A5100405429- Tracheal and airway disorders
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Cancer Studies
- Dysphagia Assessment and Management
- Tissue Engineering and Regenerative Medicine
- Esophageal and GI Pathology
- Voice and Speech Disorders
- Healthcare professionals’ stress and burnout
- Mesenchymal stem cell research
- Reconstructive Facial Surgery Techniques
- Trauma Management and Diagnosis
- Electrospun Nanofibers in Biomedical Applications
- Innovations in Medical Education
- Head and Neck Anomalies
- Head and Neck Surgical Oncology
- Nanoplatforms for cancer theranostics
- Vascular Malformations and Hemangiomas
- Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Peptidase Inhibition and Analysis
- Diversity and Career in Medicine
- Liver physiology and pathology
- Thyroid and Parathyroid Surgery
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
First People's Hospital of Chongqing
2025
National League for Nursing
2024
University of North Carolina at Charlotte
2024
University of North Carolina at Chapel Hill
2022-2024
First Hospital of Jiaxing
2024
Lanzhou University
2024
First Hospital of Lanzhou University
2024
Jiaxing University
2024
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head neck squamous cell carcinoma (HNSCC) is largely different, little known about the anti-tumor mechanism tumor-infiltrated exhausted CD8 + T cells (Tex) in HNSCC. We performed cell-level multi-omics sequencing on HNSCC samples to decipher multi-dimensional characteristics Tex cells. A proliferative cluster (P-Tex) which was beneficial outcomes patients with HPV-positive identified. Interestingly, P-Tex...
Disaster is a serious public health issue. Health professionals and community residents are main players in disaster responses but their knowledge levels of medicine not readily available. This study aimed to evaluate training needs among potential responders presented necessity popularize education.A self-reporting questionnaire survey on level was conducted Shanghai, China, 2012. A total randomly selected 547 professionals, 456 medical students, 1,526 local provided intact information. The...
BACKGROUND: Chat Generative Pre-Trained Transformer (ChatGPT) has been tested and passed various high-level examinations. However, it not on an examination such as the American Board of Anesthesiology (ABA) Standardized Oral Examination (SOE). The SOE is designed to assess higher-level competencies, judgment, organization, adaptability unexpected clinical changes, presentation information. METHODS: Four anesthesiology fellows were examined 2 sample ABA SOEs. Their answers compared those...
ABSTRACT Background This study aims to report and evaluate the efficacy of using a novel submental flap for addressing laryngeal stenosis. Methods involved patients with glottic supraglottic stenosis following horizontal/vertical partial laryngectomy who were refractory repeated interventions. Kaplan–Meier curves used demonstrate decannulation, Mantel‐Cox Log‐rank test was compare rate difference in quality‐of‐life subgroup analysis. Results The average follow‐up time 30.04 ± 10.60 all...
<title>Abstract</title> <bold>Objective</bold> To investigate a rare adult case of choroid plexus carcinoma (CPC), with focus on identifying genetic variations and their implications for prognosis treatment selection. <bold>Methods</bold> The patient was diagnosed Magnetic Resonance Imaging (MRI) imaging histopathological features. Next-generation sequencing (NGS) conducted to identify aberrations. Expression FGFR2 FGF19/FGF3/FGF4/CCND1 (11q13 locus genes) identified in our were further...
In the present study, we aimed to determine whether combination of aggregate culture and decellularized liver scaffolds (DLSs) promoted hepatic differentiation murine bone marrow-derived mesenchymal stem cells (BM-MSCs) into high yields mature hepatocytes in vitro. Four culturing methods for [single cell (2D), spheroids (3D), 2D + DLS 3D DLS] were studied. To stages MSCs, RT-qPCR hepatocyte genes, immunostaining markers, functional analyses all performed. Compared with other groups,...
