A5074647962- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Genital Health and Disease
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Nutrition and Health in Aging
- Tryptophan and brain disorders
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- Galectins and Cancer Biology
- Protease and Inhibitor Mechanisms
- Telomeres, Telomerase, and Senescence
- Advanced Proteomics Techniques and Applications
- Frailty in Older Adults
- NF-κB Signaling Pathways
Huashan Hospital
2017-2025
Fudan University
2015-2025
Lanzhou University Second Hospital
2025
Lanzhou University
2025
Huadong Hospital
2017-2025
First Affiliated Hospital of Harbin Medical University
2020-2025
Peking University
2014-2024
Peking University People's Hospital
2013-2024
Shenzhen Institutes of Advanced Technology
2024
South China Agricultural University
2024
Despite years of intensive research, much remains to be discovered understand the regulatory networks coordinating bacterial cell growth and division. The mechanisms by which Streptococcus pneumoniae achieves its characteristic ellipsoid-cell shape remain largely unknown. In this study, we analyzed interplay division paralogs DivIVA GpsB with ser/thr kinase StkP. We observed that deletion divIVA hindered elongation resulted in shortening rounding. By contrast, absence hampered triggered...
Abstract Background The high cost and insufficient supply of human papillomavirus (HPV) vaccines have slowed the pace controlling cervical cancer. A phase III clinical trial was conducted to evaluate efficacy, safety, immunogenicity a novel Escherichia coli-produced bivalent HPV-16/18 vaccine. Methods multicenter, randomized, double-blind started on November 22, 2012 in China. In total, 7372 eligible women aged 18–45 years were age-stratified randomly assigned receive three doses test or...
The relationship of PAX1/JAM3 methylation as well HPV viral load (VL) with cervical lesions has been reported, but their role in persistent infection without high-grade not fully elucidated. A total 231 females diagnosed and pathologically confirmed absence were selected from the Colposcopy Outpatient Clinic Peking University People’s Hospital, March 2023 to December 2023. They categorized into two groups based on duration infection: less than 3 years group more group. VL determined by...
Cyclophilin A (CypA), predominantly located intracellularly, is a multifunctional protein. We previously reported decreased CypA levels in hepatocytes of transgenic mice expressing hepatitis B virus (HBV) surface antigen (HBsAg). In this study, we found that expression HBV small protein (SHBs) human hepatoma cell lines specifically triggered secretion, whereas SHBs added extracellularly to culture medium did not. Moreover, secretion was not promoted by the deficient mutant, suggesting close...
Naoxintong (NXT) is a Chinese Materia Medica standardized product extracted from 16 various kinds of traditional herbal medicines including Salvia miltiorrhiza, Angelica sinensis, Astragali Radix. clinically effective in treating ischaemia heart disease. Nucleotide-binding oligomerization domain-Like Receptor with Pyrin domain 3 (NLRP3) inflammasome has been critically involved myocardial ischaemia/reperfusion (I/R) injury. Here, we have suggested that NXT might attenuate I/R injury via...
The gut microbiota is a complex and essential system organ that plays an integrative role in balancing key vital functions the host. Knowledge of impact altitude on European mouflon (Ovis orientalis musimon) blue sheep (Pseudois nayaur) currently limited. In this study, we compared characteristics 5 at low (K group), 4 high (L (M (N group). V3-V4 region 16S rRNA gene was analyzed using high-throughput sequencing. Analyses based operational taxonomic units showed significant changes microbial...
Abstract This experiment aimed to investigate the impact of malic acid (MA) and citric (CA) on nutritional composition, fermentation quality, rumen degradation rate, microbial diversity a mixture apple pomace corn protein powder during ensiling. The used as raw materials, with four groups: control group (CON), treatment (MA, 10 g/kg), (CA, + g/kg CA, g/kg). Each has 3 replicates, 2 repetitions in parallel, subjected mixed ensiling for 60 days. results indicated: (1) Compared CON group, crude...
The gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions. Among these, gut-derived serotonin (5-hydroxytryptamine, 5-HT), synthesized from tryptophan metabolism, has been identified as key mediator. However, it remains unclear whether specific microbial factors regulate metabolism to influence 5-HT production regulation. In this study, we analyzed 110 athletes undergoing closed training...