A5100704293- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Advanced Glycation End Products research
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Poisoning and overdose treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Calpain Protease Function and Regulation
- Adenosine and Purinergic Signaling
- Diabetes and associated disorders
- GDF15 and Related Biomarkers
- Gout, Hyperuricemia, Uric Acid
- Case Reports on Hematomas
- Circular RNAs in diseases
- Chronic Disease Management Strategies
- Antioxidant Activity and Oxidative Stress
- Organ Transplantation Techniques and Outcomes
- Body Composition Measurement Techniques
- Heavy Metal Exposure and Toxicity
Second Affiliated Hospital of Soochow University
2011-2024
Soochow University
2011-2024
Shanghai Jiao Tong University
2021
Huadong Hospital
2018
Fudan University
2018
YangPu Geriatric Hospital
2018
Central South University
2014
Advanced glycation end-products (AGEs) contribute to the pathogenesis of diabetes mellitus and atherosclerosis by promoting vascular endothelial cell proliferation, migration, damage death. In this study, we examined role autophagy in HUVECs exposed AGE-modified bovine serum albumin (AGE-BSA). incubated with AGE-BSA for 6 h showed an increase formation acidic vesicular organelles autophagosomes. AGE-BSA-induced upregulation microtubule associated protein 1 light chain 3-II (LC3-II), a marker...
Oxidized low‐density lipoprotein‐ (Ox‐LDL‐) induced autophagy dysfunction in human vascular endothelial cells contributes to the development of atherosclerosis (AS). Resveratrol (RSV) protects against Ox‐LDL‐induced endothelium injury. The objective this study was determine mechanisms underlying and RSV‐mediated protection umbilical vein (HUVECs). results showed that Ox‐LDL suppressed expression sirtuin 1 (SIRT1) increased LC3‐II sequestosome (p62) protein levels without altering p62 mRNA...
Abstract Ischemic preconditioning (IPC) has a strong renoprotective effect during renal ischemia/reperfusion (I/R) injury that is thought to relate autophagy. However, the role of autophagy IPC-afforded renoprotection and precise mechanisms involved are unknown. In this study, an in vitro hypoxia/reoxygenation (H/R) model was established which oxygen glucose deprivation (OGD) applied cells for 15 h followed by reoxygenation under normal conditions 30 min, 2 or 6 h; transient OGD subsequent...
To investigate the association of sarcopenia index (SI) [(serum creatinine/serum cystatin C) × 100] with mortality, nutritional risk/malnutrition and among hospitalized older adults.A prospective analysis was performed in 758 adults. Anthropometric measures biochemical parameters were carried out for each patient. Sarcopenia defined according to Asian Working Group (AWGS) 2019 algorithm. Nutritional European Society Clinical Nutrition Metabolism (ESPEN) criteria. The logistic regression...
Background: Hexavalent chromium (Cr(VI)) overdose causes hepatocellular injuries by inducing mitochondrial damage and subsequent apoptosis in animals humans. Autophagy can selectively remove damaged organelles, especially impaired mitochondria, turn, protects against mitochondria-dependent cell death. The present study was designed to explore the effects of autophagy on Cr(VI)-induced hepatotoxicity. Methods: L-02 hepatocytes were incubated with different concentrations Cr(VI) for 24h...
Hyperuricemia contributes to renal inflammation. We aimed investigate the role of Na+–K+–ATPase (NKA) in hyperuricemia-induced tubular injury. Human primary proximal epithelial cells (PTECs) were incubated with uric acid (UA) at increasing doses or for lengths time. PTECs then stimulated by pre-incubation an NKA α1 expression vector small interfering RNA before UA (100 μg ml−1, 48 h) stimulation. Hyperuricemic rats induced gastric oxonic and treated febuxostat (Feb). ATP levels, activity its...
Autophagy is important for cellular survival during renal ischemia/reperfusion (I/R) injury. Ischemic preconditioning (IPC) has a strong renoprotective effect I/R. Our study here aimed to explore the of IPC on autophagy I/R Rats were subjected unilateral ischemia with or without prior IPC. Hypoxia/reoxygenation (H/R) injury was induced in HK-2 cells hypoxic (HPC). and apoptosis detected after reperfusion reoxygenation different time. The results showed that levels LC3II, Beclin-1,...
<b><i>Objectives:</i></b> Oxidized low-density lipoprotein (ox-LDL) may induce autophagy, apoptosis, necrosis or proliferation of cultured endothelial cells depending on the concentration and exposure time. Our previous studies found that ox-LDL for 6 h increases autophagic level human umbilical vein (HUVECs) in a concentration-dependent manner. The present study investigates relationship between autophagy apoptosis HUVECs exposed to ox-LDL....
Humanin, a newly emerging endogenously expressed cytoprotective peptide, has been shown to have anti-apoptotic properties effects by protecting neuronal cells injury. Endothelial microparticles (EMPs) are considered as vital mediators in intercellular communication. EMPs may regulate various physiological and pathological processes transferring mRNAs microRNAs (miRNAs) recipient cells.EMPs were isolated from human umbilical vein endothelial (HUVECs) ultracentrifugation. characterized...
High glucose (HG) induced endothelial senescence is related to dysfunction and cardiovascular complications in diabetic patients. Humanin, a member of mitochondrial derived peptides (MDPs), thought contribute aging-related protection. The goal the study explore pathogenesis HG-induced potential anti-senescent effects Humanin. Human umbilical vein cells (HUVECs) were exposed induce senescence, determined by β-galactosidase staining expressions p21, p53, p16. A clinically relevant dose HG (15...