A5100785995- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Immunodeficiency and Autoimmune Disorders
- CRISPR and Genetic Engineering
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Gut microbiota and health
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Liver physiology and pathology
- Gout, Hyperuricemia, Uric Acid
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Parasitic Diseases Research and Treatment
- Cancer Immunotherapy and Biomarkers
Sun Yat-sen University
2009-2025
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Jilin University
2025
Hospital of Hebei Province
2022-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Southern University of Science and Technology
2023-2024
Peking University
2014-2024
Beijing Friendship Hospital
2024
Capital Medical University
2022-2024
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2024
Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the orchestration metabolic pathways in regulating ferroptosis will provide new insights into TNBC therapeutic strategies. Here, we integrated multiomics data our large cohort (n = 465) to develop atlas. We discovered that TNBCs had heterogeneous phenotypes ferroptosis-related metabolites and pathways. The luminal androgen receptor (LAR) subtype was characterized by upregulation oxidized...
Abstract Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the polar metabolome and lipidome 330 TNBC samples 149 paired normal tissues to construct large metabolomic atlas TNBC. Combining with previously established transcriptomic genomic data same cohort, we conducted comprehensive analysis linking genomics. classified TNBCs into three distinct subgroups: C1,...
Colorectal cancer is one of the most frequently diagnosed cancers worldwide. Gut flora can modulate host response to chemotherapeutic drugs. However, understanding regarding relationship between gut microbiota and antitumor efficacy 5- Fluorouracil (5-FU) treatment limited. Therefore, we compared tumor size profiled mice treated with 5-FU, combined probiotics or ABX (an antibiotic cocktail antibiotics) by using Cancer (CRC) mouse model high-throughput sequencing. The results elucidated that...
Abstract Background Inflammation-related predisposition to cancer plays an essential role in progression and is associated with poor prognosis. A hypoxic microenvironment neutrophil infiltration are commonly present solid tumours, including gastric (GC). Neutrophil extracellular traps (NETs) have also been demonstrated the tumour immune (TIME), but how NETs affect GC remains unknown. Here, we investigated of NET formation TIME further explored underlying mechanism growth. Methods...
Abstract Background Triclosan [5-chloro-2-(2,4-dichlorophenoxy) phenol, TCS], a common antimicrobial additive in many personal care and health products, is frequently detected human blood urine. Therefore, it has been considered an emerging potentially toxic pollutant recent years. Long-term exposure to TCS suggested exert endocrine disruption effects, promote liver fibrogenesis tumorigenesis. This study was aimed at clarifying the underlying cellular molecular mechanisms of hepatotoxicity...
Sorghum (Sorghum bicolor (L.) Moench) is a world cereal crop used in China for producing Baijiu, distilled spirit. We report telomere-to-telomere genome assembly of the Baijiu cultivar Hongyingzi, HYZ-T2T, using ultralong reads. The 10 chromosome pairs contained 33,462 genes, which 93% were functionally annotated. 20 telomeres and centromeric regions on HYZ-T2T chromosomes predicted two consecutive large inversions 2 characterized. A 65-gene reconstruction metabolic pathway tannins, flavor...
Aims: Chlorogenic acid (CGA) is a phenolic that has wide range of pharmacological effects. However, the protective effects and mechanisms CGA on liver fibrosis are not clear. This study explored miR-21-regulated TGF-β1/Smad7 in hepatic stellate LX2 cell line CCl4-induced Sprague-Dawley rats. Methods: The mRNA expression miR-21, Smad7, connective tissue growth factor (CTGF), α-smooth muscle actin (α-SMA), inhibitor metalloproteinase 1 (TIMP-1), matrix metalloproteinase-9 (MMP-9), transforming...
The aim of this study was to the molecular characteristics Trichinella spiralis galectin (Tsgal) and interactions between Tsgal host's intestinal epithelial cells (IECs). functional domain cloned expressed in an E. coli system. 97.1% identity T. nativa 20.8% galectin-8 humans. Conserved analysis revealed that belongs TR-type has two carbon recognized domain. rTsgal with 29.1 kDa could be by spiralis-infected mice at 42 days post-infection (dpi). transcription expression gene detected RT-PCR...
In our previous work, a Trichinella spiralis putative serine protease (TsSP) was identified from ES products of T. intestinal infective larvae (IIL) and adult worms (AW) by immunoproteomics: it highly expressed in IIL compared with muscle (ML). this study, the TsSP biological characteristics larval invasion growth were its potential as vaccine target against infection investigated. Expression at various developmental phases (newborn larvae, ML, IIL, AW) detected qPCR, immunofluorescent test...
Trichinella spiralis serine protease inhibitor (TsSPI) was identified in ES proteins of adult worms (AW), the TsSPI gene highly expressed at enteral stage (AW and newborn larvae), distributed mainly cuticle stichosome this nematode. Vaccination mice with rTsSPI exhibited a 62.2% reduction intestinal AW 57.25% muscle larvae after larval challenge. The aim study to investigate biological characteristics its roles process T. invasion host's epithelium cells (IECs). inhibition on trypsin...
Abstract Triple‐negative breast cancer (TNBC) exhibits resistance to conventional treatments due the presence of stem cells (CSCs), causing postsurgical relapse and a dismal prognosis. Umbilical cord blood natural killer (UCB‐NK) cell‐based immunotherapy represents promising strategy for treatment. However, its therapeutic efficacy is greatly restrained by downregulation NK cell activation ligand MHC class I‐related chain A/B (MICA/B) autophagy‐mediated degradation cell‐derived granzyme B...
It has been widely accepted that monocytes are one of the central mediators contributing to inflammaging. However, it remains unclear whether aged monocytes, similar T cells, have characteristics hyperactivation and increased expression co-inhibitory molecules.Peripheral blood mononuclear cells (PBMCs) were isolated from young (21-40 years old), middle-aged (41-60 older human subjects (> 60 old). Flow cytometry was used monitor changes in surface molecules monocyte subsets cytokine-producing...
Deoxyribonuclease II (DNase II) is a widespread endonuclease which can degrade the DNA. Trichinella spiralis adult-specific DNase II-1 (TsDNase II-1)/DNase II-7 II-7) were identified in excretory–secretory (ES) or surface proteins of adult worm (AW) and intestinal infective larvae (IIL) using immunoproteomics with early infection sera. The aim this study was to characterize two T. investigate their potential for vaccine candidate target molecules. cDNA sequences from 3 d AW cloned expressed....
Cardiac remodeling caused by acute myocardial infarction (AMI) represents a major challenge for heart failure research. MiR-155 has been identified as key mediator of cardiac inflammation and hypertrophy. In this study, we investigate the role miR-155 in induced AMI. We demonstrate that expressed fibroblasts is potent contributor to remodeling. reveal vivo, knockout improves left ventricular function, reduces infarct size, attenuates collagen deposition, whereas overexpression produces...
SUMMARY Prolonged viral shedding is associated with severe status and poor prognosis of COVID-19 patients. Unexpectedly, here we report a non-severe patient the longest duration shedding. According to investigation on clinical epidemiological information this case, concluded that type virus might have low toxicity transmissibility, but prolonged infective ability was hardly be eliminated in body regular therapy. However, infusion plasma from recovered patients showed high efficiency...
Dear Editor, Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a threat to global health.1-3 The clinical spectrum in COVID-19 patients presents diversety.4, 5 Viral shedding is critical indicator for prognosis, and prolonged viral always predicts poor outcome.5, 6 In this report, however, we describe special case of family cluster with mild type COVID-19. one member, the duration from illness onset persisted over 49 days...