A5101494463- Dementia and Cognitive Impairment Research
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Frailty in Older Adults
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health disparities and outcomes
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Nutrition and Health in Aging
- Obesity and Health Practices
- Cardiac Health and Mental Health
- Physical Activity and Health
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Health Promotion and Cardiovascular Prevention
- Acute Myocardial Infarction Research
- Global Public Health Policies and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Sodium Intake and Health
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Alzheimer's disease research and treatments
Finnish Institute for Health and Welfare
2014-2024
Seinäjoki University of Applied Sciences
2007-2024
University of Helsinki
2013-2023
King Abdulaziz University
2014-2023
Escuela Nacional de Sanidad
2019-2023
Instituto de Salud Carlos III
2023
Universität für Weiterbildung Krems
2011-2021
Dasman Diabetes Institute
2016-2019
University of Eastern Finland
1983-2017
Finland University
2017
BackgroundObservational epidemiological studies have shown a positive association between hypertension and risk of incident dementia; however, the effects antihypertensive therapy on cognitive function in controlled trials been conflicting, meta-analyses not provided clear evidence whether treatment reduces dementia incidence. The Hypertension Very Elderly trial (HYVET) was designed to assess risks benefits elderly patients included an assessment function.MethodsPatients with (systolic...
To evaluate the impact of midlife elevated serum cholesterol levels and blood pressure on subsequent development mild cognitive impairment (MCI) to investigate prevalence MCI in elderly Finnish population, applying criteria devised by Mayo Clinic Alzheimer's Disease Research Center.MCI has been considered as a predictor AD. Vascular risk factors may be important However, role vascular still remain virtually unknown.Subjects were derived from random, population-based samples previously...
The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also elevated serum total cholesterol low-density lipoprotein levels. However, interrelationships between apoE genotype, plasma levels AD risk have been studied very little. We examined possible role in pathogenesis a population-based sample 444 men, aged 70-89 years, who were survivors Finnish cohorts Seven Countries Study. Previous high level (mean > or = 6.5 mmol/l) was significant...
Background: Presence of the apolipoprotein E (apoE) ε4 allele, which is involved in cholesterol metabolism, most important genetic risk factor for Alzheimer disease. Elevated midlife values total level and blood pressure have been implicated recently as factors Objective: To study relative importance putative relationship among apoE level, late-life Design: Prospective population-based study. Setting: Kuopio Joensuu, eastern Finland. Participants: Participants were derived from random...
We examined the relationship among low, moderate, and high levels of hopelessness, all-cause cause-specific mortality, incidence myocardial infarction (MI) cancer in a population-based sample middle-aged men. Participants were 2428 men, ages 42 to 60, from Kuopio Ischemic Heart Disease study, an ongoing longitudinal study unestablished psychosocial risk factors for ischemic heart disease other outcomes. In 6 years follow-up, 174 deaths (87 cardiovascular 87 noncardiovascular, including 40 29...
Much remains to be understood about how low socioeconomic status (SES) increases cardiovascular disease and mortality risk. Data from the Kuopio Ischemic Heart Disease Risk Factor Study (1984–1993) were used estimate associations between acute myocardial infarction income, all-cause mortality, in a population-based sample of 2, 272 Finnish men, with adjustment for 23 biologic, behavioral, psychologic, social risk factors. Compared highest income quintile, those bottom quintile had...
Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland.Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-intervention studies. Inclusion criteria CAIDE Dementia Risk Score ≥6 performance the mean level or slightly lower than expected for age (but not substantial impairment) assessed with Consortium Establish Registry Alzheimer's...
The prevalence and socioeconomic burden of type 2 diabetes (T2DM) associated co-morbidities are rising worldwide.This guideline provides evidence-based recommendations for preventing T2DM.A European multidisciplinary consortium systematically reviewed the evidence on effectiveness screening interventions T2DM prevention using SIGN criteria.Obesity sedentary lifestyle main modifiable risk factors. Age ethnicity non-modifiable Case-finding should follow a step-wise procedure questionnaires...
Background and Purpose —The World Health Organization data bank is an invaluable source of information for international comparison mortality trends. We present rates trends in from stroke up to 1994, with a particular emphasis on the last 10-year period. Data are presented men women 51 industrialized developing countries different parts world. Methods —We included all deaths cerebrovascular disease population aged 35 84 years which death certificates were estimated be available at least 80%...
