A5103076755- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Bladder and Urothelial Cancer Treatments
- Stroke Rehabilitation and Recovery
- Ureteral procedures and complications
- BRCA gene mutations in cancer
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Pelvic floor disorders treatments
- Healthcare Policy and Management
- Renal and Vascular Pathologies
- MRI in cancer diagnosis
- Acute Lymphoblastic Leukemia research
- Radiomics and Machine Learning in Medical Imaging
- Kidney Stones and Urolithiasis Treatments
- Genetic factors in colorectal cancer
- Urinary Tract Infections Management
- Epigenetics and DNA Methylation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Colorectal Cancer Screening and Detection
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
University of Michigan
2013-2025
University of North Carolina at Chapel Hill
2024-2025
Markey Cancer Center
2024
University of Kentucky
2014-2024
Michigan United
2023
North Manchester General Hospital
2023
Michigan Medicine
2020-2022
Grand Rapids Community College
2020-2021
Ann Arbor Center for Independent Living
2017-2020
Ypsilanti District Library
2020
Prostate cancer has a strong familial component but uncovering the molecular basis for inherited susceptibility this disease been challenging. Recently, rare, recurrent mutation (G84E) in HOXB13 was reported to be associated with prostate risk. Confirmation and characterization of finding is necessary potentially translate information clinic. To examine large international sample families, we genotyped 14 other SNPs or flanking 2,443 families recruited by International Consortium Cancer...
Irbesartan, a long acting selective angiotensin-1 receptor inhibitor, in Marfan syndrome might reduce aortic dilatation, which is associated with dissection and rupture. We aimed to determine the effects of irbesartan on rate dilatation children adults syndrome.We did placebo-controlled, double-blind randomised trial at 22 centres UK. Individuals aged 6-40 years clinically confirmed were eligible for inclusion. Study participants all given 75 mg open label once daily, then randomly assigned...
BACKGROUND Prostate cancer has a significant heritable component, and rare deleterious germline variants in certain genes can increase the risk of disease. The aim current study was to describe prevalence pathogenic cancer‐predisposing men with prostate at least 1 additional primary cancer. METHODS Using multigene panel, authors sequenced DNA from 102 who also met ≥1 following criteria: 1) age ≤55 years time diagnosis first malignancy; 2) tumor type or atypical presentation common tumor;...
Background Urinary continence after radical prostatectomy (RP) is an important determinant of patient quality life. Anatomic measures at prostate MRI have been previously associated with outcomes, but their predictive ability and interrater agreement are unclear in comprehensive clinical models. Purpose To evaluate the MRI-based anatomic measurements post-RP when combined multivariable Materials Methods In this retrospective cohort study, outcomes were evaluated men who underwent RP from...
Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary cancer. The histomorphologic and molecular features of cancers arising such carriers have not been studied. Here, we reviewed prostatectomy specimens from 23 G84E carriers, mapping total cancer burden by anatomically distinct focus evaluating morphologic features. We...
Purpose Tissue-based gene expression classifiers (GECs) may assist with management decisions in patients newly diagnosed prostate cancer. We sought to assess the current use of GEC tests and determine how test results are associated primary disease management. Methods In this observational study, localized cancer were tracked through Michigan Urological Surgery Improvement Collaborative registry. The utilization three GECs (Decipher Prostate Biopsy, Oncotype DX Prostate, Prolaris)...
Background: Effective interventions to lower blood pressure (BP) after stroke are needed, especially for vulnerable populations such as Black individuals and those with post-stroke disability. The TEAMS-BP trial is designed compare the effectiveness of two evidence-based among survivors uncontrolled BP. Methods: Telehealth Enhanced Assessment Management Stroke-BP (TEAMS-BP) compares Intensive Clinic (ICM, in-person medical management home BP monitoring via daily paper logs health promotion...
