A5062837781- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Extraction and Separation Processes
- Nanoparticle-Based Drug Delivery
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Long-Term Effects of COVID-19
- Brain Metastases and Treatment
- Cancer-related gene regulation
- Obesity, Physical Activity, Diet
- Gut microbiota and health
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Effects of Radiation Exposure
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Kunming University
2023-2024
Central Hospital of Wuhan
2024
Henan University
2023
Wuhan Children's Hospital
2023
Sun Yat-sen University Cancer Center
2019
Anhui University
2019
Sun Yat-sen University
2019
University of Colorado Denver
2019
AimsTo investigate separately for men and women whether moderate or high leisure time physical activity, occupational commuting activity are associated with a reduced cardiovascular disease (CVD) all-cause mortality, independent of CVD risk factors other forms activity.
To determine joint associations of different kinds physical activity and the Framingham risk score (FRS) with 10-year coronary heart disease (CHD) events.Study cohorts included 41 053 Finnish participants aged 25-64 years without history CHD stroke. The multivariable-adjusted hazard ratios (HRs) events associated low, moderate, high occupational were 1.00, 0.66, 0.74 (Ptrend<0.001) for men, 0.53, 0.58 women, respectively. HRs leisure-time 0.97, 0.66 (Ptrend=0.002) 0.74, 0.54 (Ptrend=0.003)...
Although radiotherapy (RT) has achieved great success in the treatment of non-small cell lung cancer (NSCLC), local relapses still occur and abscopal effects are rarely seen even when it is combined with immune checkpoint blockers (ICBs). Here, we characterize dynamic changes tumor-infiltrating cells after RT a therapy-resistant murine tumor model using single-cell transcriptomes T receptor sequencing. At early stage, innate adaptive systems activated. late however, microenvironment (TIME)...
Non-small cell lung cancer (NSCLC) metastasizes fairly often to the brain, but identifying which patients will develop brain metastases is problematic. The phosphoinositide 3-kinase (PI3K)-AKT-mTOR signaling pathway important in control of growth, tumorigenesis, and invasion. We hypothesized that genotype variants this could predict metastasis with NSCLC.We genotyped 16 single-nucleotide polymorphisms (SNP) five core genes (PIK3CA, PTEN, AKT1, AKT2, FRAP1) by using DNA from blood samples 317...
Background: Multiple studies have assessed the prognostic significance of serum lactate dehydrogenase (LDH) in patients with breast cancer, but their results remain controversial. This study aimed to evaluate value LDH cancer by meta-analysis. Methods: Electronic searches for relevant articles were conducted PubMed, Embase and Web Science databases. The HR 95% CI used assess LDH. Stata Statistical Software 12.0 was applied statistical analysis. Results: A total 11 involving 6,102 subjected...
Anti-COVID-19 vaccination may have functional implications for immune checkpoint inhibitor treatment in patients with cancer. This study was undertaken to determine whether the safety or efficacy of anti-PD-1 therapy is reduced cancer during COVID-19 vaccination. A large multicenter observational conducted 83 Chinese hospitals between January 28, 2021 and September 30, 2021. total 3552 were screened 2048 eligible receiving PD-1 recruited. All enrolled had received camrelizumab alone...
The association between different types of physical activity and cardiovascular risk among hypertensive subjects is not fully understood. purpose this study was to determine the occupational, commuting, leisure-time on mortality patients. Study cohorts included 26,643 Finnish men women who were aged 25 64 years free coronary heart disease, stroke, Type 1 diabetes. During a mean follow-up 19.9 (range, 6.6 31.7 years), 3743 died because disease. multivariate-adjusted (age, year, education,...
Purpose.: Retinal dopamine has been long implicated in the signaling pathway regulating eye growth, as evidenced by its reduced levels myopic eyes various species. We examined whether and how retinal were changed a C57BL/6 mouse model of experimental myopia. Methods.: Form-deprivation myopia (FDM) was induced mice wearing monocular occluder for 4 weeks. Refractive errors measured using an infrared photorefractor. dopamine/DOPAC vitreal DOPAC assessed high-performance liquid chromatography...