Whole-organ engineering is emerging as an alternative source for xenotransplantation in end-stage diseases. Utilization of decellularized whole lung scaffolds created by detergent perfusion effective strategy organ replacement. In the current study, we attempted to decellularize porcine lungs generate optimal and reproducible matrix future clinical use. Porcine were via various detergents (sodium dodecyl sulfate (SDS)/Triton X-100, sodium lauryl ether (SLES)/Triton dextrose/SDS/Triton X-100...
An individualized, tissue-engineered liver suitable for transplanting into a patient with disease would be of great benefit to the and healthcare system. The possess functions original healthy organ. Two fields study, (i) using decellularized tissue as cell scaffolding, (ii) stem differentiation functional cells, are coming together make this concept feasible. scaffolds (DLS) can interact cells promote signal transduction three-dimensional (3D) aggregations maintain phenotypes improve after...
6073 Background: For patients with locally advanced head and neck squamous cell carcinoma (HNSCC), even receiving surgery adjuvant radiotherapy or chemoradiotherapy, those remain at high risk of recurrence metastasis. Neoadjuvant immunotherapy has been used in HNSCC, but provides only modest pathological response. Given single agent activity unique mechanism action immune checkpoint inhibitors epidermal growth factor receptor (EGFR) tyrosine kinase (TKIs), we aimed to evaluate the antitumour...
Rationale: Ganglioneuroblastoma is usually located in the adrenal gland, retroperitoneal ganglia, or posterior mediastinum, but rarely occurs parapharyngeal space. Patient concerns: A 4-year-old girl presented with complaint of progressive inspiratory dyspnea and dysphagia, accompanying left-side Horner's syndrome. Diagnose: Computed tomography (CT) scan revealed a giant mass irregular low density left oropharyngeal pharyngeal wall. The carotid artery sheath was pushed to right. After...
Abstract Background Simultaneous tracheal and esophageal reconstruction after tumor resection is a great challenge. Here we present an innovative operative technique to simultaneously reconstruct defects, in which free posterior tibial artery perforator flap was made into bipaddled cover both defects. Methods A utilized conduct simultaneous for 72‐year‐old female patient with papillary thyroid carcinoma massive trachea esophagus invasion, who underwent radical resection. Results Satisfactory...
Genetic predisposition, in addition to smoking, is known play a key role susceptibility chronic obstructive pulmonary disease (COPD). Several candidate genes have been proposed for COPD, including surfactant protein B (SFTPB). However, large studies populations with different ethnic backgrounds and environments are required clarify the of SFTPB COPD.We investigated association polymorphisms COPD lung function Chinese Han population.Four single nucleotide (SNPs) gene were genotyped 680...
Stem cell‑based therapy serves a key role in clinical treatments, and mesenchymal stem cells (MSCs) have been widely used tumor trials. In the present study, MSCs were isolated from umbilical cord (UC) co‑cultured with lung cancer cell line H1299. The effects of UC‑derived (UCMSCs) on H1299 invasion proliferation evaluated using Matrigel‑based Transwell assay CCK8 assay, respectively. Apoptosis cycle progression among detected by flow cytometry, kinase expression was western blotting....
Cell-based approaches, including hepatocyte transplantation and tissue-engineered livers, offer promising alternatives are expected to help support patients with liver diseases until or recovery via regeneration of the damaged liver. However, success cell therapies remains dependent on how well cells accepted after is directly related their degree immunogenicity. In this study, hepatic differentiation human umbilical cord mesenchymal stem (hUC-MSCs) was induced in traditional monolayer (2D)...
Photodynamic therapy has emerged as a recognized anti-tumor treatment involving three fundamental elements: photosensitizers, light, and reactive oxygen species. Enhancing the effectiveness of photosensitizers remains primary avenue for improving biological therapeutic outcomes PDT. Through generations development, HPPH is 2-(1-hexyloxyethyl)-2-devinyl derivative pyropheophorbide-α, representing second-generation photosensitizer already undergoing clinical trials various tumors. The...