A5100397251- Endometrial and Cervical Cancer Treatments
- Malaria Research and Control
- Mosquito-borne diseases and control
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Endometriosis Research and Treatment
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Viral Infections and Vectors
- Uterine Myomas and Treatments
- Hepatitis C virus research
- Lung Cancer Treatments and Mutations
- Gynecological conditions and treatments
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glycosylation and Glycoproteins Research
- Gastrointestinal disorders and treatments
- Osteoarthritis Treatment and Mechanisms
- Immunotherapy and Immune Responses
- Zoonotic diseases and public health
- Reproductive System and Pregnancy
- Computational Drug Discovery Methods
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Obstetrics and Gynecology Hospital of Fudan University
2018-2024
North Sichuan Medical University
2023-2024
Capital Medical University
2010-2024
Chengdu Third People's Hospital
2023-2024
Tianjin University of Traditional Chinese Medicine
2022-2024
Zhejiang University
2024
Harbin Institute of Technology
2024
Shandong University
2008-2024
This study aimed to evaluate the efficacy of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young patients endometrial atypical hyperplasia (EAH) early stage cancer (EEC) who wished preserve their fertility.Patients EAH (n = 120) or well-differentiated EEC 40, FIGO IA, without myometrial invasion) were retrospectively included. All received constant oral every 3 months until achieving complete response (CR). The location, number size each...
The contribution of hepatitis B virus (HBV) and C (HCV) to primary liver cancer (PLC) their association with aggressiveness remains uncertain in China, a country half global PLC. We aimed characterize this using data from four representative medical centers.In total, 15,801 PLC patients were enrolled the centers distributed Easter5n, Southern, Northern, Western China 2003 2020. Of those, 7585 curative surgery involved survival analysis. A nomogram was constructed preoperative parameters...
Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These can be used to stratify individuals by their cancer.
Gene expression profiling provides an opportunity to develop robust prognostic markers of colorectal carcinoma (CRC). However, the have not been applied for clinical decision making. We aimed immunohistochemistry signature using microarray data predicting CRC prognosis.We evaluated 25 gene signatures in independent datasets with prognosis information and constructed a subnetwork high concordance repeatable values. Tumours were examined immunohistochemically network-centric top overlapping...
Hepatitis B virus (HBV) mutations and signal transducer activator of transcription 3 (STAT3) activation are closely associated with hepatocellular carcinoma (HCC). However, single nucleotide polymorphisms (SNPs) STAT3 have not been implicated in HCC susceptibility. This study was designed to evaluate the effect SNPs their interactions HBV on risk. A total 2,011 HBV-infected subjects (including 1,021 patients) 1,012 healthy controls were involved this study. rs4796793 (−1697, C>G), rs2293152...
Disaster is a serious public health issue. Health professionals and community residents are main players in disaster responses but their knowledge levels of medicine not readily available. This study aimed to evaluate training needs among potential responders presented necessity popularize education.A self-reporting questionnaire survey on level was conducted Shanghai, China, 2012. A total randomly selected 547 professionals, 456 medical students, 1,526 local provided intact information. The...
Genetic polymorphisms of HLA-DP have been associated with hepatitis B virus (HBV) persistence. We aimed to determine the effect on generation HBV mutations and their interactions outcomes infection. rs3077, rs3135021, rs9277535, rs2281388 were genotyped in 1,342 healthy controls, 327 clearance subjects, 2,736 HBV-positive including 1,108 hepatocellular carcinoma (HCC) patients, using quantitative PCR. determined by sequencing. Multiplicative viral assessed multivariate logistic regression....
Objectives: Although patients with grade I and II endometrioid endometrial adenocarcinoma (EEA) are considered good prognosis, among them 15%-25% died in 5 years.It is still unknown whether integrating estrogen receptor (ER) progesterone (PR) into clinical risk stratification can help select high-risk I-II EEA.This study was to investigate the prognostic value of ER PR double negativity (ER/ loss) EEA, association between ER/PR loss The Cancer Genome Atlas (TCGA) classification.Methods: were...
Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well cancer. But the exact impact of IR on fertility-sparing treatment in hyperplasic disease is unclear. This investigated how affects atypical (EAH) patients. The 151 EAH patients received were retrospectively investigated. All high-dose progestin combined with hysteroscopy. Therapeutic effects evaluated by hysteroscopy every 3 months during treatment. median age 33.0 years old (range, 21-54...
To identify endotypes of osteoarthritis (OA) by a metabolomics analysis.Study participants included hip/knee OA patients and controls. Fasting plasma samples were metabolomically profiled. Common factor analysis K-means clustering applied to the data patients. Logistic regression was utilized most significant metabolites contributing endotypes. Clinical epidemiological factors examined in relation identified endotypes.Six hundred fifteen primary 237 controls included. Among 186 measured, 162...
Lipoprotein (LP) is a major component of the outer membrane bacteria in family Enterobacteriaceae. LP induces proinflammatory cytokine production macrophages and lethal shock LPS-responsive -nonresponsive mice. In this study, release from growing was investigated by immuno-dot blot analysis. An assay that could detect at levels as low 100 ng/ml developed. By using assay, significant were detected culture supernatants Escherichia coli cells. During mid-logarithmic growth, approximately 1 to...
Abstract Background Rapid identification and differentiation of mosquito-transmitted flaviviruses in acute-phase sera patients field-caught vector mosquitoes are important for the prediction prevention large-scale epidemics. Results We developed a flexible reverse-transcription loop-mediated isothermal amplification (RT-LAMP) unit detection dengue virus serotypes 1-4 (DENV1-4), Japanese encephalitis (JEV), West Nile (WNV). The efficiently amplified viral genomes specifically at wide ranges...
We aimed to determine the associations of genetic polymorphisms excision repair cross-complementation group 1 (ERCC1) rs11615, xeroderma pigmentosum D (XPD/ERCC2) rs13181, X-ray cross complementing (XRCC1) rs25487, XRCC3 rs1799794, and breast cancer susceptibility gene (BRCA1) rs1799966 from DNA pathway multiple drug resistance (MDR1/ABCB1) rs1045642 with response chemotherapy survival non-small cell lung (NSCLC) in a Chinese population.A total 352 NSCLC patients were enrolled evaluate six...
Abstract As indigenous malaria has decreased over recent decades, the increasing number of imported cases provided a new challenge for China. The proportion due to Plasmodium ovale increased during this time, and difference between P. curtisi wallikeri is importance. To better understand epidemiology differences two subspecies, information on in Henan Province was collected 2010–2017. We carried out descriptive study analyze prevalence, proportion, distribution, origin o. . It showed that...
Abstract Background: Body adiposity index (BAI), indirect method proposed to predict adiposity, was developed using Mexican Americans and very little data are available regarding its validation in Caucasian populations date. Objective: The study objectives were validate the BAI with dual‐energy X‐ray absorptiometry (DXA) body fat percentage (%BF), taking into consideration gender status. Design Methods: A total of 2,601 subjects (Male 662, Female 1939) from our Complex Diseases Newfoundland...