A5013490912- Diet and metabolism studies
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Coffee research and impacts
- Mitochondrial Function and Pathology
- Molecular Biology Techniques and Applications
- Probiotics and Fermented Foods
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism, Diabetes, and Cancer
- Plant Virus Research Studies
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Nutrition, Genetics, and Disease
- HIV Research and Treatment
- Cocoa and Sweet Potato Agronomy
- Transgenic Plants and Applications
- Cancer Treatment and Pharmacology
- Pancreatic function and diabetes
- Gene expression and cancer classification
- Genomics and Rare Diseases
Nestlé (Switzerland)
2015-2024
École Polytechnique Fédérale de Lausanne
2014-2023
Nestlé (Brazil)
2019-2022
Nestlé (France)
2021-2022
École Polytechnique
2019
TU Dresden
2019
University of Geneva
2000-2014
SIB Swiss Institute of Bioinformatics
2005-2011
Hôpital Cochin
2011
Université Paris Cité
2011
Understanding why some people establish and maintain effective control of HIV-1 others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using whole-genome association strategy, we identified polymorphisms that explain nearly 15% variation among individuals viral load during asymptomatic set-point period infection. One these found within an endogenous retroviral element associated with major histocompatibility allele human leukocyte antigen ( HLA )– B*5701 , whereas...
Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the contribution to efficient weight loss in response dietary intervention remains unknown. We perform a GWAS two large low-caloric diet cohorts obese participants. Two loci close NKX6.3/MIR486 and RBSG4 are identified Canadian discovery cohort (n = 1166) replicated DiOGenes 789). Modulation HGTX (NKX6.3 ortholog) levels Drosophila...
A gene, encoding a liver-enriched transcriptional activator protein (LAP) has been isolated. LAP is 32-kD that stimulates the transcription of chimeric genes containing albumin D-promoter elements both in vivo and vitro. shares extensive sequence homology (71%) its DNA-binding leucine zipper domains with C/EBP. As consequence, these two proteins show an indistinguishable specificity readily heterodimerize. In addition, genes, lap cebp, are devoid intervening sequences. Although correctly...
Antibiotic resistance is rising in important bacterial pathogens. Phage therapy (PT), the use of viruses infecting pathogen a species-specific way, potential alternative.T4-like coliphages or commercial Russian coliphage product placebo was orally given over 4 days to Bangladeshi children hospitalized with acute diarrhea. Safety oral phage assessed clinically and by functional tests; Escherichia coli titers enteropathogens were determined stool quantitative diarrhea parameters (stool output,...
To extend the understanding of host genetic determinants HIV-1 control, we performed a genome-wide association study in cohort 2,554 infected Caucasian subjects. The was powered to detect common variants explaining down 1.3% variability viral load at set point. We provide overwhelming confirmation three associations previously reported and show further independent effects both rare Major Histocompatibility Complex region (MHC). also examined polymorphisms previous candidate gene studies fail...
The CCAAT/enhancer-binding protein (C/EBP) alpha is a leucine zipper that preferentially expressed in certain cell types, such as adipocytes and hepatocytes. Here we show C/EBP mRNA translated into two major proteins, C/EBP-42 C/EBP-30, differ their content of N-terminal amino acid sequences. These results are best explained by ribosome-scanning mechanism which fraction ribosomes ignore the first AUGs initiate translation at an AUG located 351 nt downstream one. Because product initiated...
Glomalean fungi induce and colonize symbiotic tissue called arbuscular mycorrhiza on the roots of most land plants. Other also plants but cause disease not symbiosis. Whole-transcriptome analysis using a custom-designed Affymetrix Gene-Chip confirmation with real-time RT-PCR revealed 224 genes affected during mycorrhizal We compared these transcription profiles those from rice that were colonized by pathogens ( Magnaporthe grisea Fusarium moniliforme ). Over 40% showed differential...
Aging | doi:10.18632/aging.100861. Steve Horvath, Chiara Pirazzini, Maria Giulia Bacalini, Davide Gentilini, Anna Di Blasio, Massimo Delledonne, Daniela Mari, Beatrice Arosio, Monti, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Cristina Giuliani, Elena Marasco, Sebastiano Collino, Patrick Descombes, Paolo Garagnani, Claudio Franceschi
Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-nucleus communication and calcium signals in the cell nucleus. Here we show hippocampal neurons nuclear is one of most potent neuronal gene expression. The induction or repression 185 activity-regulated genes dependent upon signaling. calcium-regulated pool contains genomic program mediates synaptic activity-induced, acquired neuroprotection. core set neuroprotective consists 9 principal components,...
Abstract Background RT-qPCR is a sensitive and increasingly used method for gene expression quantification. To normalize measurements between samples, most laboratories use endogenous reference genes as internal controls. There increasing evidence, however, that the of commonly can vary significantly in certain contexts. Results Using Genevestigator database normalized well-annotated microarray experiments, we describe stability characteristics transciptomes several organisms. The results...
Gut microbes influence their hosts in many ways, particular by modulating the impact of diet. These effects have been studied most extensively humans and mice. In this work, we used whole genome metagenomics to investigate relationship between gut metagenomes dogs, humans, mice, pigs. We present a dog microbiome gene catalog containing 1,247,405 genes (based on 129 total 1.9 terabasepairs sequencing data). Based taxonomic abundance profiling, show that is closer human than either pigs or To...
The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related wasting weakness termed sarcopenia, which directly impacts physical autonomy survival. Here, we compare genome-wide transcriptional changes sarcopenia versus age-matched controls biopsies from 119 older men Singapore, Hertfordshire UK Jamaica. Individuals with reproducibly demonstrate a prominent signature mitochondrial bioenergetic...
Diurnal oscillations of gene expression are a hallmark rhythmic physiology across most living organisms. Such controlled by the interplay between circadian clock and feeding rhythms. Although mRNA accumulation has been extensively studied, comparatively less is known about their transcription translation. Here, we quantified simultaneously temporal transcription, accumulation, translation mouse liver mRNAs under physiological light-dark conditions ad libitum or night-restricted in WT brain...
Human milk is the sole and recommended nutrition for newborn infant contains one of largest constituents diverse oligosaccharides, dubbed human oligosaccharides (HMOs). Preclinical clinical association studies indicate that HMOs have multiple physiological functions largely mediated through establishment gut microbiome. Until recently, were not available to investigate their role in randomized controlled intervention trials. To our knowledge, this first report on effects 2 establishing...
Abstract Coffea arabica , an allotetraploid hybrid of eugenioides and canephora is the source approximately 60% coffee products worldwide, its cultivated accessions have undergone several population bottlenecks. We present chromosome-level assemblies a di-haploid C. accession modern representatives diploid progenitors, . The three species exhibit largely conserved genome structures between parents descendant subgenomes, with no obvious global subgenome dominance. find evidence for founding...