A5100605415- Autophagy in Disease and Therapy
- ECG Monitoring and Analysis
- EEG and Brain-Computer Interfaces
- MicroRNA in disease regulation
- Heart Rate Variability and Autonomic Control
- Inflammasome and immune disorders
- CRISPR and Genetic Engineering
- Adipokines, Inflammation, and Metabolic Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Non-Invasive Vital Sign Monitoring
- Neurological Disease Mechanisms and Treatments
- Virus-based gene therapy research
- Cancer Research and Treatments
- Biological and pharmacological studies of plants
- Case Reports on Hematomas
- Cancer-related molecular mechanisms research
- Ion Transport and Channel Regulation
- Neurogenesis and neuroplasticity mechanisms
- Hippo pathway signaling and YAP/TAZ
- Receptor Mechanisms and Signaling
- Organ Transplantation Techniques and Outcomes
- Blind Source Separation Techniques
- Mesenchymal stem cell research
- Parathyroid Disorders and Treatments
- Advanced Glycation End Products research
Fudan University
2011-2025
Huadong Hospital
2015-2025
Institute of Biophysics
2022
Chinese Academy of Sciences
2022
Nanjing Medical University
2021
YangPu Geriatric Hospital
2019
Jinzhou Medical University
2015-2016
First Affiliated Hospital of Liaoning Medical University
2015
Wuhan University
2014
Ludong University
2012
Abstract Ischemic preconditioning (IPC) has a strong renoprotective effect during renal ischemia/reperfusion (I/R) injury that is thought to relate autophagy. However, the role of autophagy IPC-afforded renoprotection and precise mechanisms involved are unknown. In this study, an in vitro hypoxia/reoxygenation (H/R) model was established which oxygen glucose deprivation (OGD) applied cells for 15 h followed by reoxygenation under normal conditions 30 min, 2 or 6 h; transient OGD subsequent...
Hyperuricemia contributes to renal inflammation. We aimed investigate the role of Na+–K+–ATPase (NKA) in hyperuricemia-induced tubular injury. Human primary proximal epithelial cells (PTECs) were incubated with uric acid (UA) at increasing doses or for lengths time. PTECs then stimulated by pre-incubation an NKA α1 expression vector small interfering RNA before UA (100 μg ml−1, 48 h) stimulation. Hyperuricemic rats induced gastric oxonic and treated febuxostat (Feb). ATP levels, activity its...
The objective of this study is to investigate the dynamic changes in serum albumin and ferritin as potential predictors for early-onset peritoneal dialysis-related peritonitis (PDRP) patients undergoing dialysis (PD).
Autophagy is important for cellular survival during renal ischemia/reperfusion (I/R) injury. Ischemic preconditioning (IPC) has a strong renoprotective effect I/R. Our study here aimed to explore the of IPC on autophagy I/R Rats were subjected unilateral ischemia with or without prior IPC. Hypoxia/reoxygenation (H/R) injury was induced in HK-2 cells hypoxic (HPC). and apoptosis detected after reperfusion reoxygenation different time. The results showed that levels LC3II, Beclin-1,...
While a number of therapeutic advances have been made in recent years, the overall survival patients with head and neck squamous cell cancer (HNSCC) remains poor. MicroRNAs (miRNAs) are key drivers oncogenic progression, miR-34a-5p downregulation having observed many different tumor types. Here, we assessed link between HNSCC progression mechanistic basis for this relationship. Levels tumors lines were via qPCR, after which explored functional importance miRNA setting. Through luciferase...
Recent research indicates a significant relationship between the severity of depression and heart rate variability (HRV). This paper presents neuro-fuzzy approach-based classification algorithm, which distinguishes patients with from controls by network weighted fuzzy membership function (NEWFM) using two time domain four frequency features HRV. The HRV data were collected 10 an equal number healthy controls. Wearing wireless Holter monitor, each subject underwent 13-minute multimodal...
Mitochondrial dysfunction has been implicated in the early stages or progression of many renal diseases. Improving mitochondrial function and homeostasis potential to protect function. Serum- glucocorticoid-induced kinase 1 (SGK1) is known regulate various cellular processes, including cell survival. In this study, we intend demonstrate effect molecular mechanisms SGK1 tubular cells upon oxidative stress injury determine whether regulation process. HK-2 were exposed H 2 O , viability...
Adiponectin (APN) exerts anti‑inflammatory effects in various cells. Uric acid (UA) induces inflammation proximal renal tubular epithelial cells (PTECs). It remains unknown whether APN protects against UA‑induced inflammation. In the present study, human PTECs were incubated with 100 µg/ml soluble (S) UA presence or absence of globular (g) APN, receptor 1 (AdipoR1)‑short hairpin RNA lentivirus compound C. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) assays performed...
The increasing complexity and high costs associated with modern processor design have led to a surge in demand for automation. Instruction-tuned large language models (LLMs) demonstrated remarkable performance automatically generating code general-purpose programming languages like Python. However, these methods fail on hardware description (HDLs) Verilog due the scarcity of high-quality instruction tuning data, as even advanced LLMs GPT-3.5 exhibit limited generation. Regarding this issue,...
Proton pump inhibitors as adjunctive therapy would improve diabetes control and could enhance the hypoglycaemic activity of DPP-4 inhibitors. The aim study was to investigate short-term effects lansoprazole (LPZ), sitagliptin (SITA) their combination on glucose regulation gut peptide secretion.Glucose were determined compared after administration LPZ or SITA, in mice with diet-induced obesity (DIO) healthy human subjects (n = 16) a 75 g oral tolerance test (OGTT) by crossover design.In DIO...
This paper presents a real-time algorithm for mobile cardiac monitoring system to detect life-threatening arrhythmias. detection focuses on two arrhythmias ventricular tachycardia and fibrillation (VT/VF), which are detected through the application of pre-detection processing main processing. In processing, applies statistical method VT/VF. contrast, neural fuzzy network is applied VT/VF in The network's input features obtained by wavelet transform several effective extraction methods....
The ventricular arrhythmias including tachycardia (VT) and fibrillation (VF) are life-threatening heart diseases. This paper presents an approach to detect normal sinus rhythm (NSR) VF/VT using the neural network with weighted fuzzy membership functions (NEWFM). NEWFM classifies NSR beats by trained bounded sum of (BSWFMs) one input features from Creighton University Ventricular Tachyarrhythmia Data Base (CUDB). In this paper, six obtained two steps. first step, 8s original ECG signal...
본 논문은 가중 퍼지소속함수 기반 신경망 (Neural Network with Weighted Fuzzy Membership functions, NEWFM)과 심박수 변이도(Heart Rate Variability, HRV)를 이용하여 우울증 진단알고리즘을 제안하고 있다. 알고리즘에서 사용할 NEWFM의 입력특징을 추출하기 위해서 주파수도메인 특징추출, 시간도메인 웨이블릿변환 포인케어변환 특징추출 방법을 22개의 초기 HRV 특징들을 추출하였다. 또한 NEWFM에서 제공하는 비중복면적 분산측정법 (Non-overlap Area Distribution Measurement, NADM)에 의해 입력특징의 중요도를 평가하여 초기특징으로부터 중요도가 가장 높은 6개 최적입력특징을 선택하였다. 이 특징을 우울증을 진단한 결과는 95.8% 의 정확도를 나타내었다. This paper presents an algorithm for depression diagnosis using the...