Walther Vogel
A5046649622- Prostate Cancer Treatment and Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Genetic Associations and Epidemiology
- Carcinogens and Genotoxicity Assessment
- Prenatal Screening and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- DNA and Nucleic Acid Chemistry
- Genetics and Neurodevelopmental Disorders
- Genomics and Chromatin Dynamics
- Genetic factors in colorectal cancer
- Nutrition, Genetics, and Disease
- Sexual Differentiation and Disorders
- BRCA gene mutations in cancer
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Trauma Management and Diagnosis
- RNA Research and Splicing
- Genetic diversity and population structure
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
The Netherlands Cancer Institute
2024
University Hospital Ulm
2007-2020
Universität Ulm
2007-2017
Praxis für Humangenetik
1975-2009
Brigham and Women's Hospital
2009
Cornell University
2009
Schmerzklinik Kiel
1975-2009
Universität Innsbruck
2005-2008
Innsbruck Medical University
2007-2008
Institute of Human Genetics
2002-2005
<h3>Abstract</h3> <h3>Objectives</h3> To develop and validate a genetic tool to predict age of onset aggressive prostate cancer (PCa) guide decisions who screen at what age. <h3>Design</h3> Analysis genotype, PCa status, select single nucleotide polymorphisms (SNPs) associated with diagnosis. These were incorporated into survival analysis estimate their effects on diagnosis (that is, not eligible for surveillance according National Comprehensive Cancer Network guidelines; any Gleason score...
Prostate cancer has a strong familial component but uncovering the molecular basis for inherited susceptibility this disease been challenging. Recently, rare, recurrent mutation (G84E) in HOXB13 was reported to be associated with prostate risk. Confirmation and characterization of finding is necessary potentially translate information clinic. To examine large international sample families, we genotyped 14 other SNPs or flanking 2,443 families recruited by International Consortium Cancer...
In a quality assessment project for endoscopic retrograde cholangiopancreatography (ERCP), initiated in 2006 by the Austrian Society of Gastroenterology and Hepatology, benchmark data were collected on voluntary basis. Results from individual participating centers, both academic community-based, compared with pooled data, intention that problems should be identified corrected order to improve patient care Austria. Success complication rates nonselected patients evaluated, especially regard...
Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We previously shown evidence for a strong association prostate (PrCa) risk rs2242652 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate genetic variation across this region PrCa, we performed fine-mapping analysis by genotyping 134 SNPs using custom Illumina iSelect array or Sequenom MassArray iPlex, followed...
Biglycan (PG-I, DS-PG-1, PG-S1) is a small cellular or pericellular matrix proteoglycan that closely related in structure to two other proteoglycans, decorin (PG-II, PG-S2, DS-PG2, PG-40) and fibromodulin. The core protein made up predominantly of series 11 tandem repeats appear have been used throughout evolution for protein-protein, protein-cell, cell-cell interactions. function biglycan unclear at this time, but it has shown bind transforming growth factor beta vitro. We cloned partially...
The micronucleus assay (MNT) in human lymphocytes is frequently used to assess chromosomal damage as a consequence of environmental mutagen exposure, the effect mutagens or search for reduced DNA repair capacity after mutagenic challenge. We have established an automated scoring procedure cytokinesis blocked MNT based on computerized image analysis (Metasystems Metafer 4 version 2.12). To evaluate results we reproducibility counts, dose–response curve γ-irradiation and ability system...
A technique is described for visualizing late-replicating regions by a Hoechst 33258-Giemsa-staining procedure combining the techniques of Latt (1973) and Perry Wolff (1974). The advantages are two-fold: distinct bands obtained many possible mistakes interpretation difficulties with autoradiography avoided. time sequence late-replication patterns (excepting C-group chromosomes) has been established in human fibroblasts adults, these results have compared three four different cell types from...
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We fine-mapped 64 GWAS regions known at the conclusion of iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases 26 274 controls European ancestry. detected evidence for multiple independent signals 16 regions, 12 which contained additional newly significant associations. A single signal comprising a spectrum correlated variation was observed 39 regions; 35...
An analysis of the pattern association acrocentric chromosomes with nonacrocentric in human lymphocyte metaphases was performed. This nonrandom respect to chromosome length and intrachromosomal distribution. There is a general preference for centric regions, most pronounced at proximal segments long arms 1, 9, 16, which interpreted reflect heterochromatin attraction during interphase. Comparison patterns homologous 1's differing regard size their heterochromatic regions corroborates this...