A5004213682- Genetic Associations and Epidemiology
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- Cardiac Health and Mental Health
- Chronic Disease Management Strategies
- Tryptophan and brain disorders
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Optimism, Hope, and Well-being
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- Urinary Tract Infections Management
- Advanced Sensor and Energy Harvesting Materials
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Alcohol Consumption and Health Effects
- Adolescent and Pediatric Healthcare
- Genomics and Phylogenetic Studies
- Health disparities and outcomes
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Nutritional Studies and Diet
West China Medical Center of Sichuan University
2020-2025
Sichuan University
2020-2025
Qinghai University
2024-2025
West China Hospital of Sichuan University
2022-2023
Chengdu University
2023
It remains unclear if patients with allergic rhinitis (AR) and/or asthma are susceptible to corona virus disease 2019 (COVID-19) infection, severity, and mortality.To investigate the role of AR in COVID-19 mortality, assess whether long-term medications affected outcomes COVID-19.Demographic clinical data 70,557 adult participants completed SARS-CoV-2 testing between March 16 December 31, 2020, UK Biobank were analyzed. The rates hospitalization, mortality relation pre-existing assessed...
Piwi-interacting RNAs are a type of small noncoding RNA that have various functions. piRBase is manually curated resource focused on assisting piRNA functional analysis. release v3.0 committed to providing more comprehensive related information. The latest covers >181 million unique sequences, including 440 datasets from 44 species. More disease-related piRNAs and targets been collected displayed. regulatory relationships between visualized. In addition the reuse expansion content in...
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head neck squamous cell carcinoma (HNSCC) is largely different, little known about the anti-tumor mechanism tumor-infiltrated exhausted CD8 + T cells (Tex) in HNSCC. We performed cell-level multi-omics sequencing on HNSCC samples to decipher multi-dimensional characteristics Tex cells. A proliferative cluster (P-Tex) which was beneficial outcomes patients with HPV-positive identified. Interestingly, P-Tex...
Psychiatric disorders have been reported to influence many health outcomes, but evidence about their impact on chronic kidney disease (CKD) has not fully explored, as well possible mechanisms implicated are still unclear. Four hundred forty-one thousand eight ninety-three participants from UK Biobank were included in this study. To assess the association between psychiatric mainly including depression, anxiety, stress-related disorders, substance misuse psychotic disorder, and CKD, a Cox...
The association between hyperuricemia/gout with cardiovascular diseases (CVD) have been investigated. However, whether the magnitude of associations differs hyperuricemia and gout, causality these associations, remains inconclusive.Based on UK Biobank, we conducted a cohort analysis including 431,967 participants, who were categorized as hyperuricemia, normal groups at recruitment, followed up for CVD until December 2019. phenotypic was estimated by Cox regression, adjusting multiple...
Habitual coffee consumption has been associated with multiple health benefits. A comprehensive analysis of disease trajectory and comorbidity networks in relation to is, however, currently lacking. We aimed comprehensively examine the outcomes habitual consumption, through clarifying its networks. Based on UK Biobank cohort, we included 395,539 individuals available information intake collected at recruitment between 2006 2010. These were categorized as having low (<1 cup per day), moderate...
An increased susceptibility to COVID-19 has been suggested for individuals with neurodegenerative diseases, but data are scarce from longitudinal studies.In this community-based cohort study, we included 96,275 participants of the UK Biobank who had available SARS-CoV-2 test results in Public Health England. Of these, 2617 a clinical diagnosis diseases inpatient hospital before outbreak (defined as January 31st, 2020), while remaining constituted reference group. We then followed both groups...
Whether a genetic predisposition to psychiatric disorders is associated with coronavirus disease 2019 (COVID-19) unknown.Our analytic sample consisted of 287,123 white British participants in UK Biobank who were alive on 31 January 2020. We performed genome-wide association study (GWAS) analysis for each disorder (substance misuse, depression, anxiety, psychotic disorder, and stress-related disorders) randomly selected half the population ("base dataset"). For other ("target dataset"),...
