A5003739931- Osteoarthritis Treatment and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Eating Disorders and Behaviors
- Nutrition and Health in Aging
- Inflammatory mediators and NSAID effects
- Hepatitis B Virus Studies
- Biochemical Analysis and Sensing Techniques
- Body Composition Measurement Techniques
- Cervical Cancer and HPV Research
- Macrophage Migration Inhibitory Factor
- Rheumatoid Arthritis Research and Therapies
- Immunotherapy and Immune Responses
- Muscle metabolism and nutrition
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Obesity and Health Practices
- Retinoids in leukemia and cellular processes
- Magnesium in Health and Disease
- Parathyroid Disorders and Treatments
Shenyang Center for Disease Control and Prevention
2024-2025
Criminal Investigation Police University of China
2024-2025
Henan University of Technology
2025
GW Medical Faculty Associates
2025
George Washington University
2025
Memorial University of Newfoundland
2015-2024
Shanghai University of International Business and Economics
2024
China Medical University
2006-2021
First Hospital of China Medical University
2006-2021
Memorial
2020
Background ‘Food addiction’ shares a similar neurobiological and behavioral framework with substance addiction. However whether, to what degree, ‘food contributes obesity in the general population is unknown. Objectives assess 1) prevalence of Newfoundland population; 2) if clinical symptom counts were significantly correlated body composition measurements; 3) food addicts more obese than controls, 4) macronutrient intakes are associated addiction’. Design A total 652 adults (415 women, 237...
Objectives To identify metabolic markers that can classify patients with osteoarthritis (OA) into subgroups. Design A case-only study design was utilised. Participants Patients were recruited from those who underwent total knee or hip replacement surgery due to primary OA between November 2011 and December 2013 in St. Clare's Mercy Hospital Health Science Centre General John's, capital of Newfoundland Labrador (NL), Canada. 38 men 42 women included the study. The mean age 65.2±8.7 years....
Alteration of extracellular calcium concentration may be involved in glucose metabolism a number pathways. The present study was designed to investigate the relationship between total serum and 1) fasting glucose, 2) insulin, 3) insulin resistance, 4) beta-cell function 1,182 healthy subjects from province Newfoundland Labrador, Canada. All variables were log10 transformed, confounding factors including age, trunk fat percentage, phosphorus, magnesium, 25-OH vitamin D, parathyroid hormone...
Although BMI is the most widely used measure of obesity, debate still exists on how accurately defines obesity. In this study, adiposity status defined by and dual‐energy X‐ray absorptiometry (DXA) was compared in a large population to evaluate accuracy BMI. A total 1,691 adult volunteers from Newfoundland Labrador participated study. body fat percentage (%BF) were measured for all subjects following 12‐h fasting period. Subjects categorized as underweight (UW), normal weight (NW),...
Nearly one-third of obese (OB) people are reported to be metabolically healthy based on BMI criteria. It is unknown whether this holds true when more accurate adiposity measurements applied such as dual-energy X-ray absorptiometry (DXA). We compared differences in the prevalence cardiometabolic abnormalities among groups classified using vs. DXA A total 1,907 adult volunteers from Newfoundland and Labrador participated. body fat percentage (%BF; measured DXA) were following a 12-h fasting...
Abstract Background The Food- Frequency Questionnaire (FFQ) is a dietary assessment tool frequently used in large-scale nutritional epidemiology studies. goal of the present study to validate self-administered version Hawaii FFQ modified for use general adult population Newfoundland and Labrador (NL). Methods Over one year period, 195 randomly selected adults completed four 24-hour recalls (24-HDRs) by telephone subsequent FFQ. Estimates energy nutrients derived from 24-HDRs FFQs were...
Background Magnesium plays a role in glucose and insulin homeostasis evidence suggests that magnesium intake is associated with resistance (IR). However, data inconsistent most studies have not adequately controlled for critical confounding factors. Objective The study investigated the association between IR normal-weight (NW), overweight (OW) obese (OB) along pre- post- menopausal women. Design A total of 2295 subjects (590 men 1705 women) were recruited from CODING study. Dietary was...
