A5064592929- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Morinda citrifolia extract uses
- Berberine and alkaloids research
- Systemic Lupus Erythematosus Research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Pancreatitis Pathology and Treatment
- Traditional Chinese Medicine Analysis
- Rheumatoid Arthritis Research and Therapies
- Intracerebral and Subarachnoid Hemorrhage Research
- Galectins and Cancer Biology
- Liver Disease Diagnosis and Treatment
- Soil Carbon and Nitrogen Dynamics
- Circadian rhythm and melatonin
- Gout, Hyperuricemia, Uric Acid
- Marine Biology and Ecology Research
- Endometrial and Cervical Cancer Treatments
- Digestive system and related health
- Pediatric Hepatobiliary Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
Fudan University
2024
Zhongshan Hospital
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Guangzhou University of Chinese Medicine
2023
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023
Peking University
2001-2022
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2022
Peking University Third Hospital
2021-2022
Hunan Provincial People's Hospital
2021
The gut microbiota is recognized as a promising therapeutic target for anxiety. Berberine (BBR) has shown efficacy in the treatment of diseases such postmenopausal osteoporosis, obesity, and type 2 diabetes through regulating microbiota. However, effects BBR on anxiety are still unclear. purpose study to test whether ameliorates by modulating intestinal under estrogen-deficient conditions. Experimental was established specific pathogen-free (SPF) ovariectomized (OVX) rats, which were then...
Accumulating evidence shows that agents targeting gut dysbiosis are effective for improving symptoms of irritable bowel syndrome (IBS). However, the potential mechanisms remain unclear. In this study we investigated effects berberine on microbiota-gut-brain axis in two rat models visceral hypersensitivity, i.e., specific pathogen-free SD rats subjected to chronic water avoidance stress (WAS) and treated with (200 mg· kg-1 ·d-1, ig, 10 days) as well germ-free (GF) fecal microbiota...
Intestinal melatonin exerts diverse biological effects on the body. Our previous research showed that abundance of butyrate-producing bacteria, Roseburia, is positively related to expression colonic mucosal melatonin. However, detailed relationship unclear. Therefore, we aimed explore whether Roseburia regulates intestinal and its underlying mechanisms. Male Sprague-Dawley germfree rats were orally administered with or without hominis. R. hominis treatment significantly increased level. The...
Rubia cordifolia L. (Rubiaceae), one of the traditional anti-rheumatic herbal medicines in China, has been used to treat rheumatoid arthritis (RA) since ancient times. Purpurin, an active compound L., identified previous studies and exerts antibacterial, antigenotoxic, anticancer, antioxidant effects. However, efficacy underlying mechanism purpurin alleviate RA are unclear. In this study, effect on inflammation was investigated using macrophage RAW264.7 inflammatory cells, induced by...
Targeted and immunotherapy combined with interventional therapy can improve the prognosis of advanced cancer patients, it has become a hot spot to find new therapeutic schemes, but most which are not satisfactory. Single-cell RNA sequencing was performed in PDX mouse models or without TCC therapy. 2-'O-Methylation modification multiplex immunofluorescence staining were used explore function mechanism SAMD4B immune context HCC. Here, we propose for first time synergistic immunochemotherapy...
Endometriosis is well known as a chronic inflammatory disease. The development of endometriosis heavily influenced by the estrogen receptor β (ERβ), while NOD-like receptors (NLRs) family CARD domain-containing 5 (NLRC5) exhibits anti-inflammatory properties during endometriosis. However, whether NLRC5-mediated anti-inflammation involved in ERβ-mediated still uncertain. This study aimed to assess that relation. Nine cases eutopic endometrial tissue and ten ectopic were collected from...
Purpose: Rubia cordifolia L. (RC) is a classic herbal medicine for the treatment of rheumatoid arthritis (RA) and has been used since ancient times.The ethanol extract (RCE) showed obvious anti-RA effects in our previous study.However, further potential mechanisms require more exploration.We aimed to investigate mechanism RCE RA by integrating metabolomics network pharmacology this study.Methods: An adjuvant-induced (AIA) rat model was established, we evaluated therapeutic RCE.Metabolomics...
Abstract Background: As a non-invasive and effective diagnostic method for small intestinal bacterial overgrowth (SIBO), wild-use of breath test (BT) has demonstrated high comorbidity rate in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) SIBO. Patients overlapping SIBO respond better to rifaximin therapy than those IBS-D only. Gut microbiota plays critical role both these two diseases. We aimed determine the microbial difference between with/without SIBO, study...
Understanding the influence of fertilizer on soil quality is vital to agricultural management, yet there are few studies, particularly in black soil. In this study, soils under various treatments, namely no fertilizer, bio-organic + humic acid, chemical, and chemical were sampled identify their major physiochemical properties, investigate fungal community structure using environmental sequencing techniques. Physiochemical properties examined at four important stages maize life cycle:...
This paper focused on evaluating the effect of TLR4-MyD88-NF-κB signaling pathway in progression secondary hepatic injury and fibrosis hepatolithiasis. The levels inflammatory factors (IL-1β, IL-6, TNF-α) serum biochemical values (ALT, AST, Tbil, Dbil, ALP, GGT) were detected by ELISA. IHC was used to expression level TLR4 liver tissues hepatolithiasis patients mice. pathological changes tissue observed HE staining. MyD88, NF-κB, IκB, Laminin (LN), chitosan enzyme 3-like protein 1 (CHI3L1)...
Urbanization of coastal areas poses a severe threat to ecologically valuable intertidal wetlands. This paper presents pragmatic approach called Rapid Assessment for Intertidal Wetland Sediments (RAITWS) evaluating the sediment quality RAITWS involves construction reference groups, selection subset environmental variables, matching test sites prediction benthic fauna community structure (e.g. macroinvertebrates) at sites, evaluation Observation Expectation ratio (O/E ratio), quantification...
Introduction: Gouty arthritis (GA) is induced by a purine metabolism disorder and monosodium urate (MSU) crystal-related inflammation. Berberine (BBR), extracted from Coptis chinensis, ameliorates MSU-induced GA. However, the mechanisms of BBR against GA remain to be fully elucidated. This study aimed identify key targets pathways mediating effects using network pharmacology. Methods: were obtained several databases, BBR-GA common was visualized Cytoscape software. Protein–protein...
Background: Accumulating evidence indicates that agents targeting gut dysbiosis are effective on improving symptoms in irritable bowel syndrome (IBS). However, the potential mechanisms remain unclear. Here, we investigated roles of berberine modulating microbiota-gut-brain axis models IBS. Methods: Two were used to mimic brain-gut dysfunction. Specific pathogen-free Sprague Dawley (SD) rats subjected water avoidance stress (WAS) and treatment, germ-free (GF) SD underwent fecal microbiota...