A5072521749- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Ovarian cancer diagnosis and treatment
- DNA Repair Mechanisms
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Uterine Myomas and Treatments
- Colorectal and Anal Carcinomas
- Proteoglycans and glycosaminoglycans research
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Advances in Oncology and Radiotherapy
- Economic and Financial Impacts of Cancer
- Soft tissue tumors and treatment
- Clinical practice guidelines implementation
- Lymphoma Diagnosis and Treatment
- Interprofessional Education and Collaboration
- Glycosylation and Glycoproteins Research
- Palliative Care and End-of-Life Issues
Lund University
2016-2025
Copenhagen University Hospital
2013-2024
Skåne University Hospital
2010-2024
Amager Hospital
2021-2024
Region Västra Götaland
2018-2024
Hvidovre Hospital
2013-2022
Danish Cancer Society
2018-2022
University of Copenhagen
2010-2022
Innovation Skåne (Sweden)
2019
Regional Cancer Center
2017
Recent studies suggest that one or more genes on chromosome 5q21 are important for the development of colorectal cancers, particularly those associated with familial adenomatous polyposis (FAP). To facilitate identification from this locus, a portion region is tightly linked to FAP was cloned. Six contiguous stretches sequence (contigs) containing approximately 5.5 Mb DNA were isolated. Subclones these contigs used identify and position six genes, all which expressed in normal colonic...
Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), contribute to tumor development in patients with noninherited forms colorectal cancer. Two tightly linked FAP (MCC APC) were found be somatically altered tumors from sporadic cancer patients. One (APC) was also by point mutation germ line GS These data suggest than gene may neoplasia, mutations APC can cause both GS. The...
Recent studies have suggested the existence of a tumor suppressor gene located at chromosome region 5q21. DNA probes from this were used to study panel sporadic colorectal carcinomas. One these probes, cosmid 5.71, detected somatically rearranged restriction fragment in single tumor. Further analysis 5.71 revealed two regions that highly conserved rodent DNA. These sequences identify gene, MCC (mutated cancer), which encodes an 829-amino acid protein with short similarity G protein-coupled...
LBA125 Background: Colorectal cancer (CRC) affects 1.9 million individuals globally each year. Among patients with stage II-III CRC, 20-40% develop metastatic disease. Aspirin lowers the incidence of adenomas and CRC in high-risk patients. In addition, observational studies suggest that post-diagnosis aspirin treatment improves disease-free survival (DFS) unselected populations. Furthermore, retrospective findings indicate somatic PIK3CA mutations predict response, but requires validation...
Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary monitor effects tailored surveillance. In particular, patients Lynch syndrome, nonpolyposis (HNPCC), an increased risk develop at early age. The syndrome explained by germline mutations in DNA mismatch repair (MMR) genes, there a need diagnostic tools preselect genetic testing...
Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism. One-third STS metastasize current risk-stratification suboptimal, therefore, novel diagnostic prognostic markers would be clinically valuable. We assessed the value array-based gene expression profiles using 27 k cDNA microarrays in 177, mainly high-grade, 13 subtypes. Unsupervised analysis resulted two major clusters...
Case review and discussion at multidisciplinary team meetings (MDTMs) have evolved into standard practice in cancer care with the aim to provide evidence-based treatment recommendations. As a basis for work optimize MDTMs, we investigated participants' views on meeting function, including perceived benefits barriers. In cross-sectional study design, 244 health professionals from south Sweden rated MDTM structure these barriers reach recommendation. The top-ranked advantages MDTMs were...
Following the first case of acute respiratory syndrome coronavirus 2 (SARS-CoV-2, known as COVID-19) in Denmark at end February 2020, wide-spread social distancing was implemented and societ...
Abstract Cytogenetic analysis of short‐term cultures from 25 malignant fibrous histiocytomas (MFH) revealed clonal chromosome abnormalities in 17 tumors: ten storiform‐pleomorphic and seven myxoid MFH. Telomeric associations, rings, dicentric chromosomes were present 11 tumors cytogenetic signs gene amplification (homogeneously staining regions double minute chromosomes) four. The breakpoint distribution the numerous structural rearrangements was nonrandom. bands most frequently affected...
Immunohistochemical staining for mismatch repair proteins is efficient and widely used to identify defective tumors. The tumors typically show uniform widespread loss of MMR protein staining. We identified characterized colorectal cancers with alternative, heterogenous in order delineate expression patterns underlying mechanisms.Heterogenous that affected at least one the MLH1, PMS2, MSH2 MSH6 were 14 cancers. Based on alternative macro-dissected micro-dissected tumor areas separately...
Background and purpose Brain tumors represent a rare relatively uncharacterized tumor type in Lynch syndrome. Methods The national Danish Hereditary Nonpolyposis Colorectal Cancer Register was utilized to estimate the cumulative life‐time risk for brain syndrome, mismatch repair ( MMR ) status all available evaluated. Results Primary developed 41/288 families at median age of 41.5 (range 2–73) years. Biallelic gene mutations were linked development childhood. significantly higher (2.5%) MSH...
Multidisciplinary team (MDT) conferences have been introduced into standard cancer care, though evidence that it benefits the patient is weak. We used national Swedish Rectal Cancer Register to evaluate predictors for case discussion at a MDT conference and its impact on treatment.Of 6760 patients diagnosed with rectal in Sweden between 2007 2010, 78% were evaluated MDT. Factors influenced whether was discussed preoperative 4883 patients, of evaluation implementation radiotherapy 1043...