A5032868375- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Brain Metastases and Treatment
- Oral health in cancer treatment
- Cancer-related gene regulation
- Cardiac electrophysiology and arrhythmias
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Congenital Heart Disease Studies
- Congenital heart defects research
- Plasma Applications and Diagnostics
- Cardiac Arrhythmias and Treatments
- Asymmetric Hydrogenation and Catalysis
- Colorectal and Anal Carcinomas
- Tracheal and airway disorders
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
Zhejiang Cancer Hospital
2016-2025
Army Medical University
2025
University of Chinese Academy of Sciences
2007-2025
Guiyang Medical University
2023-2025
Ocean University of China
2025
Chinese Academy of Sciences
2019-2024
Zunyi Medical University
2024
Zhongkai University of Agriculture and Engineering
2024
Xiamen Tobacco Industry (China)
2024
The First People's Hospital of Guiyang
2023
Abstract Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor originating in the nasopharynx and has high incidence Southeast Asia North Africa. To develop these comprehensive guidelines for diagnosis management of NPC, Chinese Society Clinical Oncology (CSCO) arranged multi‐disciplinary team comprising experts from all sub‐specialties NPC to write, discuss, revise guidelines. Based on findings evidence‐based medicine China abroad, domestic have iteratively developed provide proper...
To report long‐term results of a randomized controlled trial that compared cisplatin/fluorouracil/docetaxel (TPF) induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) with CCRT alone in locoregionally advanced nasopharyngeal carcinoma (NPC). Patients stage III–IVB (except T3–4 N0) NPC were randomly assigned to receive IC (n = 241) or 239). included three cycles docetaxel (60 mg/m 2 d1), cisplatin and fluorouracil (600 /d civ d1–5) every 3 weeks. from both groups received...
Checkpoint inhibitors are effective in recurrent/metastatic nasopharyngeal cancer (R/M NPC). RATIONALE-309 (NCT03924986) randomized 263 treatment-naive R/M NPC patients to tislelizumab or placebo every 3 weeks (Q3W), plus chemotherapy (Q3W for 4-6 cycles). At interim analysis, progression-free survival (PFS) was significantly longer with tislelizumab-chemotherapy versus placebo-chemotherapy (hazard ratio: 0.52; 95% confidence interval: 0.38, 0.73; p < 0.0001). PFS benefit observed regardless...
Microbiota-tumor interactions have qualified microbiota as a promising prognostic biomarker in various types of cancers. Although the nasopharynx acts crucial niche upper respiratory tract microbiome, whether intratumoral exists and its clinical significance nasopharyngeal carcinoma (NPC) remain uncertain.To evaluate for individual prognostication patients with NPC.This retrospective cohort study included NPC biopsy samples from 2 hospitals: Sun Yat-sen University Cancer Center (Guangzhou,...
Importance There are currently no therapies approved by the US Food and Drug Administration for nasopharyngeal carcinoma (NPC). Gemcitabine-cisplatin is current standard of care first-line treatment recurrent or metastatic NPC (RM-NPC). Objective To determine whether toripalimab in combination with gemcitabine-cisplatin will significantly improve progression-free survival overall as RM-NPC, compared alone. Design, Setting, Participants JUPITER-02 an international, multicenter, randomized,...
Nasopharyngeal carcinoma (NPC) is characterized by a high rate of local invasion and early distant metastasis. Increasing evidence indicates that epigenetic abnormalities play important roles in NPC development. However, the mechanisms underlying metastasis remain unclear. Here we investigate aberrantly methylated transcription factors tissues, identify HOP homeobox HOPX as most significantly hypermethylated gene. Consistently, find HOXP expression downregulated tissues cell lines. Restoring...
GEM20110714 (ClinicalTrials.gov identifier: NCT01528618), the first randomized, phase III study of systemic chemotherapy in recurrent or metastatic nasopharyngeal carcinoma (NPC), reported significant progression-free survival improvement with gemcitabine plus cisplatin (GP) versus fluorouracil (FP; hazard ratio, 0.55; 95% CI, 0.44 to 0.68;
Background This study aimed to evaluate the antitumor activity of camrelizumab, an antiprogrammed cell death-1 antibody, in pretreated recurrent or metastatic nasopharyngeal carcinoma (NPC) and explore predictive biomarkers. Methods Patients with (not amenable locally curative treatment) NPC who had failed at least two lines chemotherapy were eligible receive camrelizumab (200 mg intravenously every 2 weeks) for years until disease progression, intolerable adverse events, withdrawal...
Using nonthermal plasma (NTP) to promote CO2 hydrogenation is one of the most promising approaches that overcome limitations conventional thermal catalysis. However, catalytic surface reaction dynamics NTP-activated species are still under debate. The was investigated in Pd2Ga/SiO2 alloy catalysts and compared conditions. Although both NTP conditions showed close 100% CO selectivity, it worth emphasizing when activated by NTP, conversion not only improves more than 2-fold but also breaks...
Importance Accurate staging is a fundamental step in treating patients with nasopharyngeal carcinoma (NPC) worldwide; this crucial not only for prognostication, but also guiding treatment decisions. The American Joint Committee on Cancer (AJCC)/Union International Control (UICC) tumor-node-metastasis (TNM) system the global language clinicians, researchers, and cancer registries. Continual improvement that aligns contemporary pattern of care essential. Objective To improve prognostic...
LBA6000 Background: Patients with high-risk locoregionally advanced nasopharyngeal carcinoma (NPC) often experience disease relapse even after receiving standard-of-care treatment, e.g. induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT). The benefit of PD-1 inhibitor as adjuvant treatment following IC+CCRT in NPC remains unclear. Methods: (T4N1M0 or T1-4N2-3M0) who have received gemcitabine and cisplatin (GP) IC CCRT were recruited at 11 centers China. They randomly...
Using porous materials for sound absorption is an effective approach to alleviating noise pollution, although their hydrophilic properties potentially cause concerns regarding public safety and health risks. This work provides a facile strategy establishing multifunctional ceramic system by using sponges as the sintering template, adjusting pore structure of foams varying slurry weights fluorinating sintered via hydrolysis condensation processes provide low surface energy. The obtained...
Flaviviruses represent a serious global health threat, infecting millions annually with high rates of cross-infection among different flaviviruses, yet no broad-spectrum antiviral therapy currently targets these pathogens. Through biological big data analysis, we observed significant downregulation Canopy FGF Signaling Regulator 3 (CNPY3), positive regulator defense responses, in flavivirus-infected patients, the level correlating infection severity. This observation was validated cellular...
Inspired by natural enzymes, artificial enzymes have garnered significant interest due to their simplicity of production, robustness under harsh conditions, and enhanced stability. This study introduces, for the first time, a novel Z/Ce@hemin composite enzyme, constructed anchoring hemin onto zeolitic imidazolate framework-8 (ZIF-8)-encapsulated ceria (CeO2) nanoparticles. innovative design overcomes challenges dimerization, enhances substrate affinity, accelerates mass transport, leading...
Importance Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role NPC is unclear. Objective To evaluate the efficacy and safety adjuvant for NPC. Design, Setting, Participants Randomized, open-label, multicenter, phase 3 clinical trial conducted...
Ferroptosis in neurons is considered one of the key factors that induces Parkinson's disease (PD), which caused by excessive iron accumulation intracellular labile pool (LIP). The ions released from LIP lead to aberrant generation reactive oxygen species (ROS) trigger ferroptosis and exacerbate PD progression. Herein, a pioneering design multifunctional nanoregulator deferoxamine (DFO)-integrated nanosheets (BDPR NSs) presented target restrict protect against PD. BDPR NSs are constructed...