A5035951209- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
- Ferroptosis and cancer prognosis
- Parasites and Host Interactions
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Photosynthetic Processes and Mechanisms
- Lung Cancer Treatments and Mutations
- Genetics, Aging, and Longevity in Model Organisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mitochondrial Function and Pathology
- Cancer Mechanisms and Therapy
- Algal biology and biofuel production
- Cardiovascular and Diving-Related Complications
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Genetic and phenotypic traits in livestock
- Helminth infection and control
Sun Yat-sen University
2008-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2021-2025
Zhongshan Hospital
2022-2025
Fudan University
2020-2025
Wannan Medical College
2021-2025
Capital Medical University
2024-2025
Beijing Friendship Hospital
2024-2025
Jimei University
2025
Nanjing Medical University
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2022-2025
Metastasis leads to poor prognosis in colorectal cancer patients, and there is a growing need for new therapeutic targets. TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as calcium-activated chloride channel (CaCC) reported be overexpressed several malignancies; however, its expression function (CRC) remains unclear. In this study, we found of mRNA protein high-metastatic-potential SW620, HCT116 LS174T cells, but not primary HCT8 SW480 using RT-PCR, western blotting...
Porokeratosis (PK) is a heterogeneous group of keratinization disorders. No causal genes except MVK have been identified, even though the disease was linked to several genomic loci. Here, we performed massively parallel sequencing and exonic CNV screening 12 isoprenoid in 134 index PK patients (61 familial 73 sporadic) identified mutations three novel ( PMVK , MVD FDPS ) addition mevalonate pathway. Allelic expression imbalance (AEI) assays were 13 lesional tissues. At least one mutation...
Circulating extracellular vesicles (EVs) were recognized as a promising source of diagnostic biomarker. However, there are limited studies published in this area, partly due to the number detection platforms capable detecting vesicles. In study, vesicle immunoassays developed using Single Molecule array technology (SiMoa) and their clinical applications cancer diagnosis evaluated. Two assays, CD9-CD63 Epcam-CD63, designed detect universal tumour-derived vesicles, respectively. Our results...
Abstract Introduction Mesenchymal stem cells (MSCs) exert immunomodulatory functions by inducing the development and differentiation of naive T into with an anti-inflammatory regulatory cell (Treg) phenotype. Our previous study showed that hepatocyte growth factor (HGF) secreted MSCs had effects in context lipopolysaccharide (LPS) stimulation. We hypothesized HGF is a key MSC-mediated regulation helper 17 (Th17) cell/regulatory balance. Methods investigated on CD4+ Th17/Treg response to LPS...
Pyrotinib (an irreversible pan-ErbB inhibitor) plus capecitabine has survival benefits and acceptable tolerability in patients with HER2-positive metastatic breast cancer. We further assessed addition of pyrotinib to trastuzumab docetaxel the neoadjuvant setting. In this multicenter, double-blind, phase 3 study (PHEDRA), treatment-naive women early or locally advanced cancer were randomly assigned (1:1) receive four cycles oral placebo (400 mg) once daily, intravenous (8 mg/kg loading dose,...
Breast cancer (BC) is the most diagnosed in women. Cuproptosis new regulated cell death, distinct from known death mechanisms and dependent on copper mitochondrial respiration. However, comprehensive relationship between cuproptosis BC still blank until now. In present study, we acquired 13 cuproptosis-related regulators (CRRs) previous research downloaded RNA sequencing data of TCGA-BRCA UCSC XENA database. The CRRs were all differently expressed normal samples. Using consensus clustering...
Breast cancer brain metastases (BCBM) are the most fatal, with limited survival in all breast distant metastases. These patients deemed to be incurable. Thus, time is their foremost concern. However, there a lack of accurate prediction models clinic. What's more, primary surgery for BCBM still controversial.The data used analysis this study was obtained from SEER database (2010-2019). We made COX regression identify prognostic factors patients. Through cross-validation, we constructed...
Abstract Background Ovarian cancer (OC) has the highest mortality rate among all gynecological malignancies. A hypoxic microenvironment is a common feature of solid tumors, including ovarian cancer, and an important driving factor tumor cell survival chemo- radiotherapy resistance. Previous research identified hypoxia-associated gene angiopoietin-like 4 (ANGPTL4) as both pro-angiogenic pro-metastatic in tumors. Hence, this work aimed to further elucidate contribution ANGPTL4 OC progression....
Essential tremor (ET) is one of the most common movement disorders in human adults. It can be characterized as a progressive neurological disorder which recognizable feature arms or hands that apparent during voluntary movements such eating and writing. The pathology ET remains unclear. Resting-state fMRI (RS-fMRI), non-invasive imaging technique, was employed to investigate abnormalities functional connectivity brain. Regional homogeneity (ReHo) used metric RS-fMRI assess local abnormality...