The rate of bile duct injury in laparoscopic cholecystectomy (LC) continues to be high due low critical view safety (CVS) achievement and the absence an effective quality control system. development intelligent system enables automatic LC surgery and, eventually, mitigation injury. This study aims develop surgical for using evaluate videos investigate factors associated with CVS achievement.SurgSmart, capable recognizing phases, disease severity, division action, automatically, was developed...
Introduction The initial acquisition and subsequent development of the microbiota in early life is crucial to future health. Cesarean-section (CS) birth considered affect microbial transmission from mother infant. Methods In this study, we collected fecal samples 34 CS infants their mothers West China Second Hospital, Sichuan University assess developmental trajectory infants. We explored mother-infant gut microbiome via comparison with corresponding Finnish data. Results Metagenomic...
Abstract Background: Chronic kidney disease (CKD) is a global health issue, with renal fibrosis being common pathway in CKD development. Histone modification plays crucial roles transcriptional regulation, but their pathological functions and mechanisms are not well understood. Methods: We utilized chromatin immunoprecipitation next-generation DNA sequencing (ChIP-seq) RNA-seq to evaluate the states of H3 lysine 27 acetylation (H3K27ac) 4 trimethylation (H3K4me3) mice. identified epigenetic...
Abstract Phosphorylated proteins in human sweat are found to be closely associated with neurodegenerative diseases, including Alzheimer's disease. Real‐time, non‐invasive detection of changes the types and levels phosphorylated is significant clinical value for prevention diagnosis these diseases. This research introduces an electrochemical sensor based on situ‐grown interpenetrating network structure UiO‐66‐NH 2 /MWCNTs‐OH, specifically designed detecting sweat. The tested common...
<title>Abstract</title> Sepsis is a life-threatening disease and among the most common cause of death, which influence series following medical conditions. A comprehensive analysis cross-talks with temporary order trajectory or led to death sepsis remains unclear. By using data from population-based UK Biobank, 8647 septic patients matching 86386 controls without were included. Individuals followed-up 1 month after index date until end 2019 linkage inpatient records registers. Then...
Abstract This study aimed to determine the association between serum uric acid (sUA) and nonalcoholic fatty liver disease (NAFLD) in nonobese postmenopausal women. A total of 4323 female individuals over 18 years age participated this cross-sectional study. The subjects were divided into four groups according menopause status body mass index. sUA quartiles population categorized as follows: Q1 ≤ 230 mmol/L, Q2: 231–270 Q3: 271–310 mmol/L Q4: ≥ 311 mmol/L. presence or absence NAFLD was...
Abstract Background The outbreak of COVID-19 generated severe emotional reactions, and restricted mobility was a crucial measure to reduce the spread virus. This study describes changes in public reactions patterns Chinese population during outbreak. Methods We collected data on response through Weibo, Twitter, between 1st January 31st March 2020. Using anonymized location-tracking information, we analyzed daily approximately 90% Sichuan residents. Results There were three distinct phases...
Next generation sequencing is a powerful technology whose application in entire RNA populations (RNA-Seq) of food-borne pathogens will provide valuable insights. A problem unique to prokaryotic RNA-Seq removal ribosomal RNA. Unlike eukaryotic messenger (mRNA), bacterial mRNA species are devoid polyadenylation at the 3’-end and thus approach affinity enrichment using oligo-dT probes not an option. Among several approaches enriching molecules, (rRNA) by subtractive hybridization has been...
Preterm birth is the leading cause of perinatal morbidity and mortality. Despite evidence shows that imbalances in maternal microbiome associates to risk preterm birth, mechanisms underlying association between a perturbed microbiota remain poorly understood.Applying shotgun metagenomic analysis on 80 gut microbiotas 43 mothers, we analyzed taxonomic composition metabolic function microbial communities term mothers.Gut mothers delivering prematurely showed decreased alpha diversity underwent...
Objectives Given the role of intraocular pressure in glaucoma, patient’s sleeping pattern might contribute to development and progression glaucoma. We performed a study understand association between sleep behaviours Design Our was prospective cohort study. Setting This UK Biobank. Self-reported data on five were collected using questionnaire at baseline. identified four patterns based cluster analysis behaviours. Participants In Biobank, 409 053 participants recruited 2006 2010 followed for...