Background: Renal biopsies are uncommonly performed in horses and little is known about their diagnostic utility associated complication rate. Objective: To describe the techniques, rate, risk factors, histopathology results; as well evaluate safety of renal biopsy horse. Animals: One hundred forty‐six from which 151 were obtained. Animals ranged age 48 hours to 30 years. Methods: Multicenter retrospective study, with participation 14 institutions (1983–2009). Results: was a similar rate...
Prostate cancer is the most common non-skin and second leading cause of related mortality for men in United States. There strong empirical epidemiological evidence supporting a stronger role genetics early-onset prostate cancer. We performed genome-wide association scan Novel aspects this study include focus on disease (defined as with diagnosed before age 56 years) use publically available control genotype data from previous studies. found significant (p<5×10−8) variants at 8q24 11p15...
Background African Americans have both a higher incidence of prostate cancer and greater disease‐specific mortality compared with non‐Hispanic whites. Historically, the investigation contribution rare genetic variants to in American men has been hampered by low participation large studies, particularly those focused on early‐onset familial disease. Methods We sequenced 160 genes purported be involved carcinogenic pathways germline DNA samples collected from 96 diagnosed (≤55 years at...
Glycobiology research with Caenorhabditis elegans (C. elegans) has benefitted from the numerous genetic and cell biology tools available in this system. However, lack of a line relative inaccessibility C. somatic cells vivo have limited biochemical approaches model. Here we report that primary embryonic culture incorporate azido-sugar analogs N-acetylgalactosamine (GalNAc) N-acetylglucosamine (GlcNAc), labeled glycoproteins can be analyzed by mass spectrometry. By using metabolic labeling...
To determine the prevalence and clinical correlates of G84E mutation in homeobox transcription factor, or HOXB13, gene using DNA samples from 9559 men with prostate cancer undergoing radical prostatectomy.DNA treated prostatectomy at University Michigan John Hopkins were genotyped for this was confirmed by Sanger sequencing. The frequency distribution allele determined according to specific patient characteristics (family history, age diagnosis, pathological Gleason grade stage).Of patients,...
BACKGROUND Family history of prostate cancer is a well-recognized risk factor. Previous linkage studies have reported putative susceptibility locus at chromosome 17q21–22. SPOP (Speckle-type POZ protein) maps to the 17q21–22 candidate region and one most frequently mutated genes in sporadic cancers. METHODS We performed targeted next generation sequencing analyze 2009 exons from 202 on using 94 unrelated familial cases University Michigan Prostate Cancer Genetics Project (n = 54) Johns...
BACKGROUND Family history is a major risk factor for prostate cancer (PCa), suggesting genetic component to the disease. However, traditional linkage and association studies have failed fully elucidate underlying basis of familial PCa. METHODS Here, we use candidate gene approach identify potential PCa susceptibility variants in whole exome sequencing data from cases. Six hundred ninety-seven genes were identified based on function, location near known chromosome 17 signal, and/or previous...
While surgical excision remains the principal management strategy for clinical T1 renal masses (cT1RMs), rates of noninterventional approaches are not well known. Most single-institution and population-based series suggest below 10%.
Renal mass biopsy (RMB) has had limited and varied utilization to guide management of renal masses (RM). To evaluate RMB for newly diagnosed cT1 RMs across diverse practice types assess associations outcomes with RMB. MUSIC-KIDNEY commenced data collection in September 2017 all presenting patients a RM at 14 practices. Patients were assessed ≥120 d after initial evaluation. Demographics compared undergoing versus no Clinical demographic characteristics summarized by status using χ2 test...
We describe the establishment of Michigan Urological Surgery Improvement Collaborative-Kidney mass: Identifying and Defining Necessary Evaluation therapY (MUSIC-KIDNEY) to improve quality care that patients in receive for localized, 7 cm or smaller (T1) renal masses.The MUSIC-KIDNEY collaborative is comprised 45 urologists from 8 group practices. From June 2017 November 2018 surgeons collected data 821 with newly diagnosed T1 masses. Goals are reduce overall burden treatment masses...