EMT is a pivotal mechanism involved in tumor metastasis, which the leading cause of poor prognosis for hepatocellular carcinoma (HCC). Sirtuin family members function as NAD+-dependent deacetylases that are essential metastasis and epithelial-mesenchymal transition (EMT). However, no causal association has been established between Sirtuin6 (SIRT6) HCC metastasis. SIRT6 expression pattern its with were investigated by informatic analysis, verified qRT-PCR immunochemistry tissues. Transwell...
AIM: The aim of this study was to observe the possible change microRNAs (miRNAs) in serum extracellular vesicles (EVs) from hepatocellular carcinoma (HCC) patients. METHODS: were purified seventeen healthy donors, sixteen chronic hepatitis B (CHB) patients and twenty-four HCC sequenced analyzed obtain highly differentially expressed genes (DEGs). Finally, expression pattern DEGs validated using qRT-PCR. RESULTS: We found that hsa-miR-21-5p hsa-miR-144-3p significantly higher liver cancer...
Sepsis is one of the serious disorders in clinical practice. Recent studies found toll-like receptors 4 (TLR4) played an important role sepsis. In this study, we tried to find influence Corilagin on TLR4 signal pathways vitro and vivo.The cellular animal models sepsis were established by LPS then interfered with Corilagin. Real-time PCR western blot employed detect mRNA protein expressions TLR4, MyD88, TRIF TRAF6. ELISA was used determine IL-6 IL-1β levels supernatant serum.The survival rate...
Background Breast cancer is the most common worldwide. Hypoxia and lactate metabolism are hallmarks of cancer. This study aimed to construct a novel hypoxia- metabolism-related gene signature predict survival, immune microenvironment, treatment response breast patients. Methods RNA-seq clinical data from The Cancer Genome Atlas database Gene Expression Omnibus were downloaded. Hypoxia- genes collected publicly available sources. differentially expressed identified using “edgeR” R package....
Importance Preferred neoadjuvant strategies for early or locally advanced triple-negative breast cancer include a 4-drug chemotherapy regimen containing anthracyclines, cyclophosphamide, taxanes, and platinum. Blockade of the programmed death receptor 1/ligand-1 (PD-1/PD-L1) pathway may improve efficacy classic chemotherapy. Camrelizumab, an anti–PD-1 antibody, has showed antitumor activity in cancer. Objective To evaluate adverse events camrelizumab plus vs placebo as therapy patients with...
Background. Based on PACIFIC trial, durvalumab as consolidation therapy following concurrent chemoradiotherapy (cCRT) has been a new standard treatment for unresectable stage III non-small cell lung cancer (NSCLC). In clinical applications, there are heterogeneous adjustments or novel strategies specialized discussions in experienced multidisciplinary teams. This study retrospectively compared the efficacy and safety of different first-line treatments NSCLC. Methods. We analyzed 397 patients...
Abstract Breast cancer has become the most commonly diagnosed cancer. The intra‐ and interpatient heterogeneity induced a considerable variation in treatment efficacy. There is an urgent requirement for preclinical models to anticipate effectiveness of individualized drug responses. Patient‐derived organoids (PDOs) can accurately recapitulate architecture biological characteristics origin tumor, making them promising model that overtake many limitations cell lines PDXs. However, it still...
// Guoying Zhang 1,2 , Xinshan Ye 2 Dexin Ji 1,* Huarong Fujia Sun Chunqing Shang Ying 1,3,* Erxi Wu 3 Fengfei Wang Fei 1 Huihui Tian Xin Liu Linlin Chen Kun ,Yishan 4 Hanchen , Wenhua Yukun Guan Qinwen 5 Xiaohang Zhao 6 and Xiaochun Wan 7 Laboratory of Molecular Pharmacology, School Pharmacy, Yantai University, Qing Quan Lu, Yantai, Shandong Province, China State Key Natural Biomimetic Drugs, Peking Beijing, P R Department Pharmaceutical Sciences, North Dakota Fargo, ND, USA The Center...
Recent breakthroughs in therapies with immune checkpoint inhibitors (ICIs) have revolutionized the treatment of lung cancer. However, only 15-25% patients respond to ICIs therapy, and methods identify those responsive are currently a hot research topic. PD-L1 expression measured on tumor tissues using immunohistochemistry (IHC) was approved as one companion diagnostic methods, but it is invasive cannot be used monitor dynamic changes during treatments.In this study, we developed an...