A5028093998- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Advanced Proteomics Techniques and Applications
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS Research and Interventions
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Diabetes Management and Research
- HIV Research and Treatment
- Pelvic and Acetabular Injuries
- HIV/AIDS drug development and treatment
- Ginseng Biological Effects and Applications
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Cancer, Lipids, and Metabolism
Second Xiangya Hospital of Central South University
2021-2025
Central South University
2021-2025
National Clinical Research
2024-2025
First Affiliated Hospital of Jiamusi University
2023-2025
Guangxi University of Chinese Medicine
2023-2024
Harbin Medical University
2024
Peking University
2024
Peking Union Medical College Hospital
2017-2024
Shanghai Jiao Tong University
2008-2024
Kunming Medical University
2024
Expression of type I interferons (IFNs) can be induced by DNA-damaging agents, but the mechanisms and significance this regulation are not completely understood. We found that transcription factor IRF3, activated in an ATM-IKKα/β-dependent manner, stimulates cell-autonomous IFN-β expression response to double-stranded DNA breaks. Cells tissues with accumulating damage produce endogenous stimulate IFN signaling vitro vivo. In turn, acts amplify DNA-damage responses, activate p53 pathway,...
Abstract Background The high cost and insufficient supply of human papillomavirus (HPV) vaccines have slowed the pace controlling cervical cancer. A phase III clinical trial was conducted to evaluate efficacy, safety, immunogenicity a novel Escherichia coli-produced bivalent HPV-16/18 vaccine. Methods multicenter, randomized, double-blind started on November 22, 2012 in China. In total, 7372 eligible women aged 18–45 years were age-stratified randomly assigned receive three doses test or...
Abstract Background Inflammation-related predisposition to cancer plays an essential role in progression and is associated with poor prognosis. A hypoxic microenvironment neutrophil infiltration are commonly present solid tumours, including gastric (GC). Neutrophil extracellular traps (NETs) have also been demonstrated the tumour immune (TIME), but how NETs affect GC remains unknown. Here, we investigated of NET formation TIME further explored underlying mechanism growth. Methods...
Abstract Bacteria-triggered sepsis is characterized by systemic, uncontrolled inflammation in affected individuals. Controlling the excessive production of pro-inflammatory cytokines and subsequent organ dysfunction remains challenging. Here, we demonstrate that Spi2a upregulation lipopolysaccharide (LPS)-stimulated bone marrow-derived macrophages reduces myocardial impairment. In addition, exposure to LPS upregulates lysine acetyltransferase, KAT2B, promote METTL14 protein stability through...
The impact of dietary fat intake on long-term human health has attracted substantial research interest, and the effects diverse fats depend available food sources. Yet there is a paucity data elucidating links between from specific sources health.
A proper cellular adaptation to low oxygen levels is essential for processes such as development, growth, metabolism, and angiogenesis. The response decrease in supply, referred hypoxia, also involved numerous human diseases including cancer, inflammatory conditions, vascular disease. hypoxia-inducible factor 1-α (HIF-1α), a key player the hypoxic response, kept under stringent regulation. At normoxia, are consequence of efficient degradation by ubiquitin-proteasome system, blocked...
The great preclinical promise of the pancreatic endoplasmic reticulum kinase (PERK) inhibitors in neurodegenerative disorders and cancers is marred by injury diabetic syndrome observed PERK knockout mice humans lacking function suffering from Wolcott-Rallison syndrome. mediates many unfolded protein response (UPR)-induced events, including degradation type 1 interferon (IFN) receptor IFNAR1 vitro. Here we report that whole-body or pancreas-specific Perk ablation leads to an increase levels...
Immature T cells undergo a process of positive selection in the thymus when their new cell receptor (TCR) engages and signals response to self-peptides. As matures, slew negative regulatory molecules, including inhibitory surface glycoprotein CD5, are up-regulated proportion strength self-peptide signal. Together these regulators dampen TCR-proximal signaling help avoid any subsequent peripheral activation by Paradoxically, antigen-specific initially expressing more CD5 (CD5hi) have been...
Programmed cell death ligand 1 (PD-L1) expression on immune cells is correlated with the efficacy of checkpoint inhibitor (ICI) therapy in various types cancer. Platelets are important components tumour microenvironment (TME) and widely involved development many cancer including colorectal (CRC). However, role PD-L1 positive platelets ICI for CRC remains unknown. We hypothesized that trigger sustain immunosuppression. The functional depletion effects TME were measured via western blotting,...
To determine whether tea consumption is associated with risk of type 2 diabetes (T2D), to elucidate potential effect modification by genetic susceptibility, and examine metabolic biomarkers as mediators for the association. We conducted a cohort analysis 382,946 participants in UK Biobank. Multivariable-adjusted age-stratified Cox proportional hazards regression models were used calculate hazard ratios (HRs) 95% confidence intervals (CIs) association between T2D risk. During median follow-up...
Abstract Background Abnormal metabolism and perturbations in metabolic pathways play significant roles the development progression of prostate cancer; however, comprehensive metabolomic analyses human data are lacking needed to elucidate interrelationships. Methods We examined serum metabolome relation cancer survival a cohort 1812 cases Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Using an ultrahigh-performance LC-MS/MS platform, we identified 961 known metabolites...
Abstract Cis-regulatory changes are thought to play a major role in adaptation. Threespine sticklebacks have repeatedly colonized freshwater habitats the Northern Hemisphere, where they evolved suite of phenotypes that distinguish them from marine populations, including physiology, behavior, and morphology. To understand gene regulatory evolution adaptive divergence, here we investigate cis-regulatory expression between ecotypes through allele-specific (ASE) F1 hybrids. Surveying seven...