A5081900195- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Nutrition, Genetics, and Disease
- Health and Lifestyle Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Pharmacology and Obesity Treatment
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Behavioral Health and Interventions
- Physical Activity and Health
- Dietary Effects on Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Bariatric Surgery and Outcomes
- Dermatology and Skin Diseases
- Nutrition and Health in Aging
- Consumer Attitudes and Food Labeling
- Food Allergy and Anaphylaxis Research
- Agriculture Sustainability and Environmental Impact
Medical University of Sofia
2014-2024
European CanCer Organisation
2023
University of Design Schwäbisch Gmünd
2022
University of Education
2022
European Association for the Study of Obesity
2020
National Transport Hospital "Tzar Boris III"
2009-2015
Inserm
2010-2011
University of Copenhagen
2011
German Institute of Human Nutrition
2011
Maastricht University Medical Centre
2011
Studies of weight-control diets that are high in protein or low glycemic index have reached varied conclusions, probably owing to the fact studies had insufficient power.We enrolled overweight adults from eight European countries who lost at least 8% their initial body weight with a 3.3-MJ (800-kcal) low-calorie diet. Participants were randomly assigned, two-by-two factorial design, one five ad libitum prevent regain over 26-week period: low-protein and low-glycemic-index diet,...
Diogenes is a Pan-European, randomized, controlled dietary intervention study investigating the effects of protein and glycaemic index on weight (re)gain, metabolic cardiovascular risk factors in obese overweight families eight European centres. The article methodological character, presentation 'results' will be limited to baseline characteristics populations included. A total 891 with at least one overweight/obese parent underwent screening. parents started an initial 8-week low-calorie...
We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes body on cardiovascular risk factors within Diet, Obesity, Genes study (DiOGenes).DiOGenes is a pan-European controlled dietary intervention 932 overweight adults who first lost an 8-week low-calorie diet were then randomized 1 5 ad libitum for 26 weeks. The high low 4 combinations control. Weight (-11.23 kg; 95% confidence interval, -11.54 -10.92;...
Aims The PREVIEW lifestyle intervention study ( ClinicalTrials.gov Identifier: NCT01777893) is, to date, the largest, multinational concerning prevention of type‐2 diabetes. We hypothesized that initial, fixed low‐energy diet (LED) would induce different metabolic outcomes in men vs women. Materials and methods All participants followed a LED (3.4 MJ/810 kcal/daily) for 8 weeks (Cambridge Weight Plan). Participants were recruited from sites Europe, Australia New Zealand. Those eligible...
Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find most effective lifestyle (diet and physical activity) for prevention T2D, in overweight obese participants with increased risk T2D. study a three-year multi-centre, 2 × factorial, randomised controlled trial. impact high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet combination or high-intensity activity on incidence T2D related clinical...
Abstract Aim To compare the impact of two long‐term weight‐maintenance diets, a high protein (HP) and low glycaemic index (GI) diet versus moderate (MP) GI diet, combined with either intensity (HI) or physical activity (PA), on incidence type 2 diabetes (T2D) after rapid weight loss. Materials Methods A 3‐year multicentre randomized trial in eight countries using x diet‐by‐PA factorial design was conducted. Eight‐week reduction followed by phase. In total, 2326 adults (age 25‐70 years, body...
OBJECTIVE: To investigate the effect of protein and glycemic index (GI) on body composition among European children in randomized, 6-month dietary intervention DiOGenes (diet, obesity, genes) family-based study. PATIENTS AND METHODS: In study, 827 (381 boys 446 girls), aged 5 to 18 years, completed baseline examinations. Families with parents who lost ≥8% their weight during an 8-week run-in low-calorie diet period were randomly assigned 1 ad libitum diets: low (LP)/low (LGI); LP/high GI...
The aim of this study was to describe the development and implementation a multifaceted, low-fat, weight-loss strategy for Pan-European randomized controlled dietary intervention study, Diogenes. There were 891 families with at least one overweight/obese parent who underwent screening. Eligible, adults followed an 8-week phase fixed low-energy diet (800 kcal). On attaining weight loss > or = 8%, 6- 12-month low-fat (25-30%E) either based on national guidelines four interventions: low protein...
Summary There is growing evidence that the glycaemic index (GI) of diet important with respect to body weight and metabolic disease risk. However, research limited by paucity GI values for commonly consumed carbohydrate‐rich foods in European countries. A new methodology has been developed consistent assignment across five databases used Diogenes intervention study. were assigned according decreasing levels confidence (1) Measured specific foods; (2) Published from published sources; (3)...
Abstract Background Physical activity, sedentary time and sleep have been shown to be associated with cardio-metabolic health. However, these associations are typically studied in isolation or without accounting for the effect of all movement behaviours constrained nature data that comprise a finite whole such as 24 h day. The aim this study was examine between composition daily (including sleep, (ST), light intensity physical activity (LIPA) moderate-to-vigorous (MVPA)) health,...
Background Weight regain after weight loss is common. In the Diogenes dietary intervention study, high protein and low glycemic index (GI) diet improved maintenance. Objective To identify blood predictors for change following within study. Design Blood samples were collected at baseline 8-week caloric diet-induced from 48 women who continued to lose regained during subsequent 6-month period with 4 diets varying in GI levels. Thirty-one proteins 3 steroid hormones measured. Results...
Fatty acid composition of adipose tissue changes with weight loss. Palmitoleic as a possible marker endogenous lipogenesis or its functions lipokine are under debate. Objective was to assess the predictive role triglycerides fatty acids in maintenance participants DIOGENES dietary intervention study. After an 8-week low calorie diet (LCD) subjects > 8 % loss were randomized 5 ad libitum diets for 6 months: protein (P)/low glycemic index (GI) (LP/LGI), P/high GI (LP/HGI), high P/low...
OBJECTIVE The aim of the present cross-sectional study was to examine association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25–70 years old, 67% female) from eight countries, a BMI >25 kg ⋅ m−2 impaired fasting glucose (5.6–6.9 mmol L−1) or tolerance (7.8–11.0 L−1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels ST. RESULTS Multiple linear...
An increase in dietary protein intake has been shown to improve weight loss maintenance the DIOGenes trial. Here, we analysed whether source of proteins influenced changes body weight, composition, and cardiometabolic risk factors during period while following an energy-restricted diet. 489 overweight or obese participants trial from eight European countries were included. They successfully lost >8% subsequently completed a six month period, which they consumed ad libitum diet varying...