helicobacter pylori-related gastroenterology studies
- Inflammasome and immune disorders
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Protein Degradation and Inhibitors
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Chongqing University
2024
Central South University
2010-2024
Hunan Cancer Hospital
2018-2024
Lanzhou University
2012-2024
First Hospital of Lanzhou University
2018-2024
Weifang People's Hospital
2011-2024
Weifang Medical University
2011-2024
Capital Medical University
2010-2023
Localized tissue hypoxia is a consequence of vascular compromise or rapid cellular proliferation and potent inducer compensatory angiogenesis. The oxygen-responsive transcriptional regulator hypoxia-inducible factor 2α (HIF-2α) highly expressed in ECs and, along with HIF-1α, activates expression target genes whose products modulate functions However, the mechanisms by which HIF-2α regulates EC function perfusion under physiological pathological conditions are poorly understood. Using mice...
Abstract The poor prognosis of malignant gliomas is largely attributed to their highly invasive nature. molecular mechanism underlying the invasiveness glioma cells, however, remains be elucidated. present study found that astrocyte elevated gene-1 (AEG-1) was upregulated in human cell lines and tissues compared with normal astrocytes brain tissues. AEG-1 265 296 (89.5%) sections, expression level significantly correlated clinicopathologic stages gliomas. Ectopic or short hairpin RNA...
The overexpression of hypoxia-inducible factor 1α (HIF-1α) is a common finding in hepatocellular carcinoma (HCC), and it leads to angiogenesis poor prognosis. Sorafenib, multikinase inhibitor, has shown significant improvement survival patients with advanced HCC clinical trials. However, the mechanisms that account for antiangiogenic efficiency sorafenib have not been fully elucidated. present study aims explore effect on HIF-1α expression activation cells xenografts.HCC xenografts were...
Abstract The transcription coactivator YAP plays a vital role in Hippo pathway for organ-size control and tissue homeostasis. Recent studies have demonstrated is closely related to immune disorders inflammatory diseases, but the underlying mechanisms remain less defined. Here, we find that promotes activation of NLRP3 inflammasome, an intracellular multi-protein complex orchestrates host responses infections or sterile injuries. deficiency myeloid cells significantly attenuates LPS-induced...
Abstract A potential mechanism by which green tea may prevent cancer development is through the inhibition of angiogenesis. We have shown previously that catechin, epigallocatechin gallate (EGCG), inhibits endothelial cell tube formation vascular growth factor (VEGF)‐induced Akt activation and (VE)‐cadherin phosphorylation. Furthermore, EGCG can suppress oxidant‐induced production proangiogenic cytokine interleukin (IL)‐8. To further elucidate antiangiogenic mechanisms EGCG, we investigated...
PurposeIn cancer patients, tumor gene mutations contribute to drug resistance and treatment failure. In patients with metastatic breast (MBC), these increase after multiline treatment, thereby decreasing efficiency. The aim of this study was evaluate mutation patterns in MBC predict disease progression.MethodA total 68 who had received were recruited. Circulating DNA (ctDNA) evaluated compared among hormone receptor (HR)/human epidermal growth factor 2 (HER2) subgroups.ResultsThe baseline...
Fatty acid binding protein 4 (FABP4), a subtype of fatty acid-binding family, shows critical roles in metabolism and inflammation. However, its on regulating renal interstitial fibrosis (RIF) remain unclear. In this work, LPS-stimulated vitro models NRK-52E NRK-49F cells, vivo UUO rats mice were established. The results showed that comparing with control groups or sham groups, the expression levels α-SMA, COL1A, COL3A, IL-1β, IL-6, TNF-α cells animals significantly increased. Meanwhile, TC,...
Patients with HER2-positive (HER2+) metastatic breast cancer (MBC) have poor prognoses. Pyrotinib has shown promising antitumor activity in MBC to improve progression-free survival (PFS). However, findings based on real-world data analyze whether pyrotinib affects overall (OS) remain scarce.This study is an exploratory analysis of brain metastasis (BM) and the final update our preceding 168 patients HER2+ MBC. PFS, OS, tumor mutation burden (TMB), clinical benefit rate (CBR), response (ORR)...
The purpose of this study was to investigate the therapeutic effect berberine (BBR) on MNNG-induced chronic atrophic gastritis (CAG) and possible mechanism BBR through TGF-β1/PI3K signal pathway. GES-1 were pretreated with MNNG for 2 h before treatment in all procedures. Cell viability quantified by cell counting kit-8, morphology proliferation detected high content screening (HCS) assay. rat model CAG established MNNG, stomach histopathology serum supernatant analyzed vivo . In addition,...
In advanced cirrhosis, impaired function is caused by intrinsic damage to the native liver cells and from abnormal microenvironment in which reside. The extent each plays a role failure regeneration unknown. To examine this issue, hepatocytes cirrhotic age-matched control rats were isolated, characterized, transplanted into livers of noncirrhotic hosts whose permit extensive repopulation with donor cells. Primary derived cirrhosis compensated maintained metabolic activity ability secrete...
Abstract Background The prognosis of human glioma is poor, and the highly invasive nature disease represents a major impediment to current therapeutic modalities. oncoprotein B-cell-specific Moloney murine leukemia virus integration site 1 protein (Bmi-1) has been linked development progression glioma; however, biological role Bmi-1 in invasion remains unclear. Methods A172 LN229 cells were engineered overexpress via stable transfection or be silenced for expression using RNA interfering...
To design a shared scenic mobility scooter that is more in line with the smart city lead. This paper proposes KJ-AHP integration method to assist of intelligent scooters.First, list user functional requirements mined through KJ method.Secondly, AHP used filter and construct hierarchical model calculate weight values each factor output prioritised results.Finally, appropriate strategies are proposed.The has certain operability superiority, providing scientific reference basis for later...