A5073351502- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Nutrition, Genetics, and Disease
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Dietary Effects on Health
- Helicobacter pylori-related gastroenterology studies
- Biochemical Analysis and Sensing Techniques
- Gastroesophageal reflux and treatments
- Lipid metabolism and disorders
- Obesity, Physical Activity, Diet
- Peroxisome Proliferator-Activated Receptors
German Institute of Human Nutrition
2016-2025
Charité - Universitätsmedizin Berlin
2016-2025
Helmholtz Zentrum München
2019-2025
Heinrich Heine University Düsseldorf
2016-2025
Deutsches Diabetes-Zentrum e.V.
2016-2025
German Center for Diabetes Research
2016-2025
European Organization for Nuclear Research
2005-2025
Humboldt-Universität zu Berlin
2012-2024
Freie Universität Berlin
2004-2024
The University of Texas Health Science Center at San Antonio
2021-2024
A subclinical inflammatory reaction has been shown to precede the onset of type 2 (non-insulin-dependent) diabetes. We therefore examined prospectively effects central cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) on development designed a nested case-control study within prospective population-based European Prospective Investigation into Cancer Nutrition (EPIC)-Potsdam including 27,548 individuals. Case subjects were defined be those who free diabetes at baseline...
The kappa opioid agonists are analgesics that seem to be free of undesired morphine-like effects. Their dysphoric actions observed with the agonist cyclazocine thought mediated by an action at sigma-phencyclidine receptors. benzomorphan MR 2033 is inactive In male subjects, opiate-active (-)-isomer, but not (+)-isomer, elicited dose-dependent and psychotomimetic effects were antagonized naloxone. Thus, opiate receptors mediate view euphorigenic properties mu agonists, our results imply...
Studies of weight-control diets that are high in protein or low glycemic index have reached varied conclusions, probably owing to the fact studies had insufficient power.We enrolled overweight adults from eight European countries who lost at least 8% their initial body weight with a 3.3-MJ (800-kcal) low-calorie diet. Participants were randomly assigned, two-by-two factorial design, one five ad libitum prevent regain over 26-week period: low-protein and low-glycemic-index diet,...
There is increasing evidence of genetic factors leading to obesity, but the exact genes involved have not been defined. Peroxisome-proliferator–activated receptor γ2 (PPARγ2) a transcription factor that has key role in adipocyte differentiation, and therefore mutations gene for this might predispose people obesity.
The prevalence and socioeconomic burden of type 2 diabetes (T2DM) associated co-morbidities are rising worldwide.This guideline provides evidence-based recommendations for preventing T2DM.A European multidisciplinary consortium systematically reviewed the evidence on effectiveness screening interventions T2DM prevention using SIGN criteria.Obesity sedentary lifestyle main modifiable risk factors. Age ethnicity non-modifiable Case-finding should follow a step-wise procedure questionnaires...
Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. To elucidate relationship between adiponectin, gene expression in adipose tissue, markers inflammation, we obtained blood samples, anthropometric measures, subcutaneous tissue samples from 65 postmenopausal healthy women. Adiponectin adipose-tissue were significantly lower obese subjects inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein...
We aimed to develop a precise risk score for the screening of large populations individuals at high developing type 2 diabetes based on noninvasive measurements major factors in German study populations.A prospective cohort (European Prospective Investigation into Cancer and Nutrition [EPIC]-Potsdam study) 9,729 men 15,438 women aged 35-65 years was used derive predicting incident diabetes. Multivariate Cox regression model coefficients were weigh each variable calculation score. Data from...
Measurement of IGF-I is a cornerstone in diagnosis and monitoring GH-related diseases, but considerable discrepancies exist between analytical methods. A recent consensus conference defined criteria for validation assays establishment normative data.Our objectives were development novel automated immunoassay (iSYS; Immunodiagnostic Systems) according to international guidelines method-specific age- sex-adjusted reference intervals analysis their robustness.We conducted multicenter study with...
OBJECTIVE To evaluate whether the sodium–glucose cotransporter 2 inhibitor empagliflozin (EMPA) reduces liver fat content (LFC) in recent-onset and metabolically well-controlled type diabetes (T2D). RESEARCH DESIGN AND METHODS Patients with T2D (n = 84) (HbA1c 6.6 ± 0.5% [49 10 mmol/mol], known disease duration 39 27 months) were randomly assigned to 24 weeks of treatment 25 mg daily EMPA or placebo. The primary end point was difference change LFC as measured magnetic resonance methods from...
Abstract D -Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism activates AMP-activated protein kinase (AMPK/AAK-2) increases mitochondrial biogenesis. Consistent with concept mitohormesis, GlcN promotes increased formation reactive oxygen...
There is a growing interest in the role of inflammageing for chronic disease development. Cytokines are potent soluble immune mediators that can be used as target biomarkers inflammageing; however, their measurement human samples has been challenging. This study aimed to assess reliability pro- and anti-inflammatory cytokine panel sample healthy people measured with novel electrochemiluminescent multiplex immunoassay platform (Meso Scale Discovery, MSD), characterize associations metabolic...
OBJECTIVE—Cereal fiber intake is linked to reduced risk of type 2 diabetes in epidemiological observations. The pathogenic background this phenomenon unknown. Based on recent findings, we hypothesized that purified insoluble oat may improve whole-body insulin sensitivity. RESEARCH DESIGN AND METHODS—A randomized, controlled, single-blind, cross-over study was performed, and 17 overweight or obese subjects with normal glucose metabolism were analyzed. After consumption nine...