A5076575104- Animal Virus Infections Studies
- Virus-based gene therapy research
- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Calpain Protease Function and Regulation
- Blood Pressure and Hypertension Studies
- Circular RNAs in diseases
- Animal Disease Management and Epidemiology
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Immune Cell Function and Interaction
Sun Yat-sen University
2022-2024
Sun Yat-sen University Cancer Center
2022-2024
State Key Laboratory of Oncology in South China
2023
Guangzhou Medical University
2023
Stomatology Hospital
2023
Qingdao University
2023
Suzhou Traditional Chinese Medicine Hospital
2016-2022
China Medical University
2022
Nanjing University of Chinese Medicine
2021-2022
South China Agricultural University
2018-2021
Microbiota-tumor interactions have qualified microbiota as a promising prognostic biomarker in various types of cancers. Although the nasopharynx acts crucial niche upper respiratory tract microbiome, whether intratumoral exists and its clinical significance nasopharyngeal carcinoma (NPC) remain uncertain.To evaluate for individual prognostication patients with NPC.This retrospective cohort study included NPC biopsy samples from 2 hospitals: Sun Yat-sen University Cancer Center (Guangzhou,...
Abstract Although radiotherapy can promote antitumour immunity, the mechanisms underlying this phenomenon remain unclear. Here, we demonstrate that expression of E3 ubiquitin ligase, tumour cell-intrinsic tripartite motif-containing 21 (TRIM21) in tumours, is inversely associated with response to radiation and CD8 + T cell-mediated immunity nasopharyngeal carcinoma (NPC). Knockout TRIM21 modulates cGAS/STING cytosolic DNA sensing pathway, potentiates antigen-presenting capacity NPC cells,...
Abstract Increasing evidence has revealed the roles of long noncoding RNAs (lncRNAs) as tumor biomarkers. Here, we introduce an immune-associated nine-lncRNA signature for predicting distant metastasis in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). The nine lncRNAs are identified through microarray profiling, followed by RT–qPCR validation and selection using a machine learning method training cohort ( n = 177). This classifies patients into high low risk groups, which have...
Advanced glycation end-products (AGEs) contribute to the pathogenesis of diabetes mellitus and atherosclerosis by promoting vascular endothelial cell proliferation, migration, damage death. In this study, we examined role autophagy in HUVECs exposed AGE-modified bovine serum albumin (AGE-BSA). incubated with AGE-BSA for 6 h showed an increase formation acidic vesicular organelles autophagosomes. AGE-BSA-induced upregulation microtubule associated protein 1 light chain 3-II (LC3-II), a marker...
Abstract Purpose: Cisplatin-based chemotherapy effectively improves the distant-metastasis control in nasopharyngeal carcinoma (NPC), but approximately 30% of patients develop treatment failure due to chemoresistance. However, underlying mechanisms remain poorly understood. Experimental Design: Circular RNA (circRNA) sequencing data were used identify metastasis-specific circRNAs and expression circIPO7 was validated NPC tissues as well cell lines by qRT-PCR. The whole transcriptional...
Senescence is associated with tumor metastasis and chemotherapy resistance, yet the mechanisms remain elusive. Here, it identified that nasopharyngeal carcinoma (NPC) patients who developed distant are characterized by senescence phenotypes, in which circWDR37 a key regulator. CircWDR37 deficiency limits cisplatin or gemcitabine-induced senescent NPC cells from proliferation, migration, invasion. Mechanistically, binds to dimerizes double-stranded RNA-activated protein kinase R (PKR)...
Abstract The profound influence of microbiota in cancer initiation and progression has been under the spotlight for years, leading to numerous researches on microbiome entering clinical evaluation. As promising biomarkers therapeutic targets, critical involvement practice increasingly appreciated. Here, recent progress this field is reviewed. We describe potential tumor-associated as effective diagnostic prognostic biomarkers, respectively. In addition, we highlight relationship between...
