A5062457221- Kawasaki Disease and Coronary Complications
- Congenital Heart Disease Studies
- COVID-19 Impact on Reproduction
- Coronary Artery Anomalies
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Cardiovascular Issues in Pregnancy
- Respiratory viral infections research
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Conditions and Treatments
- Cardiac Structural Anomalies and Repair
- Immunodeficiency and Autoimmune Disorders
- Connective tissue disorders research
- Kidney Stones and Urolithiasis Treatments
- Cardiac pacing and defibrillation studies
- IgG4-Related and Inflammatory Diseases
- Porphyrin Metabolism and Disorders
- Vitamin D Research Studies
- Genetic Syndromes and Imprinting
- Child and Adolescent Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
Birmingham Children's Hospital
2015-2024
Birmingham Women’s and Children’s NHS Foundation Trust
2020-2022
Government of the United Kingdom
2020-2021
National Health Service
2014-2018
Society of Thoracic Surgeons
2014
Boston Children's Hospital
2010
Glenfield Hospital
2004
Children were relatively spared during COVID-19 pandemic. However, the recently reported hyperinflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome-"Paediatric Inflammatory Multisystem Syndrome-temporally associated SARS-CoV-2" (PIMS-TS) has caused concern. We describe cardiac findings short-term outcomes in children PIMS-TS at a tertiary children's hospital. Single-center observational study from 10th April to 9th May 2020. Data on ECG echocardiogram...
Background: The aim of the study was to document cardiovascular clinical findings, cardiac imaging, and laboratory markers in children presenting with novel multisystem inflammatory syndrome associated coronavirus disease 2019 (COVID-19) infection. Methods: This real-time internet-based survey has been endorsed by Association for European Paediatric Congenital Cardiologists Working Groups Cardiac Imaging Cardiovascular Intensive Care. Children 0 18 years age admitted a hospital between...
Irbesartan, a long acting selective angiotensin-1 receptor inhibitor, in Marfan syndrome might reduce aortic dilatation, which is associated with dissection and rupture. We aimed to determine the effects of irbesartan on rate dilatation children adults syndrome.We did placebo-controlled, double-blind randomised trial at 22 centres UK. Individuals aged 6-40 years clinically confirmed were eligible for inclusion. Study participants all given 75 mg open label once daily, then randomly assigned...
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed MIS-C patients had highly activated neutrophils, classical monocytes and memory CD8+ T-cells, with increased frequencies of B-cell plasmablasts double-negative B-cells. Post treatment samples from the same patients, taken during symptom resolution, identified recovery-associated features...
To measure the left and right ventricular myocardial velocities using tissue Doppler imaging (TDI) in first 24 h of life neonates.Left peak systolic (S'), early diastolic (E') late (A') were measured TDI alongside standard echocardiography (including atrioventricular flow, E). E/E' ratio was calculated for both ventricles.UK neonatal intensive care unit.43 neonates prospectively recruited into three groups: term (n=16), preterm (30-36 weeks, n=12) very (<30 n=15).Myocardial increased with...
Whilst hypocalcemic complications from vitamin D deficiency are considered rare in high-income countries, they highly prevalent among Black, Asian and Minority Ethnic (BAME) group with darker skin. To date, the extent of osteomalacia such infants their family members is unknown. Our aim was to investigate clinical, cardiac bone histomorphometric characteristics, matrix mineralization affected test for biochemical evidence osteomalacia. Three BAME origin (aged 5–6 months) presented acutely...
Background During the COVID-19 outbreak, reports have surfaced of children who present with features a multisystem inflammatory syndrome overlapping Kawasaki disease and toxic shock – Paediatric Inflammatory Multisystem Syndrome-temporally associated SARS-CoV-2 pandemic (PIMS-TS). Initial find that many are PCR-negative for SARS-CoV-2, so it is difficult to confirm whether this late complication viral infection in an age group largely spared worst consequences infection, or if reflects...
Abstract Coronavirus disease 2019 (COVID-19) has caused mild illness in children, until the emergence of novel hyperinflammatory condition paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory coronavirus 2 (SARS-CoV-2) (PIMS-TS). PIMS-TS is thought to be a post-SARS-CoV-2 immune dysregulation excessive cytokine release. We studied 25 hydroxyvitamin D (25OHD) concentrations children PIMS-TS, admitted tertiary hospital UK, due its postulated role...
Background: The aim of the study was to document cardiovascular clinical findings, cardiac imaging and laboratory markers in children presenting with novel multisystemic inflammatory syndrome associated COVID-19. Methods: A real-time internet based survey sent via member mailing database for Association European Paediatric Congenital Cardiologists (AEPC) working groups Cardiac Imaging Cardiovascular Intensive Care member. Inclusion criteria 0-18 years admitted hospital between March 1 June...
Although cardiologists were 'late-comers' to the multidisciplinary team-contributing complex care of patients with Duchenne muscular dystrophy (DMD), they now recognise importance systematic cardiac surveillance and timely therapy prolonged survival in DMD. Empirical deployment cardioactive medications has already improved outcomes, but evidence base for clinical decision making is weak. Fundamental questions remain as whether prophylactic justified convincingly superior prompt same...
Abstract Objective: To assess myocardial function in preterm infants with different degrees of ductal patency the first week life using tissue Doppler imaging. Study design: Infants <30 weeks gestation underwent echocardiography on day 3. A total 72 were recruited into study and categorised three groups (i) haemodyamically significant ductus arteriosus, (ii) patent arteriosus (iii) no arteriosus. Those haemodynamically treated indometacin was repeated after 48–72 hours following...
Abstract Objective : To analyze the safety and clinical impact of interventional cardiac catheter procedures in management early postoperative problems after completion an extracardiac Fontan procedure. Background The mortality procedure has consistently decreased over last decade. role catheterization to address this setting not been studied systematically. Methods Over a 9.7‐year period, 289 patients underwent fenestrated with two deaths (0.7%) takedown four (1.4%). Twenty‐seven (9.3%) 32...
This study determined cardiovascular impairment in young children with obstructive respiratory disease who were assessed using the opening interrupter technique (RINT).This pilot enrolled 41 had been referred to pulmonology and allergology specialists at University of Catania, Italy, from March July 2017: 23 (mean age 4.13 ± 0.62 years) chronic coughs wheezing 18 controls 4.27 0.66 chest disease, but otherwise healthy. Airway resistance was evaluated RINT cardiac function by studying...
Since 2008, orally administered propranolol has rapidly gained acceptance as the preferred therapy for haemangiomas, and is usually initiated by ophthalmologists, dermatologists or plastic surgeons who do not routinely use any other indication. During initial years when experience was limited, most healthcare professionals justifiably adopted a cautious approach initiating monitoring treatment. A consensus recommendation from American Society of Dermatologists suggests routine observation,...
Background: It has been suggested that children and infants can develop multisystem inflammatory syndrome in (MIS-C) response to a SARS-CoV-2 infection Black are overrepresented among cases. The aim of the current study was quantify association between Black, Asian, or other non-White genetic background COVID-19-related MIS-C infants. Methods: Eight different research groups contributed cases MIS-C, potentially related infection. Several sensitivity analyses were performed, including...
COVID-19 has caused significant worldwide morbidity and mortality. Congenital heart disease (CHD) is likely to increase vulnerability understanding the predictors of adverse outcomes key optimising care.
Rhabdomyolysis secondary to bacterial infection has only rarely been investigated, and there are case reports of the same mainly in adults. This article describes first reported rhabdomyolysis a child Staphylococcus aureus endocarditis. A 12-year-old presented with myalgia, pyrexia dark urine was found have infective endocarditis due S. aureus.