A5056443419- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Advanced Biosensing Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Intraperitoneal and Appendiceal Malignancies
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
Henan Cancer Hospital
2015-2025
Zhengzhou University
2013-2025
Inner Mongolia Agricultural University
2024-2025
Xi’an Jiaotong-Liverpool University
2025
Zhejiang University
2018-2025
Second Hospital of Anhui Medical University
2022-2025
Anhui Medical University
2022-2025
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Second Affiliated Hospital of Zhejiang University
2016-2024
One of the most fundamental questions in biology is what types cells form different tissues and organs a functionally coordinated fashion. Larger-scale single-cell sequencing experiment studies are now rapidly opening up new ways to track this question by revealing substantial cell markers for distinguishing tissues. Here, we developed CellMarker database (http://biocc.hrbmu.edu.cn/CellMarker/ or http://bio-bigdata.hrbmu.edu.cn/CellMarker/), aiming provide comprehensive accurate resource...
High functional heterogeneity of cancer cells poses a major challenge for research. Single-cell sequencing technology provides an unprecedented opportunity to decipher diverse states at single-cell resolution, and scRNA-seq datasets have been largely accumulated. This emphasizes the urgent need build dedicated resource decode single cells. Here, we developed CancerSEA (http://biocc.hrbmu.edu.cn/CancerSEA/ or http://202.97.205.69/CancerSEA/), first database that aims comprehensively explore...
In the phase III IMpassion130 trial, combining atezolizumab with first-line nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) showed a statistically significant progression-free survival (PFS) benefit in intention-to-treat (ITT) and programmed death-ligand 1 (PD-L1)-positive populations, clinically meaningful overall (OS) effect PD-L1-positive aTNBC. The KEYNOTE-355 trial adding pembrolizumab to chemotherapy aTNBC similar PFS effects. IMpassion131...
// Hao Li 1 , Beiqin Yu Jianfang Liping Su Min Yan Zhenggang Zhu Bingya Liu Shanghai Key Laboratory of Gastric Neoplasms, Institute Digestive Surgery, Ruijin Hospital, Jiao Tong University School Medicine, 200025, People’s Republic China. Correspondence: Liu, email: Keywords : gastric cancer, long non-coding RNA, H19, microRNA, miR-675 Received March 04, 2014 Accepted April 16, Published 18, Abstract Long RNAs (lncRNAs) play key roles in the progression and metastasis some carcinomas....
: Systematically tracking the tumor immunophenotype is required to understand mechanisms of cancer immunity and improve clinical benefit immunotherapy. However, progress in current research hindered by lack comprehensive immune activity resources easy-to-use tools for biologists, clinicians, researchers conveniently evaluate during "cancer-immunity cycle." We developed a user-friendly one-stop shop web tool called TIP comprehensively resolve immunophenotype. has capability rapidly analyze...
Cancer-associated fibroblasts (CAFs), as the activated in tumor stroma, are important modifiers of progression. However, molecular mechanisms underlying tumor-promoting properties CAFs gastric cancer remain unclear. Here, we show that isolated from produce significant amounts interleukin-6 (IL-6). enhances migration and EMT cells through secretion IL-6 activates Janus kinase 2/signal transducers activators transcription (JAK2/STAT3) pathway cells, while deprivation using a neutralizing...
Gastric cancer (GC) has a clear predilection for metastasis toward the omentum which is primarily composed of adipose tissue, indicating that fatty acids may contribute to this phenomenon. However their function remains poorly understood in GC. In study, we investigated role palmitate acid (PA) and its cellular receptor CD36 progression GC.Immunohistochemical (IHC) staining was performed detect expression GC tissues clinical significance determined statistically. over-expression knock-down...
Prostate cancer is a highly prevalent tumor affecting millions of men worldwide, but poor understanding its pathogenesis has limited effective clinical management patients. In addition to transcriptional profiling or transcriptomics, metabolomics being increasingly utilized discover key molecular changes underlying tumorigenesis. this study, we integrated transcriptomics and analyze 25 paired human prostate tissues adjacent noncancerous tissues, followed by further validation our findings in...
Abstract Centrosome-localized mitotic Aurora kinase A (AURKA) facilitates G2/M events. Here we show that AURKA translocates to the nucleus and causes distinct oncogenic properties in malignant cells by enhancing breast cancer stem cell (BCSC) phenotype. Unexpectedly, this function is independent of its activity. Instead, preferentially interacts with heterogeneous nuclear ribonucleoprotein K (hnRNP K) acts as a transcription factor complex induces shift MYC promoter usage activates promoter....
As the predominant immunosuppressive component within tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) inhibit Natural Killer cell (NK cell) activity to promote progression and immune escape; however, mechanisms of cross-talk between CAFs NK cells in gastric cancer (GC) remain poorly understood. In this study, we demonstrate that levels are inversely correlated with abundance human GC. impair anti-tumor capacity by inducing ferroptosis, a death process characterized...
We have previously shown that elevated expression of mitotic kinase aurora A (AURKA) in cancer cells promotes the development metastatic phenotypes and is associated clinically with adverse prognosis. Here, we first revealed a positive correlation between AURKA autophagy-associated protein SQSTM1 breast further demonstrated regulated through autophagy. Indeed, depletion by siRNA or chemical inhibition small molecule VX-680 increased both level microtubule-associated 1 light chain 3-II...
Oncolytic virotherapy is a growing treatment modality that uses replicating viruses as selective antineoplastic agents. Safety and efficacy considerations dictate an ideal oncolytic agent would discriminate between normal cancer cells on the basis of common genetic abnormalities in human cancers. Here, we identify naturally occurring alphavirus (M1) novel killer targeting zinc-finger antiviral protein (ZAP)-deficient cells. In vitro, vivo, ex vivo studies showed potent high tumor tropism M1....
Abstract In-depth delineation of lipid metabolism in prostate cancer (PCa) is significant to open new insights into tumorigenesis and progression, provide potential biomarkers with greater accuracy for improved diagnosis. Here, we performed lipidomics transcriptomics paired tumor (PCT) adjacent nontumor (ANT) tissues, followed by external validation biomarker candidates. We identified major dysregulated pathways involving lipogenesis, uptake phospholipids remodeling, correlated widespread...