Objective. To identify novel biomarker(s) for predicting advanced knee OA. Methods. Study participants were derived from the Newfoundland Osteoarthritis and Tasmania Older Adult Cohort Study. All OA cases patients who underwent total replacement (TKR) due to primary Metabolic profiling was performed on fasting plasma. Four thousand eighteen plasma metabolite ratios that highly correlated with in SF our previous study generated as surrogates joint metabolism. Results. The discovery cohort...
Background Choline is an essential nutrient and betaine osmolyte methyl donor. Both are important to maintain health including adequate lipid metabolism. Supplementation of dietary choline increase muscle mass reduce body fat in animals. However, little data available regarding the role on composition humans. Objective To investigate association between intakes with a large population based cross-sectional study. Design A total 3214 subjects from CODING (Complex Disease Newfoundland...
The objective of this study was to determine how a high-intensity circuit-training (HICT) program affects key physiological health markers in sedentary obese men. Eight (body fat percentage<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mo>></mml:mo><mml:mn>26</mml:mn></mml:mrow></mml:math>%) males completed four-week HICT program, consisting three 30-minute exercise sessions per week, for total 6 hours exercise. Participants’ heart rate (HR), blood...
The concept of food addiction (FA) is a potentially important contributing factor to the development obesity in general population; however, little known about hormonal and dietary differences between with without FA. Therefore, aim our study was explore potential biomarkers, including various hormones neuropeptides, which regulate appetite metabolism, components that could differentiate Of 737 adults recruited from Newfoundland population, 58 food-addicted non-food-addicted overweight/obese...
Metabolic abnormalities are more associated with central obesity than peripheral obesity, but the underlying mechanisms largely unknown. The present study was to identify serum metabolic biomarkers which distinguish metabolically unhealthy centrally obese (MUCO) from healthy peripherally (MHPO) individuals.A two-stage case-control design employed. In discovery stage, 20 individuals (10 MHPO and 10 MUCO) were included in following validation 79 (20 normal weight (NW), 30 MHPO, 29 utilized....
Objective. To investigate the relationship between plasma and synovial fluid (SF) metabolite concentrations in patients with osteoarthritis (OA). Methods. Blood SF samples were collected from primary knee OA undergoing total arthroplasty. Metabolic profiling was performed by electrospray ionization tandem mass spectrometry using AbsoluteIDQ kit. The yielded 168 concentrations. Correlation analysis done on absolute as well concentration ratios Spearman’s rank correlation (ρ) method. Results....
Selenium (Se) is a trace element which plays an important role in adipocyte hypertrophy and adipogenesis. Some studies suggest that variations serum Se may be associated with obesity. However, there are few examining the relationship between dietary obesity, findings inconsistent. We aimed to investigate association intake panel of obesity measurements systematic control major confounding factors. A total 3214 subjects participated study. Dietary was determined from Willett food frequency...
Background . Whether there is heterogeneity in the development of BMI from middle-age onward still unknown. The primary aim this study to analyze long-term obesity and how trajectories are associated with health outcomes midlife. Methods Latent Class Growth Modelling was used capture changes over time. In study, 3070 individuals National Population Health Survey (NPHS), aged 40–55 years at baseline, were included. Results Four trajectory groups, “Normal-Stable” (N-S), “Overweight-Stable”...
Background: We aimed to study the relationships between serum Trimethylamine N-oxide (TMAO) and L-carnitine levels with metabolic syndrome profiles, including obesity, blood pressure, lipids, glucose insulin resistance (IR)-related index in humans. Methods: Cross-sectional was performed 1081 subjects from CODING Newfoundland. Serum TMAO were quantified by LC-MS/MS. Metabolic markers measured all using fasting samples. Partial correlation linear regression analysis employed after systematicly...