A5063705490- Diet and metabolism studies
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Cardiovascular and exercise physiology
- Sports Performance and Training
- Exercise and Physiological Responses
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Consumer Attitudes and Food Labeling
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Biochemical Analysis and Sensing Techniques
- Metabolism, Diabetes, and Cancer
- Physical Activity and Health
- Body Composition Measurement Techniques
- Fatty Acid Research and Health
- Thermoregulation and physiological responses
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacology and Obesity Treatment
- Eating Disorders and Behaviors
- Dietary Effects on Health
Maastricht University
2013-2023
Maastricht University Medical Centre
2013-2022
University of Copenhagen
2002-2019
University Medical Center
2017-2019
University Hospital and Clinics
2018
Cambridge University Press
2010-2017
New York University Press
2010-2017
University of Reading
2009-2016
DSM (Netherlands)
2009-2016
Netherlands Metabolomics Centre
2016
Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the contribution to efficient weight loss in response dietary intervention remains unknown. We perform a GWAS two large low-caloric diet cohorts obese participants. Two loci close NKX6.3/MIR486 and RBSG4 are identified Canadian discovery cohort (n = 1166) replicated DiOGenes 789). Modulation HGTX (NKX6.3 ortholog) levels Drosophila...
Studies of weight-control diets that are high in protein or low glycemic index have reached varied conclusions, probably owing to the fact studies had insufficient power.We enrolled overweight adults from eight European countries who lost at least 8% their initial body weight with a 3.3-MJ (800-kcal) low-calorie diet. Participants were randomly assigned, two-by-two factorial design, one five ad libitum prevent regain over 26-week period: low-protein and low-glycemic-index diet,...
1. Contemporary stable isotope methodology was applied in combination with muscle biopsy sampling to accurately quantify substrate utilisation and study the regulation of fuel selection during exercise. 2. Eight cyclists were studied at rest three consecutive 30 min stages exercise intensities 40, 55 75 % maximal workload (W(max)). A continuous infusion [U-(13)C]palmitate [6,6-(2)H(2)]glucose administered determine plasma free fatty acid (FFA) oxidation estimate glucose oxidation,...
The extensive use of performance tests in diet intervention studies mirrors the importance such a measurement. Although many different endurance have been used past, majority these protocols has never validated. In this study reproducibility three was evaluated. Thirty well-trained subjects were matched on age, weight, and Wmax divided into subgroups. Each group performed one exercise protocols: protocol (A) consisted cycling at 75% until exhaustion. (B) received preload 45 min 70% then as...
Mechanisms for liraglutide-induced weight loss are poorly understood. We investigated the effects of liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese non-diabetic individuals. Participants (N=49, 18–75 years, body mass index: 30–40 kg m−2) were randomized to two three treatments: 1.8 mg, 3.0 or placebo a double-blind, incomplete crossover trial. After 5 weeks, 24-h expenditure (EE) substrate oxidation measured respiratory chamber. Gastric emptying...
Background: Optimal nutritional choices are linked with better health, but many current interventions to improve diet have limited effect. We tested the hypothesis that providing personalized nutrition (PN) advice based on information individual and lifestyle, phenotype and/or genotype would promote larger, more appropriate, sustained changes in dietary behaviour. Methods: Adults from seven European countries were recruited an internet-delivered intervention (Food4Me) randomized to: (i)...
Comprehensive, high throughput analysis of the plasma proteome has potential to enable holistic health state an individual. Based on our own experience and evaluation recent large-scale mass spectrometry (MS) based proteomic studies, we identified two outstanding challenges: slow delicate nano-flow liquid chromatography (LC) irreproducibility identification data-dependent acquisition (DDA). We determined optimal solution reducing these limitations with robust capillary-flow data-independent...
Physical activity patterns and their relation with coronary heart disease risk factors are described for a representative sample of 863 Dutch men, 65–84 years old, who participated in the 1985 survey Zutphen cohort Seven Countries Study. Cross-sectional results revealed median total reported physical about 1 hour 20 minutes per day; only 5.8% no activity. The percentage participation weekly time spent decreased as age increased; decrease was less pronounced walking, bicycling, gardening,...
We determined whether increased glycolytic flux from hyperglycemia and hyperinsulinemia directly reduces fatty acid oxidation during exercise. Fatty rates were measured constant-rate intravenous infusion of trace amounts a long-chain ([1-13C]palmitate; Pal) vs. medium-chain ([1-13C]octanoate; Oct). Six endurance-trained men cycled for 40 min at 50% maximal O2 uptake 1) after an overnight fast (“fasting”) 2) ingestion 1.4 g/kg glucose 60 again 10 before exercise (Glc). Glc caused...