A5061420871- Epigenetics and DNA Methylation
- Renal and related cancers
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Hormonal Regulation and Hypertension
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Stress Responses and Cortisol
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Galectins and Cancer Biology
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Caveolin-1 and cellular processes
- Prostate Cancer Diagnosis and Treatment
- Bone and Dental Protein Studies
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Testicular diseases and treatments
- Birth, Development, and Health
Medizinische Hochschule Hannover
2013-2023
Klinik und Poliklinik für Urologie
1993-2007
Fibronectin 1 (FN1) is a glycoprotein involved in cellular adhesion and migration processes. The aim of this study was to elucidate the role FN1 development renal cell cancer (RCC) determine prognostic relevance for optimal clinical management.212 tissue samples (109 RCC, 86 corresponding tissues from adjacent normal 17 oncocytomas) were collected patients undergoing surgery tumors subjected total RNA extraction. Detection mRNA expression performed using quantitative real time PCR, three...
A prostate cancer (PCa) biomarker with improved specificity relative to PSA is a public health priority. Hypermethylated DNA can be detected in body fluids from PCa patients and may useful biomarker, although clinical performance varies between studies. We investigated the of candidate methylation biomarkers identified through genome-wide search.Real-time PCR was used measure four biomarkers: GSTP1 three previously unreported candidates associated genes RASSF2, HIST1H4K, TFAP2E sodium...
Whether methylation of the microRNA (mir)-124-3 CpG island is relevance for clinical course a solid cancer and whether it shows association with clinicopathology or survival patients renal cell (RCC) not known as yet.In cross-sectional study, relative mir-124-3 was measured in 111 RCC samples 77 paired normal appearing tissues using quantitative methyl-specific PCR. Results were statistically compared tumour histology, clinicopathological parameters disease recurrence.We found...
Caveolae play a significant role in disease phenotypes such as cancer, diabetes, bladder dysfunction, and muscular dystrophy. The aim of this study was to elucidate the caveolin-1 (CAV1) protein expression renal cell cancer (RCC) determine its potential prognostic relevance.289 clear RCC tissue specimens were collected from patients undergoing surgery for tumors. Both cytoplasmic membranous CAV1 determined by immunohistochemistry correlated with clinical variables. Survival analysis carried...
VEGF-targeted therapy increases both the progression-free (PFS) and overall survival (OS) of patients with metastasized renal cell cancer (mRCC). Identification molecular phenotypes RCC could improve risk-stratification prediction clinical disease course. We investigated whether gene-specific DNA hypermethylation can predict PFS OS among undergoing anti-VEGF-based therapy. Primary tumor tissues from 18 receiving targeted were examined retrospectively using quantitative methylation-specific...
Neurofilament Heavy polypeptid (NEFH) belongs to the group of type IV intermediate filament proteins. DNA methylation NEFH promoter and loss expression have previously been shown activate AKT/β-catenin pathway in tumor cells. When identifying hypermethylation CpG island (CGI) renal cell cancer (RCC) we asked whether could provide clinical or prognostic information for RCC and/or predict therapy response patients with metastatic (mRCC) undergoing antiangiogenic therapy. Relative CGI was...
Altered expression or loss of function Galectin-3 (Gal-3) was suggested to be involved in the pathogenesis and progression various human cancer entities. The aim present study is determine Gal-3 prostate tissue emerging from a benign malignant, beginning hormone-sensitive finally hormone-refractory status further elucidate role this carbohydrate-binding protein for and/or malignant prostatic disease.Five hundred eighty three samples tumor adjacent benign, histologically intra-prostatic...
Epigenetic silencing of the RAS association domain family 1A (RASSF1A) tumor suppressor gene promoter has been demonstrated in renal cell carcinoma (RCC) as a result hypermethylation. Contradictory results have reported for RASSF1A methylation normal kidney, thus it is not clear whether significant difference between and cells kidney exists. Moreover, expression characterized tumors or tissue yet.Using combined bisulfite restriction analysis (COBRA) we compared 90 paired samples obtained...
Loss of the secreted Fzd-related protein 1 (SFRP1) and concurrent alteration SFRP1/WNT pathway are frequently observed in human cancers such as renal cell cancer (RCC). Whether methylation a SFRP1 CpG island locus normal solid tissues is associated with increased tissue specific risk has not been determined to date. Here we measure attributable DNA tissue. Pyrosequencing bisulfite treated was used for case-control study including 120 normal-appearing autopsy specimens 72 obtained from tumor...
Age, adiposity, and smoking are risk factors for the development of renal cell carcinoma. Hypermethylation RAS association domain family 1A gene (RASSF1A) promoter belongs to most frequently detected epigenetic alterations in human cancers including RASSF1A is functionally involved cycle control normal cells depletion promotes a number cellular changes increasing neoplastic growth. We investigated hypothesis that age, modulated by adiposity anthracosis as surrogate smoking, predictor...
The evolutionarily conserved Notch signalling pathway regulates multiple developmental processes in a wide variety of organisms. One critical posttranslational modification for its function vivo is the addition O-linked fucose residues by protein O-fucosyltransferase 1 (POFUT1). In addition, POFUT1 acts as chaperone and required trafficking. Mouse embryos lacking die with phenotype indicative global inactivation signalling. on can serve substrates further sugar Fringe (FNG) proteins....
The p27Kip1 gene has been identified as inductor of cell cycle arrest at the G1 checkpoint to prevent entry somatic cells into S phase when substantial DNA damage occurred. It suggested that decreased expression protein may contribute development human malignancies due loss critical antiproliferative mechanisms. In present study, 95 specimens (T1–T4) from randomly selected patients undergoing radical prostatectomy Urological Department Hannover University (82 patients) well in Josef Hospital...
GATA5 CpG island (CGI) methylation and transcriptional inactivation is involved in colorectal gastric cancer. Whether DNA of affects clinical pathology still unclear. In the present study, we analysed, for first time, CGI RCC its association with clinicopathological parameters progression-free survival patients. We show time hypermethylation RCC. Moreover, found out that increased statistically associated status metastasis, progressive disease shortened survival. The study underline...
To investigate galectin-8 expression patterns in normal urothelium and bladder cancer specimens to elucidate its prognostic value.162 samples of non-muscle-invasive transitional cell carcinoma, 25 muscle-invasive carcinoma 10 were investigated by immunohistochemistry using tissue microarrays. Complete patient tumor characteristics compared with staining patterns. The likelihood recurrence progression was analyzed based on a 3-year follow-up.Loss associated the univariate (p < 0.05)...