OBJECTIVE—To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. RESEARCH DESIGN AND METHODS—We prospectively followed 51,552 Finnish men and women 25–74 years of age without history disease baseline. History other study parameters were determined using standardized measurements. Ascertainment the status was based on nationwide Social Insurance Institution's drug register data. Hazard ratios incident associated with estimated. RESULTS—During mean follow-up...
Caffeine stimulates central nervous system on a short term. However, the long-term impact of caffeine cognition remains unclear. We aimed to study association between coffee and/or tea consumption at midlife and dementia/Alzheimer's disease (A
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The risk of dementia and Alzheimer's disease (AD) probably results from an interaction between genetic environmental factors. aim this study was to investigate the effects putative interactions apoE epsilon4 allele lifestyle related factors for AD. Participants Cardiovascular Risk Factors, Aging, Dementia (CAIDE) were derived random, population-based samples previously studied in 1972, 1977, 1982 or 1987. After average follow-up 21 years, 1449 individuals (72.5%) aged 65-79 years re-examined...
Abstract Introduction The 2‐year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced Methods FINGER recruited 1260 people from the general population (60–77 years, at risk for dementia). Participants were randomized 1:1 (diet,...
To investigate the association of midlife dietary fat intake to cognitive performance, and occurrence clinical mild impairment (MCI) later in life a non-demented population.A longitudinal population-based study.Populations Kuopio Joensuu, Eastern Finland.Participants CAIDE study were derived from random, samples studied at (1972, 1977, 1982 or 1987). After an average follow-up 21 years, total 1449 (72%) individuals aged 65-80 years participated re-examination 1998. Altogether 82 (5.7%)...
The role of the apolipoprotein E (APOE) ε4 allele as an effect modifier in lifestyle interventions to prevent cognitive impairment is still unclear.To examine whether APOE modifies previously reported significant benefits a multidomain intervention (prespecified subgroup analysis).The Finnish Geriatric Intervention Study Prevent Cognitive Impairment and Disability (FINGER) was randomized clinical trial 6 centers across Finland (screening randomization performed from September 7, 2009,...
OBJECTIVES: This study assessed the consistency and magnitude of association between educational level relative body weight in populations with widely different prevalences over-weight investigated possible changes over 10 years. METHODS: Differences age-adjusted mean mass index (BMI) highest lowest tertiles years schooling were calculated for 26 initial final surveys World Health Organization (WHO) MONICA (Monitoring Trends Determinants Cardiovascular Disease) Project. The data are derived...
Fish contains high concentrations of omega-3 polyunsaturated fatty acids. Several studies have reported depletions fats among depressed patients, and a cross-national comparison has revealed significant inverse correlation between annual prevalence major depression fish consumption. In sample 3,204 Finnish adults, depressive symptoms were estimated with the Beck Depression Inventory. A frequency question was used to measure Multiple logistic regression analysis conducted assess association...
The recent introduction of sensitive markers myocardial injury is likely to affect the epidemiology coronary heart disease (CHD). American Heart Association together with other societies and research agencies have recently published a new definition on acute CHD improve consistency in epidemiological clinical studies (referred here as '2003 definition').In this study we compare data events Finnish National Hospital Discharge Register (HDR) Causes Death (CDR) population-based infarction (MI)...
To evaluate the relation between midlife alcohol consumption and mild cognitive impairment dementia in old age, possible modification of this by apolipoprotein E.Prospective, population based study.Populations Kuopio Joensuu, eastern Finland.Of 1464 men women aged 65-79 years randomly selected from samples studied 1972 or 1977, 1018 (70%) were re-examined 1998 (after an average follow up 23 years).Mild age.Participants who drank no at those frequently both twice as likely to have age...
AimsTo investigate separately for men and women whether moderate or high leisure time physical activity, occupational commuting activity are associated with a reduced cardiovascular disease (CVD) all-cause mortality, independent of CVD risk factors other forms activity.
<i>Background:</i> Lifestyle and vascular factors have been linked to dementia Alzheimer’s disease (AD), but the role of dietary fats in development is less clear. <i>Methods:</i> Participants were derived from random, population-based samples initially studied midlife (1972, 1977, 1982, or 1987). Fat intake spreads milk products was assessed using a structured questionnaire an interview. After average follow-up 21 years, total 1,449 (73%) individuals aged 65–80 years...