A5049484291- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Frailty in Older Adults
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Diet and metabolism studies
- Aging, Elder Care, and Social Issues
- Cholinesterase and Neurodegenerative Diseases
- Geriatric Care and Nursing Homes
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Body Composition Measurement Techniques
- Health, Medicine and Society
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Chronic Disease Management Strategies
- Pharmaceutical Practices and Patient Outcomes
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- GDF15 and Related Biomarkers
- Ginkgo biloba and Cashew Applications
- Fatty Acid Research and Health
- Blood Pressure and Hypertension Studies
Université de Toulouse
2016-2025
Inserm
2016-2025
Médipole Garonne
2015-2025
Centre Hospitalier Universitaire de Toulouse
2016-2025
Université Toulouse III - Paul Sabatier
2015-2024
Institut de Mathématiques de Toulouse
2015-2024
University of New Mexico
1997-2023
Amsterdam Neuroscience
2023
Vrije Universiteit Amsterdam
2023
Amsterdam University Medical Centers
2023
The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer's disease. Lecanemab, a humanized IgG1 monoclonal antibody that binds with high affinity to Aβ protofibrils, is being tested persons early
Background. The Mini-Nutritional Assessment (MNA) is a validated assessment instrument for nutritional problems, but its length limits usefulness screening. We sought to develop screening version of this instrument, the MNA-SF, that retains good diagnostic accuracy. Methods. reanalyzed data from France were used original MNA and combined these with collected in Spain New Mexico. Of 881 subjects complete data, 151 France, 400 Spain, 330 Independent ratings clinical status available 142 French...
Alzheimer's disease is characterized by amyloid-beta plaques, neurofibrillary tangles, gliosis, and neuronal loss. Solanezumab, a humanized monoclonal antibody, preferentially binds soluble forms of amyloid in preclinical studies promoted its clearance from the brain.In two phase 3, double-blind trials (EXPEDITION 1 EXPEDITION 2), we randomly assigned 1012 1040 patients, respectively, with mild-to-moderate to receive placebo or solanezumab (administered intravenously at dose 400 mg) every 4...
Alzheimer's disease is characterized by the presence of cortical amyloid-beta (Aβ) protein plaques, which result from sequential action β-secretase and γ-secretase on amyloid precursor protein. Semagacestat a small-molecule inhibitor that was developed as potential treatment for disease.
OBJECTIVES: To provide pooled data on the prevalence of malnutrition in elderly people as evaluated using Mini Nutritional Assessment (MNA). DESIGN: Retrospective analysis previously published datasets. SETTING: Hospital, rehabilitation, nursing home, community. PARTICIPANTS: Four thousand five hundred seven (75.2% female) with a mean age 82.3. MEASUREMENTS: The combined database and four settings was examined. RESULTS: Twenty‐four sets information full MNA classification from researchers 12...
Alzheimer's disease is characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The humanized monoclonal antibody solanezumab was designed to increase the clearance from brain of soluble Aβ, peptides that may lead toxic effects in synapses precede deposition fibrillary amyloid.
to identify the characteristics of elderly persons who develop a fear falling after experiencing fall and investigate association this with changes in health status over time. prospective study falls 2-year period (1991–92). Falls were ascertained using bimonthly postcards plus telephone interview standardized (World Health Organisation) questionnaire for circumstances, consequences each reported fall. Each participant underwent physical exam subjective assessment year from 1990 1993....
Alzheimer's disease is a progressive, irreversible, and fatal for which accumulation of amyloid beta thought to play key role in pathogenesis. Aducanumab human monoclonal antibody directed against aggregated soluble insoluble forms beta.We evaluated the efficacy safety aducanumab early disease.EMERGE ENGAGE were two randomized, double-blind, placebo-controlled, global, phase 3 studies patients with disease.These involved 348 sites 20 countries.Participants included 1638 (EMERGE) 1647...
The human ageing process is universal, ubiquitous and inevitable. Every physiological function being continuously diminished. There a range between two distinct phenotypes of ageing, shaped by patterns living - experiences behaviours, in particular the presence or absence physical activity (PA) structured exercise (i.e., sedentary lifestyle). Ageing lifestyle are associated with declines muscle cardiorespiratory fitness, resulting an impaired capacity to perform daily activities maintain...
The task force of the International Conference Frailty and Sarcopenia Research (ICFSR) developed these clinical practice guidelines to overview current evidence-base provide recommendations for identification management frailty in older adults.