Radiation-induced brain injury (RBI) represents a major challenge for cancer patients undergoing cranial radiotherapy. However, the molecular mechanisms and therapeutic strategies of RBI remain inconclusive. With continuous exploration RBI, an increasing number studies have implicated cerebrovascular dysfunction as key factor in RBI-related cognitive impairment. As pericytes are component neurovascular unit, there is still lack understanding current research about specific role function RBI.
Importance Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role NPC is unclear. Objective To evaluate the efficacy and safety adjuvant for NPC. Design, Setting, Participants Randomized, open-label, multicenter, phase 3 clinical trial conducted...
Pancreatic cancer is among the most aggressive human cancers, and resistant to regular chemotherapy radiotherapy. The AT-rich interactive domain containing protein 1A (ARID1A) gene, a crucial chromatin remodeling mutates frequently in broad spectrum of including pancreatic cancer. Recent evidence suggests that ARID1A acts as tumor suppressor plays an important role DNA damage repair (DDR). However, effect on radiosensitivity remains unclear. Herein, we investigated involvement depletion...
BackgroundThree recent genome-wide association studies (GWASs) have reported that three SNPs (rs4072037, rs13361707 and rs2274223) located on genes related to host inflammatory response are significantly associated with susceptibility gastric cancer (GC) in Chinese populations. Helicobacter pylori infection is also an important risk factor for GC through causing the mucosa. However, no study has established whether there potential gene-environment interactions between these genetic variants...
Immune-checkpoint signaling plays an important role in immunosuppression of tumors. We aimed to investigate the association soluble programmed death-ligand 1 (sPD-L1) level plasma with overall survival (OS) locally advanced or inoperable nonsmall-cell lung cancer (NSCLC) patients treated thoracic radiotherapy (TRT). used ELISA evaluate sPD-L1 levels at diagnosis and during TRT 126 clinically NSCLC patients. OS rates were followed up recorded. SPSS software GraphPad Prism 5 for statistics. In...
The overexpression or amplification of HER2 has been observed in a significant proportion both gastric cancer (GC) and breast (BC) cases. Pyrotinib is an irreversible dual (EGFR/HER2) tyrosine kinase inhibitor (TKI), newly evaluated for the treatment HER2‑overexpressing types. As radiotherapy (RT) serves crucial role controlling local recurrence GC BC, present study investigated impact pyrotinib on irradiation response. current results demonstrated that enhanced radiosensitivity BC cells...
The recovery of precious metals from secondary resources is significant economically and environmentally. However, their separation still challenging because they often occur in complex metal ion mixtures. poor selectivity adsorbents for gold complicated solutions prevents further application adsorption technology. In this study, a Zr-based MOF adsorbent, MIL-161, was synthesized using s-tetrazine dicarboxylic acid (H2STz) as an organic ligand. MIL-161 demonstrated high capacity up to 446.49...
Integrins play an important role in multiple stages of tumor progression and metastasis. Previous studies have shown synergistic effects combined αvβ6-integrin αvβ8-integrin inhibitors with immunotherapy. However, the αvβ3-integrin inhibitor immunity is still unclear. In this study, we aimed to elucidate impact on PD-L1 expression sensitivity immune checkpoint blockade melanoma. We investigated cilengitide, inhibitor, cell viability apoptosis melanoma lines. And explored how cilengitide...
Heavy metals released in the environment pose a huge threat to soil and water quality, food safety public health. Additionally, humans other mammals may also be directly exposed heavy or through chain, which seriously threatens health of animals humans. Chromium, especially hexavalent chromium [Cr (VI)], as common metal, has been shown cause serious environmental pollution well intestinal damage. Thus, increasing research is devoted finding drugs mitigate negative effects exposure. Seaweed...
There is currently no consensus on the relationship between human papillomavirus (HPV) infection and pathogenic process of esophageal squamous cell carcinoma (ESCC). Therefore, a retrospective study was performed to explore association HPV ESCC, where 225 patients with diagnosed ESCC 224 matched controls were enrolled in stratified according smoking alcohol consumption. Enzyme‐linked immunosorbent assay used determine seropositivity by detection either IgG or IgM anti‐HPV antibodies. In...