A5007024246- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Extracellular vesicles in disease
- Lipid metabolism and disorders
- Muscle Physiology and Disorders
- Cellular Mechanics and Interactions
Nestlé (Switzerland)
2018-2022
École Polytechnique Fédérale de Lausanne
2016-2022
Cornell University
2022
Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and metabolism declines during aging. Through yeast one-hybrid transcription factor binding screen, we identified the TEA domain 1 (Tead1) as novel regulator of Apln promoter. Single-cell analysis regenerating revealed apelin receptor (Aplnr) enriched in endothelial cells, whereas Tead1 myogenic cells. Knock-down stimulates secretion from cells vitro myofiber-specific overexpression suppresses vivo. via knock-down cell...