Background: The low-density lipoprotein cholesterol/high-density cholesterol (LDL-C/HDL-C) ratio has been recognized as a strong risk predictor of cardiovascular diseases. However, the association between LDL-C/HDL-C and prognosis acute intracranial hemorrhage (ICH) is unclear. Thus, we prospectively investigated whether low could predict all-cause mortality superior to traditional lipid profiles in predicting among Chinese patients with ICH.Methods: A prospective cohort study 356 ICH was...
Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal carcinoma, but the exact regulatory mechanism underlying chemoresistance carcinoma remains to be elucidated. Here, we identify PJA1 as key E3 ubiquitin ligase involved that highly expressed nonresponse docetaxel-cisplatin-5-fluorouracil induction chemotherapy. We find facilitates docetaxel resistance by inhibiting GSDME-mediated pyroptosis cells. Mechanistically, promotes degradation of mitochondrial...
Background: Aloin, as a bioactive compound, has variety of pharmacological functions, but its effects on combined allergic rhinitis and asthma syndrome (CARAS) have not been studied. To clarify the protective effect mechanism aloin in treatment CARAS by network pharmacology, molecular dynamics simulation experiment. Methods: The targets aloin, were obtained from various databases. protein interaction was constructed for common targets, docking simulations performed core targets. Functional...
The tumor microbiome is believed to have a profound impact on progression owing its local colonization in the microenvironment (TME). Using Cancer Microbiome Atlas (TCMA), database of curated, decontaminated microbial profiles for 3,689 oropharyngeal, esophageal, gastrointestinal, and colorectal tissue samples from 1,772 patients, we conducted comprehensive multi-omics analysis reveal signatures among various cancers potential mechanisms involved head neck squamous cell carcinoma (HNSC). We...
Abstract Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays crucial role development various tumors. Nevertheless, biological and mechanism ARNTL2 are not fully elucidated NPC. In this study, expression was significantly upregulated NPC tissues cells. Overexpression facilitated cell migration invasion abilities, while inhibition similarly treated cells blunted...
Abstract The identification of predictors for immunotherapy is often hampered by the absence control groups in many studies, making it difficult to distinguish between prognostic and predictive biomarkers. This study presents biomarker analyses from phase 3 CONTINUUM trial (NCT03700476), first show that adding anti-PD-1 (aPD1) chemoradiotherapy (CRT) improves event-free survival (EFS) patients with locoregionally advanced nasopharyngeal carcinoma. A dynamic single-cell atlas was profiled...
<b><i>Objectives:</i></b> Oxidized low-density lipoprotein (ox-LDL) may induce autophagy, apoptosis, necrosis or proliferation of cultured endothelial cells depending on the concentration and exposure time. Our previous studies found that ox-LDL for 6 h increases autophagic level human umbilical vein (HUVECs) in a concentration-dependent manner. The present study investigates relationship between autophagy apoptosis HUVECs exposed to ox-LDL....
Puerarin is the main isoflavone extracted from Radix Puerariae lobata (Willd.) and exerts a strong protective effect on endothelial cells. This also proven angiogenic effects; however, potential underlying mechanism has not been fully explored. Here in this work, we aimed to determine proangiogenesis of puerarin-attached lignin nanoparticle-incorporated hydrogel explore mechanism.Puerarin-attached nanoparticles were fabricated mixed with GelMA hydrogel. After was characterized, evaluated...
ABSTRACT The development of effective vaccines against porcine circovirus type 2 (PCV2) has been accepted as an important strategy in the prophylaxis post‐weaning multisystemic wasting syndrome; a DNA vaccine expressing major immunogenic capsid (Cap) protein PCV2 is considered to be promising candidate. However, usually induce weak immune responses. In this study, it was found that efficacy Cap improved by simultaneous expression IL‐6. A plasmid (pIRES‐ORF2/IL6) separately both and IL‐6...
Double-stranded RNA (dsRNA)-dependent protein kinase R (PKR) activation via autophosphorylation is the central cellular response to stress that promotes cell death or apoptosis. However, key factors and mechanisms behind simultaneous of pro-survival signaling pathways remain unknown. We have discovered a novel regulatory mechanism for maintenance homeostasis relies on phosphorylation interplay between sphingosine 1 (SPHK1) PKR during exogenous stress. identified SPHK1 as previously...